DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut1 and MPH3

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_012694.1	Gene:	MPH3 / 853625	SGDID:	S000003921	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	543	Identity:	119/543 - (21%)
Similarity:	203/543 - (37%)	Gaps:	92/543 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NRV--ELLSAQTDPSQKPRWGNLLLLVALATTFGGA------VST-----GYCIGVINAPSKLMK 69
            |:|  |:..|..|..:.......:.|.....|:..|      |||     ||...::.|
Yeast    62 NKVITEIFDATEDAKEADESERGMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGA------ 120

  Fly    70 VWCNQTLHDTYGSNLSAGG---LDLLWSCVVSVFLVGGAIGSLGGAG-AANKFGRKACFLICGAL 130
            .:........:||.....|   :...|...:::..:.|.|..|...| :.:..|.:...:|  ||
Yeast   121 FYALPIFQRKFGSQNDKTGEWEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLII--AL 183

  Fly   131 FTVGAVLF--FFCRAASSVEMLVIGRFVVGLASGLVTATLPMYLSEVAPMALRGTL--------- 184
            |.:.|..|  :||   :|:.|:.:|:.:.|:..|........|.||:.|:|||..|
Yeast   184 FFLAAFTFILYFC---NSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWL 245

  Fly   185 -GVFIAVGVTGGVVVGQVCSLANVFGTEDLWHYALTAYMFLILV-CYLPSYLFPESPKFLYIVKG 247
             |...|.|:        :.:....:...:|.:....|..:::.| ..|..:..||||.:| :.||
Yeast   246 FGQLFAAGI--------MKNSQKKYADSELGYKLPFALQWILPVPLALGIFFAPESPWWL-VKKG 301

  Fly   248 NRAAAKRELQRL---RGKDAEELIAQEM----AEMEAESNAKVQTSSFCDVLRDPRLTLPLIIVC 305
            ....|:|.|:|.   :|.:.|.|:..|:    ..::.|.....:..|:.|...|........|.|
Yeast   302 RFDEARRSLRRTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINRRRTRITC 366

  Fly   306 CFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQWANLGAGCLNLAVSLLGPWLMAKCNRRTLMMF 370
            ....||...| :.:..||...:||||:||..:...::...||.:..:.|..|......|..|..|
Yeast   367 LCWAGQATCG-SILIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAF 430

  Fly   371 SCALCSVFLFTIAFVLFYIDQVSWFAIACI----------VCIMGYIFFYQFGLGPIPYFIGAEL 425
            ..|..::..|.|.            .:.|.          ..:|...|||..|:.|:.:.:.:|:
Yeast   431 GLAFQTIVFFIIG------------GLGCSSTHGSKMGSGSLLMAVAFFYNLGIAPVVFCLVSEM 483

  Fly   426 FEVAPRS--------VAMSMGSLASWTCNFIIGISFPLLQNAWGAFVFLPFSITCVLLFLLTKFY 482
                |.|        :|.:..::.|..|:.:|.......:..|||.....:.:.|....:.....
Yeast   484 ----PSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVD 544

  Fly   483 LPETRGRDPSEVAPLVSKGFRSK 505
            ||||.|:...|:..|...|..::
Yeast   545 LPETAGKTFVEINELFKLGVSAR 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	106/483 (22%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	93/424 (22%)
MPH3	NP_012694.1	SP	72..556	CDD:273317	112/520 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840