DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut1 and HXT15

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_010036.1	Gene:	HXT15 / 851352	SGDID:	S000002404	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	561	Identity:	143/561 - (25%)
Similarity:	239/561 - (42%)	Gaps:	101/561 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AQQLYPQPNRVELLSAQTD----PSQKPRW-----------GN-------------LLLLVALAT 46
            ::|..|:.|...|.|:..|    |..:..|           ||             ::.|:....
Yeast     3 SEQSSPEINADNLNSSAADVHVQPPGEKEWSDGFYDKEVINGNTPDAPKRGFLGYLIIYLLCYPV 67

  Fly    47 TFGGAV---STGYCIGVINAPSKLMKVWCNQTLHDT---YGSNLSAGGLDLLWSCVVSVFLVGGA 105
            :|||.:   .:|...|.||..:  .|:......|.|   |.||:..|       .:|::|.||.:
Yeast    68 SFGGFLPGWDSGITAGFINMDN--FKMNFGSYKHSTGEYYLSNVRMG-------LLVAMFSVGCS 123

  Fly   106 IGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVE--MLVIGRFVVGLASGLVTATL 168
            ||.:..|..|:..||:...:|...::.|||::    :.:|:.:  ...:|:.:.||.:|..:...
Yeast   124 IGGVAFARLADTLGRRLAIVIVVLVYMVGAII----QISSNHKWYQYFVGKIIYGLGAGGCSVLC 184

  Fly   169 PMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDL-----WHYALTAYMFLILVC 228
            ||.|||:||..|||.|.....:.:|.|:.:| .||   |:||...     |...:.......|:.
Yeast   185 PMLLSEIAPTDLRGGLVSLYQLNMTFGIFLG-YCS---VYGTRKYSNTAQWRIPVGLCFLWALII 245

  Fly   229 YLPSYLFPESPKFLY-----------IVKGNRAAAKRELQRLRGKDAEELIAQEMAEME-AESNA 281
            .:...|.||||::|.           |.|.|:.:.:.....   |.|:|:.|..:|:.| .|::.
Yeast   246 IVGMLLVPESPRYLIECERHEEACVSIAKINKVSPEDPWVL---KQADEINAGVLAQRELGEASW 307

  Fly   282 KVQTSSFCDVLRDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQWANLGAGC 346
            |...|....||:  ||...:::....    ||:|.|..|:|..:||:..||:  |....::..|.
Yeast   308 KELFSVKTKVLQ--RLITGILVQTFL----QLTGENYFFFYGTTIFKSVGLT--DGFETSIVLGT 364

  Fly   347 LNLAVSLLGPWLMAKCNRRTLMMFSCA---LCSVFLFTIAFVLFY-------IDQVSWFAIACIV 401
            :|...:::...::.|..||..::|..|   .|.|...:|.....|       ..:.:..|:....
Yeast   365 VNFFSTIIAVMVVDKIGRRKCLLFGAASMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFT 429

  Fly   402 CIMGYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGISFPLLQNA---WGAF 463
            |.  |||.:.....|:.|.:.||.|....:|.|||:.:..:|...|:||...|.:..:   :..:
Yeast   430 CF--YIFCFATTWAPVAYIVVAESFPSKVKSKAMSISTAFNWLWQFLIGFFTPFITGSIHFYYGY 492

  Fly   464 VFLPFSITC-VLLFLLTKFYLPETRGRDPSEVAPLVSKGFR 503
            ||    :.| |.:||...|:||||.|....|:..|..:|.:
Yeast   493 VF----VGCLVAMFLYVFFFLPETIGLSLEEIQLLYEEGIK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	127/477 (27%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	109/418 (26%)
HXT15	NP_010036.1	MFS_HXT	62..524	CDD:340914	131/495 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840