DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut1 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_849265.2	Gene:	Slc2a12 / 353169	MGIID:	3052471	Length:	622	Species:	Mus musculus

Alignment Length:	563	Identity:	112/563 - (19%)
Similarity:	220/563 - (39%)	Gaps:	146/563 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 TTFGGAVS---TGYCIGVINAPSKLMKVWCNQTLHDTYGSNLSAGGLDLLWSCVVSVFLVGGAIG 107
            |:...|:|   .||.:|:|:.....::.....|.|:.              ..|||..|:|..:.
Mouse    47 TSVTAAISGLLVGYELGLISGALLQIRTLLALTCHEQ--------------EMVVSSLLIGAFLA 97

  Fly   108 SLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVEMLVIGRFVVGLASGLVTATLPMYL 172
            ||.|....:::||:...::...|..:|:::...   :.|..:|::||..:|::..|.:....:|:
Mouse    98 SLTGGVLIDRYGRRLAIILSSCLLGLGSLVLIM---SLSYTLLIMGRVAIGVSISLSSIATCVYI 159

  Fly   173 SEVAPMALRGTLGVFIAVGVTGGVVVGQVC--SLANVFGTEDLWHYALTAYMFLILVCYLPSYLF 235
            :|:||...||.|.....:.:..|::...:.  :.||:   .:.|.|.....:.|.::..:..|..
Mouse   160 AEIAPQHRRGLLVSLNELMIVTGILFAYISNYAFANI---SNGWKYMFGLVIPLGVLQAIAMYFL 221

  Fly   236 PESPKFLYIVKGNRAAAKRELQRLR--GKDAEELIAQEMAEMEAESNAKVQTS-SFCDVLRD--- 294
            |.||:|| ::||...:|.:.|::||  ....|||..       .:|:.|.:.. ||.|:.|.
Mouse   222 PPSPRFL-VMKGQEESAGKVLRKLRVISDTTEELTL-------IKSSLKDEYQYSFWDLFRSKDN 278

  Fly   295 --PRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGL-STVDAQWANLGAGCLNLAVSLLGP 356
              .|:.:.|.:|...    |.:|...|.:|:.::.:..|. |...|..|:.|.|.:.:..::...
Mouse   279 MRTRILIGLTLVFFV----QTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAT 339

  Fly   357 WLMAKCNRRTLMMFSCALCSVFLFTIAFV-------------------------LFY------ID 390
            .|:.....:|.:....::.|..|.|:..|                         :||      |.
Mouse   340 LLVDHIGSKTFLCIGSSVMSASLLTMGIVNLNINMNFTNICRSHSLLNQSLEEFVFYATGNLSIS 404

  Fly   391 QVS-----------------------------------------------------------WFA 396
            ..|                                                           |.:
Mouse   405 NSSLREHFKRITPYSKGSFMPMGNGMEPKGEMTFTSSLPNAGLSRTEHQGVTDTAVVPAAYKWLS 469

  Fly   397 IACIVCIMGYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGISF----PLLQ 457
            :|.::.   |:..:..||||:|:.:.:|:|....|..||::.|..:|..|.:|.::|    .|:.
Mouse   470 LASLLV---YVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGVNLLISLTFLTVTDLIG 531

  Fly   458 NAWGAFVFLPFSITCVLLFLLTKFYLPETRGRDPSEVAPLVSK 500
            .:|..|::...|:..:...:|   ::|||:|....:::..::|
Mouse   532 LSWVCFIYTIMSLASLAFVVL---FIPETKGCSLEQISVELAK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	108/546 (20%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	98/490 (20%)
Slc2a12	NP_849265.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sugar_tr	48..569	CDD:278511	110/558 (20%)
		MFS	49..>367	CDD:119392	78/349 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840