DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut1 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	165/509 - (32%)
Similarity:	255/509 - (50%)	Gaps:	55/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GNLLLLVALATTFGGAVSTGYCIGVINAPSKLMKVWCNQTL------------HDTYGSNL---- 84
            |.|...|..|..  |:...||.|||||||.:::.......|            :|..|::.
  Rat     8 GTLAFTVFTAVL--GSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIV 70

  Fly    85 ----------------SAGGLDLLWSCVVSVFLVGGAIGSLGGAGAANKFGRKACFLICGALFTV 133
                            ||..:.:|||..||.|.|||.:.|..|....:|.||....|...:|...
  Rat    71 TPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLT 135

  Fly   134 GAVLFFFCRAASSVEMLVIGRFVVGLASGLVTATLPMYLSEVAPMALRGTLGVFIAVGVTGGVVV 198
            ||:|....:...:..:::.||.|.||..||::..:|||:.|:||..|||.||....:.:..|:::
  Rat   136 GALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILI 200

  Fly   199 GQVCSLANVFGTEDLWHYAL-TAYMFLILVCYLPSYLF-PESPKFLYIVKGNRAAAKRELQRLRG 261
            .|:..|:.:.|.:|.||..| .:.:..:|.|.|  .|| ||||::||:.......||:.|:||||
  Rat   201 SQIAGLSFILGNQDYWHILLGLSAVPALLQCLL--LLFCPESPRYLYLKLEEEVRAKKSLKRLRG 263

  Fly   262 KDAEELIAQEMAEM--EAESNAKVQTSSFCDVLRDPRLTLPLIIVCCFHGGQQLSGINAIFYYSV 324
               .|.:.:::.||  |.|..:..|..|...:..||....|:::....|..||.||||.|||||.
  Rat   264 ---TEDVTKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYST 325

  Fly   325 SIFEKAGLSTVDAQWANLGAGCLNLAVSLLGPWLMAKCNRRTLM---MFSCALCSVFLFTIAFVL 386
            |||:.||:|  ...:|.:|.|.:|:..:.:...|:.|..||||.   |.....|:||: ::..||
  Rat   326 SIFQTAGIS--QPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFM-SLGLVL 387

  Fly   387 FYIDQVSWFAIACIVCIMGYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGI 451
              :|:.:|.:...:..|..::.|::.|.||||:|:.||.|...||..|:::.:.::|.|||||.:
  Rat   388 --LDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIAL 450

  Fly   452 SFPLLQNAWGAFVFLPFSITCVLLFLLTKFYLPETRGRDPSEVAPLVSKGFRSK 505
            .|..:.:..|.:||..|:...::..|.|.|.:|||:|:...|:|    ..||.|
  Rat   451 CFQYIADFLGPYVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIA----AEFRKK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	157/480 (33%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	133/392 (34%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	157/487 (32%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900