DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut1 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	178/484 - (36%)
Similarity:	265/484 - (54%)	Gaps:	25/484 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SAQTDPSQKPRWGNLLLLVALATTFGGAVSTGYCIGVINAPSKLMKVWCNQTLHDTYG----SNL 84
            |...:|.|:...|.|:|.|..|..  |::..||.|||||||.|:::...|.|.....|    .::
  Rat    10 SEDGEPPQQRVTGTLVLAVFSAVL--GSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSI 72

  Fly    85 SAGGLDLLWSCVVSVFLVGGAIGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVEM 149
            ..|.|..||:..|::|.|||.|.|......:...|||...|....|..:|..|.....||:|.|:
  Rat    73 PQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEI 137

  Fly   150 LVIGRFVVGLASGLVTATLPMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDLW 214
            |::|||::|..|||.:..:|||:.|:||..|||.||....:.:..|::|.||..|.::.||..||
  Rat   138 LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLW 202

  Fly   215 H--YALTAYMFLILVCYLPSYLFPESPKFLYIVKGNRAAAKRELQRLRG-KDAEELIAQ---EMA 273
            .  .|:|....|:.:..||  ..||||::|||::.....|::.|:||.| .|..:.:|:   |..
  Rat   203 PLLLAITVLPALLQLLLLP--FCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKR 265

  Fly   274 EMEAESNAKVQTSSFCDVLRDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQ 338
            ::|.|     :..|...:|.......||||.......||||||||:||||.||||.||:.  ...
  Rat   266 KLERE-----RPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVE--QPA 323

  Fly   339 WANLGAGCLNLAVSLLGPWLMAKCNRRTLMMFSCA-LCS-VFLFTIAFVLFYIDQVSWFAIACIV 401
            :|.:|||.:|...:|:...|:.:..||||.:...| :|. ..|.|:|.:|  :::|...:...||
  Rat   324 YATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLL--LERVPSMSYVSIV 386

  Fly   402 CIMGYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGISFPLLQNAWGAFVFL 466
            .|.|::.|::.|.||||:||.||||...||..||::...::||||||:|:.|..:.:|.|.:|||
  Rat   387 AIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFL 451

  Fly   467 PFSITCVLLFLLTKFYLPETRGRDPSEVA 495
            .|::..:..|:.|...:||||||...:::
  Rat   452 LFAVLLLGFFIFTFLRVPETRGRTFDQIS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	169/453 (37%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	146/393 (37%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13		1/2 (50%)
		Sugar_tr	27..483	CDD:278511	172/467 (37%)
		MFS	78..447	CDD:119392	141/379 (37%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337961
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	0.113	Inparanoid score	I2429
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900