DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut1 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_035530.2	Gene:	Slc2a1 / 20525	MGIID:	95755	Length:	492	Species:	Mus musculus

Alignment Length:	480	Identity:	187/480 - (38%)
Similarity:	276/480 - (57%)	Gaps:	17/480 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DPSQKPRWGNLLLLVALATTFGGAVSTGYCIGVINAPSKLMKVWCNQTLHDTYGSNLSAGGLDLL 92
            |||.|...|.|:|.|..|..  |::..||..||||||.|:::.:.|||.:..||..:.:..|..|
Mouse     2 DPSSKKVTGRLMLAVGGAVL--GSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGEPIPSTTLTTL 64

  Fly    93 WSCVVSVFLVGGAIGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVEMLVIGRFVV 157
            ||..|::|.|||.|||.......|:|||:...|:...|..|.|||..|.:...|.|||::|||::
Mouse    65 WSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVAAVLMGFSKLGKSFEMLILGRFII 129

  Fly   158 GLASGLVTATLPMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDLWHYALTA-Y 221
            |:..||.|..:|||:.||:|.||||.||....:|:..|:::.||..|.::.|..|||...|:. :
Mouse   130 GVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIF 194

  Fly   222 MFLILVCYLPSYLFPESPKFLYIVKGNRAAAKRELQRLRGKDAEELIAQEMAEMEAESNAKVQTS 286
            :..:|.|.|..:. ||||:||.|.:.....||..|::|||........|||.| |.....:.:..
Mouse   195 IPALLQCILLPFC-PESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKE-EGRQMMREKKV 257

  Fly   287 SFCDVLRDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQWANLGAGCLNLAV 351
            :..::.|.|....|::|.......||||||||:||||.|||||||:.  ...:|.:|:|.:|.|.
Mouse   258 TILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQ--QPVYATIGSGIVNTAF 320

  Fly   352 SLLGPWLMAKCNRRTLMMF---SCALCSVFLFTIAFVLFYIDQVSWFAIACIVCIMGYIFFYQFG 413
            :::..:::.:..||||.:.   ..|.|:| |.|||..|  ::::.|.:...||.|.|::.|::.|
Mouse   321 TVVSLFVVERAGRRTLHLIGLAGMAGCAV-LMTIALAL--LERLPWMSYLSIVAIFGFVAFFEVG 382

  Fly   414 LGPIPYFIGAELFEVAPRSVAMSMGSLASWTCNFIIGISFPLLQNAWGAFVFLPFSITCVLLFLL 478
            .||||:||.||||...||..|:::...::||.|||:|:.|..::...|.:||:.|::..||.|:.
Mouse   383 PGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIF 447

  Fly   479 TKFYLPETRGRDPSEVAPLVSKGFR 503
            |.|.:|||:||...|:|    .|||
Mouse   448 TYFKVPETKGRTFDEIA----SGFR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	174/445 (39%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	148/389 (38%)
Slc2a1	NP_035530.2	Sugar_tr	19..467	CDD:278511	176/460 (38%)
		MFS	62..450	CDD:119392	151/394 (38%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2506
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900