DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut1 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_523658.1	Gene:	sut1 / 35774	FlyBaseID:	FBgn0028563	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	516	Identity:	132/516 - (25%)
Similarity:	207/516 - (40%)	Gaps:	75/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSQKPRWGNL----LLLVALATTFGGAVSTGYCIGVINAPSKLMKVWCNQTLHDTYGSNLSAGGL 89
            |..:.|.|.|    :.|...|...|. .|.||.:...:.....::...:..||.| .|..|..|
Human    24 PGDRARVGTLQNKRVFLATFAAVLGN-FSFGYALVYTSPVIPALERSLDPDLHLT-KSQASWFG- 85

  Fly    90 DLLWSCVVSVFLVGGAIGSLGGAGAANKFGRKACFLICGALFTVGAVLFFFCRAASSVEMLVIGR 154
                    |||.:|.|.|.|......:..|||...:........|..|.   ..|..:.||::||
Human    86 --------SVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALM---AGAHGLWMLLLGR 139

  Fly   155 FVVGLASGLVTATLPMYLSEVAPMALRGTLGVFIAVGVTGGVVVGQVCSLANVFGTEDL------ 213
            .:.|.|.||..|.:|:|:||:||..:||.||.              ...|..|||:..|
Human   140 TLTGFAGGLTAACIPVYVSEIAPPGVRGALGA--------------TPQLMAVFGSLSLYALGLL 190

  Fly   214 --WHYALTAYMFLILVCYLPSYLFPESPKFLYIVKGNRAAAKRELQRLRGKDAEELIAQEMAEME 276
              |.:...|....:|:..|.....|.||:|| :.:|....|.|.|..|||.|.:  :..|..::
Human   191 LPWRWLAVAGEAPVLIMILLLSFMPNSPRFL-LSRGRDEEALRALAWLRGTDVD--VHWEFEQI- 251

  Fly   277 AESNAKVQTS--SFCDVLRDPRLTLPLIIVCCFHGGQQLSGINAIFYYSVSIFEKAGLSTVDAQW 339
             :.|.:.|:|  |:.:. |.|.:..|:.:.......|||:||..|..|..|||:...:.......
Human   252 -QDNVRRQSSRVSWAEA-RAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDD 314

  Fly   340 ANLGAGCLNLAVSLLGPWLMAKCNRRTLMMFSCALCSVFLFTIAFVLFY------------IDQV 392
            |.: .|.:.|...|:....|....|:.|:..|.|:......|:...:.:            ::..
Human   315 AAI-VGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESE 378

  Fly   393 SW-------------FAIACIVCIMGYIFFYQFGLGPIPYFIGAELFEVAPRSVAMSMGSLASWT 444
            ||             ..:..::..|.:|..|..|.|||.:.:.:|:..:..|.||..:..||||.
Human   379 SWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWL 443

  Fly   445 CNFIIGISFPLLQNAWGAFV-FLPFSITCVLLFLLTKFYLPETRGRDPSEVAPLVSKGFRS 504
            ..|::..||..:.:.:|..| |..|:..|::..:.|...:|||:||...::......|.||
Human   444 TAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut1	NP_523658.1	Sugar_tr	55..497	CDD:278511	121/477 (25%)
sut1	NP_523658.1	MFS	96..482	CDD:119392	108/421 (26%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		1/3 (33%)
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	125/488 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840