DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lig and UBAP2

DIOPT Version :9

Sequence 1:	NP_001260795.1	Gene:	lig / 35771	FlyBaseID:	FBgn0020279	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001356988.2	Gene:	UBAP2 / 55833	HGNCID:	14185	Length:	1119	Species:	Homo sapiens

Alignment Length:	1340	Identity:	370/1340 - (27%)
Similarity:	542/1340 - (40%)	Gaps:	353/1340 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HAAAAGKKGGQDASKTDKPEKAQPKATTEQLRIAQITNSTTEDPQINEKVLLLLTMTQRSEEEVC 104
            |...|.:|....|:::.:|:|...:||.||:|:||:. ....|.....||..|:.:|.::::|..
Human     9 HCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQVI-FDKNDSDFEAKVKQLMEVTGKNQDECI 72

  Fly   105 CALNECDYDLEAAANFLIEELPQGAFAKYEK---KRKNKAANNTADGAAGDGDWADGNGNADRRE 166
            .||::|:.|:..|.|.|:|  .......:|.   |:||.|..|:.              |.:.||
Human    73 VALHDCNGDVNKAINILLE--GNSDTTSWETVGCKKKNFAKENSE--------------NKENRE 121

  Fly   167 KSRNRSSNRGGTRGSSDSRGWRGRETRENERNQRESREPWSGQNAGQDRGD-DRANDNYRGQRNG 230
            |...:.|:||  ||:::.:|..|...||           :.|:..|.|... |:.:|  ||:|
Human   122 KKSEKESSRG--RGNNNRKGRGGNRGRE-----------FRGEENGIDCNQVDKPSD--RGKR-- 169

  Fly   231 GGRSGPGGGGRGGGFVSRSGRGGGR-----MGGRTGGPRGDRGSGGPGG----AYGSGRGGNANE 286
                     .||.||....|||.||     ||........|..|....|    .:.:.:.| |:|
Human   170 ---------ARGRGFGRGRGRGAGRFSTQGMGTFNPADYSDSTSTDVCGTKLVVWEAAQNG-ADE 224

  Fly   287 DHHEVELWDNT--IAQN-AEKQQQAHDDAW----GDWNNEEYEGSLKDSKVFTTSNLATQSAANV 344
            .   .||..||  |||: :.|.......||    .:|..|::...|.::||||.|:...::  ::
Human   225 G---TELASNTHNIAQDLSNKSSYGLKGAWKNSVEEWTTEDWTEDLSETKVFTASSAPAEN--HI 284

  Fly   345 VSGTGASVTA-----VP-----AAAGTEISAPPGLEHQLVQQGSHLEESSSSGPAAVTPPATLSG 399
            :.|....:.|     ||     .|...|.|...|....||...|......:.|          :|
Human   285 LPGQSIDLVALLQKPVPHSQASEANSFETSQQQGFGQALVFTNSQHNNQMAPG----------TG 339

  Fly   400 SATTPLLQYSAAVSNPPPQLQSQGTQSGAGTGA----------------SAAAGGGAGSTPSSFV 448
            |:|        ||::..||..|....||.|..|                .|.:.|...:|||:..
Human   340 SST--------AVNSCSPQSLSSVLGSGFGELAPPKMANITSSQILDQLKAPSLGQFTTTPSTQQ 396

  Fly   449 SAS--PDTFSS-----AASAAATLVHQAQKQQQLQQQTTPIKPSATLS-VEQSQYFNSLASQGVS 505
            :::  |.|.:|     ..|.::.|.|...|.|.        :||..|| :.|.|...|.|.....
Human   397 NSTSHPTTTTSWDLKPPTSQSSVLSHLDFKSQP--------EPSPVLSQLSQRQQHQSQAVTVPP 453

  Fly   506 PGSVPVQSAPAGYAQNPVAAYSQTSTSVGVSQYPNTYANVFASGTAAGAGTAEQSQQQPQIRRAR 570
            ||   ::|.|:.............||...:.|.|:|        |......:....|...|:.|:
Human   454 PG---LESFPSQAKLRESTPGDSPSTVNKLLQLPST--------TIENISVSVHQPQPKHIKLAK 507

  Fly   571 VKLPPPSKIPASAVEMPGDNALNNIGYLDVQFGALDFGTDDGFEPLPEKVGSGFSIDGQQQQQQP 635
            .::||.||||||||||||.   .::..|:||||||:||:    ||...:.||..|
Human   508 RRIPPASKIPASAVEMPGS---ADVTGLNVQFGALEFGS----EPSLSEFGSAPS---------- 555

  Fly   636 DDYQSKSQQQQQVTLAAGLQSSQISDALNAAGYTSRSTSQQQQGVSSAVNATIDQLTKSDPYGQT 700
                  |:...|:.::  |.|..:|:.||    ||.|       ::|||
Human   556 ------SENSNQIPIS--LYSKSLSEPLN----TSLS-------MTSAV---------------- 585

  Fly   701 GGSGNAYQNA-YQSS---GASKTASGFPTTAPGGYSSSTYANVQSSVANSYQQQGYGSYQPSSYQ 761
                   ||: |.:|   ..|.|:|...:.:|...||| |.  ||||.|..           .||
Human   586 -------QNSTYTTSVITSCSLTSSSLNSASPVAMSSS-YD--QSSVHNRI-----------PYQ 629

  Fly   762 QQAGSGAQSGTGAVSGGGGTATQNIPVGGSSSQNSTSVSTSSGVSSNSGSTGNGGVVSGQTGANQ 826
            ... |.::|..|.:..|.|        ||.|.|...:..|                    ||...
Human   630 SPV-SSSESAPGTIMNGHG--------GGRSQQTLDTPKT--------------------TGPPS 665

  Fly   827 AAVSNNNSVSGSS------SVSNVTAGVASGNVAGVGGGVS--QSGVSSGVGVPGGSASSVGVNV 883
            |..|.::..|.:|      |.|..|..:.|..::.:...:|  ||.:|:...: ..|.|....:|
Human   666 ALPSVSSLPSTTSCTALLPSTSQHTGDLTSSPLSQLSSSLSSHQSSLSAHAAL-SSSTSHTHASV 729

  Fly   884 NNNSSSASSVGAATVAQTATGTTAAVLASLTNKNTSSSNSSGSGGSAATTTGNASGQGAGASTGG 948
            .:.||..||         ||.:|||.       :.|||.|||:..|::..|.|:      ...||
Human   730 ESASSHQSS---------ATFSTAAT-------SVSSSASSGASLSSSMNTANS------LCLGG 772

  Fly   949 VGSSSGAGGAGSGGGSGSGLVPTNIQ------MVSQYIQTG----LPYYQQPVYSYEELQMMQQR 1003
            ..:|:.:..:.:.....||..|.|:.      :.:||: .|    ||.|  |:|.|:||||:|.|
Human   773 TPASASSSSSRAAPLVTSGKAPPNLPQGVPPLLHNQYL-VGPGGLLPAY--PIYGYDELQMLQSR 834

  Fly  1004 VPHVQGYYDLNYPPASLGAGRDNL-------GSVTYSAMNDGRFARTDNNSSPVGNVSSTMSQQA 1061
            :|  ..||.:.:...:..|.||..       |.||       :|.|.| ::||....:....||:
Human   835 LP--VDYYGIPFAAPTALASRDGSLANNPYPGDVT-------KFGRGD-SASPAPATTPAQPQQS 889

  Fly  1062 GSSA------PMLN--VPYAYFYGG----NVMPGSFQYGTPAIYPQIPAANTASGQQFPKPSY-- 1112
            .|..      |.:|  :|..|.|.|    ..||.:||||.....|...|.........|.|.:
Human   890 QSQTHHTAQQPFVNPALPPGYSYTGLPYYTGMPSAFQYGPTMFVPPASAKQHGVNLSTPTPPFQQ 954

  Fly  1113 SAGYG----STSYDTLSQTTQ--DYSKGGYSSSVNQQSKT------QTVSNQSQAGTGSDLTSSM 1165
            ::|||    ||.||.|:|.|.  |||||||:.|....:|:      :.||..|......|:|.|:
Human   955 ASGYGQHGYSTGYDDLTQGTAAGDYSKGGYAGSSQAPNKSAGSGPGKGVSVSSSTTGLPDMTGSV 1019

  Fly  1166 YGKGHVALNKVNSYEKQSFHSGTPPPFNMPN---------TQTAGGTSAQPYGMYLPMPAAGHHN 1221
            |       ||..:::||.||:||||||::|:         :..|.|.:..|:...||.....|..
Human  1020 Y-------NKTQTFDKQGFHAGTPPPFSLPSVLGSTGPLASGAAPGYAPPPFLHILPAHQQPHSQ 1077

  Fly  1222 MIHQPIHQDSNS-AGQRQQSTS-QSKS-AGKQGYSPS-YW 1257
            ::|..:.||:.| :|||.|.:| |.|| |.|..|..| ||
Human  1078 LLHHHLPQDAQSGSGQRSQPSSLQPKSQASKPAYGNSPYW 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lig	NP_001260795.1	UBA_UBP2_like	85..122	CDD:270463	11/36 (31%)
		CAF-1_p60_C	498..589	CDD:292150	28/90 (31%)
		DUF3697	575..607	CDD:289261	20/31 (65%)
UBAP2	NP_001356988.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/16 (25%)
		UBA_UBP2_like	53..90	CDD:270463	11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..202		34/131 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..476		24/101 (24%)
		DUF3697	512..541	CDD:372135	20/31 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..736		33/154 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..905		15/59 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..966		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	982..1020		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1082..1119		17/36 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159630
Domainoid	1	1.000	144	1.000	Domainoid score	I4615
eggNOG	1	0.900	-	-		E1_2C0H4
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4349
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47464
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003488
OrthoInspector	1	1.000	-	-		otm40356
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16308
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4985
SonicParanoid	1	1.000	-	-		X2380
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.980