DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and Zfp423

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001380647.1	Gene:	Zfp423 / 94188	RGDID:	621664	Length:	1292	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	156/855 - (18%)
Similarity:	262/855 - (30%)	Gaps:	280/855 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RSLKDAASSASESELQEPRSPTPTPTNLSTGPHSPPMTFRCERC-DSFETSSRASLLLHVVQCLA 110
            |:|:|..|..|:.|..|........:           .:.|:.| ..||  |.|.|..|......
  Rat    48 RALEDRNSVTSQEERNEDDEDVEDES-----------IYTCDHCQQDFE--SLADLTDHRAHRCP 99

  Fly   111 GQAAAAAAAAAASARLKSEDLQEPENM-------SLGHMEGGKG---DGQTGNGSSSSASSSPAG 165
            |........:..::...|:|:..|..|       .||..|||.|   ..|..:.|....|.....
  Rat   100 GDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRH 164

  Fly   166 NSGGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTT 230
            ..      ..|.:..|:|..|:..|.:..:..||...|||.|.|.|..|:..|.|.|||..|..|
  Rat   165 EQ------IHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKT 223

  Fly   231 HTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLVKT-------------------------- 269
            |:.:.|:.|.:|.|||....::::|.|.....:..|.|:
  Rat   224 HSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEK 288

  Fly   270 --------------------------------------------CPLCSYRAGSMKSLRIHFFNR 290
                                                        ||:|..:..|::.:..|..:.
  Rat   289 HVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSH 353

  Fly   291 HGIDLDN----PGPGGTSSLLLALESQASAAAAAAAASYVPPGLSP----VPVQSQSQQQQQQQV 347
            ...|..|    |.|     :|.::.|.:||...::|:  |..|.:|    .|::.|.:.:
  Rat   354 RQPDSSNHSVSPDP-----VLGSVASMSSATPDSSAS--VERGSTPDSTLKPLRGQKKMR----- 406

  Fly   348 APPASDSGESMRSLENATP-------------PMHFLTPHVE----------------------- 376
                 |.|:|...:..:.|             .:|..|.|.:
  Rat   407 -----DDGQSWSKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNE 466

  Fly   377 -ISTLGES--------GNTELFNLICVWRESALQGNNNNNNN---NNCATNNNNNINGASNNCNS 429
             :..|.:|        ||...|:  |.:........|:...:   ::|..|.|......:..||.
  Rat   467 HVRKLHKSHAYPVMQFGNISAFH--CNYCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQ 529

  Fly   430 ISNG------------NAESNGDKVKDRALIMQSPVELPMD----------CNTKATPITSSTTA 472
            .|.|            .|..:....|     ::|||..|..          |..  :||..|..
  Rat   530 CSMGFLTESSLTEHIQQAHCSVGSTK-----LESPVIQPTQSFMEVYSCPYCTN--SPIFGSIL- 586

  Fly   473 SSLSGGLKSHHQH-PHHHHHHHHHHENHITPSISLIPIKQEPMSEDMDKKDLMNGSDPSSDTEQA 536
             .|:..:|.:|:: |..|.......::.::..:.:...|::.:|...:  .:.||..|.:..:..
  Rat   587 -KLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLSGSAN--SISNGEYPCNQCDLK 648

  Fly   537 SNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNG 601
            .:|..|...:           ||..|...|:::.|.:...         :.::..|:|.:...:.
  Rat   649 FSNFESFQTH-----------LKLHLELLLRKQACPQCKE---------DFDSQESLLQHLTVHY 693

  Fly   602 SGRGSPGVNGGSGGGGGGGPPTPAT----PSATNGASSTP-------------ICNGTITSTGQD 649
            .                    |.:|    .|.....||..             :.:.|:.....|
  Rat   694 M--------------------TTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFD 738

  Fly   650 GDLLI---------NRKLILTCHFCGIEFPDETLYFLH-KGCHCESNP---WRCNICGEQLNNVY 701
            ..:.|         |.|.:..|..|..:|..|....:| |..|. .||   .:|..|||..:...
  Rat   739 SKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHL-GNPAKAHKCIFCGETFSTEV 802

  Fly   702 EFNSHLLSKS 711
            |...|:.:.|
  Rat   803 ELQCHITTHS 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..255	CDD:275368	5/15 (33%)
		C2H2 Zn finger	662..689	CDD:275371	9/30 (30%)
		C2H2 Zn finger	690..712	CDD:275371	7/22 (32%)
Zfp423	NP_001380647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..70		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..123		3/27 (11%)
		C2H2 Zn finger	148..168	CDD:275368	3/25 (12%)
		C2H2 Zn finger	176..196	CDD:275368	5/19 (26%)
		COG5048	202..603	CDD:227381	75/428 (18%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..292	CDD:275368	0/18 (0%)
		C2H2 Zn finger	419..440	CDD:275368	2/20 (10%)
		C2H2 Zn finger	451..475	CDD:275368	1/23 (4%)
		C2H2 Zn finger	490..509	CDD:275368	2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..635		4/38 (11%)
		C2H2 Zn finger	672..692	CDD:275368	3/28 (11%)
		C2H2 Zn finger	702..723	CDD:275368	3/20 (15%)
		C2H2 Zn finger	730..751	CDD:275368	3/20 (15%)
		C2H2 Zn finger	760..781	CDD:275368	6/20 (30%)
		C2H2 Zn finger	791..811	CDD:275368	6/19 (32%)
		C2H2 Zn finger	817..835	CDD:275368
		C2H2 Zn finger	896..917	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	969..989	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1171
		C2H2 Zn finger	1208..1228	CDD:275368
		C2H2 Zn finger	1239..1260	CDD:275368
		C2H2 Zn finger	1269..1285	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930