Protein Alignment CG12769 and Zfp423

DIOPT Version :9

• Sequence 1: NP_001286181.1
• Gene: CG12769 / 35770
• FlyBaseID: FBgn0033252
• Length: 713
• Species: Drosophila melanogaster
• Sequence 2: XP_011246862.1
• Gene: Zfp423 / 94187
• MGIID: 1891217
• Length: 1312
• Species: Mus musculus
• Alignment Length: 885
• Identity: 165/885 - (18%)
• Similarity: 276/885 - (31%)
• Gaps: 273/885 - (30%)

  Fly     9 ASGMELALKDPSPTVGGGIIVDMTPTTAALLHHNAMALRSLKDAASSASESELQEPRSPTPTPTN 73
            ||...||. |.|....||:  :..|..      :....|:|:|..|..|:.|..|........:
Mouse    39 ASDFSLAW-DSSVAAAGGL--EGEPEC------DRKTSRALEDRNSVTSQEERNEDDEDVEDES- 93

  Fly    74 LSTGPHSPPMTFRCERC-DSFETSSRASLLLHVVQCLAGQAAAAAAAAAASARLKSEDLQEPENM 137
                      .:.|:.| ..||  |.|.|..|......|........:..::...|:|:..|..|
Mouse    94 ----------IYTCDHCQQDFE--SLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQM 146

  Fly   138 -------SLGHMEGGKG---DGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSN 192
                   .||..|||.|   ..|..:.|....|.......      ..|.:..|:|..|:..|.:
Mouse   147 IGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRHEQ------IHSDKLPFKCTFCSRLFKH 205

  Fly   193 GANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQ 257
            ..:..||...|||.|.|.|..|:..|.|.|||..|..||:.:.|:.|.:|.|||....::::|.|
Mouse   206 KRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQ 270

  Fly   258 NEHVGQHDLVKT----------------------------------------------------- 269
            .....:..|.|:
Mouse   271 AHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDE 335

  Fly   270 -----------------CPLCSYRAGSMKSLRIHFFNRHGIDLDN----PGPGGTSSLLLALESQ 313
                             ||:|..:..|::.:..|..:....|..|    |.|     :|.::.|.
Mouse   336 STLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDP-----VLGSVASM 395

  Fly   314 ASAAAAAAAASYVPPGLSP----VPVQSQSQQQQQQQVAPPA----------------------- 351
            :||...::|:  |..|.:|    .|::.|.:.:...|..|..
Mouse   396 SSATPDSSAS--VERGSTPDSTLKPLRGQKKMRDDGQSWPKVVYSCPYCSKRDFTSLAVLEIHLK 458

  Fly   352 ---SDSGESMRSLE---NATPPMHFLTPHVEISTLGES--------GNTELFNLICVWRESALQG 402
               :|..:...:.:   ::.|.::.|..||.  .|.:|        ||...|:  |.:.......
Mouse   459 TIHADKPQQSHTCQICLDSMPTLYNLNEHVR--KLHKSHAYPVMQFGNISAFH--CNYCPEMFAD 519

  Fly   403 NNNNNNN---NNCATNNNNNINGASNNCNSISNG------------NAESNGDKVKDRALIMQSP 452
            .|:...:   ::|..|.|......:..||..|.|            .|..:....|     ::||
Mouse   520 INSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTK-----LESP 579

  Fly   453 VELPMD----------CNTKATPITSSTTASSLSGGLKSHHQH-PHHHHHHHHHHENHITPSISL 506
            |..|..          |..  :||..|..  .|:..:|.:|:: |..|.......::.::..:.:
Mouse   580 VVQPTQSFMEVYSCPYCTN--SPIFGSIL--KLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEV 640

  Fly   507 IPIKQEPMSEDMDKKDLMNGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRIC 571
            ...|::.:|...:  .:.||..|.:..:...:|..|...:           ||..|...|:::.|
Mouse   641 SSPKRQRLSGSAN--SISNGEYPCNQCDLKFSNFESFQTH-----------LKLHLELLLRKQAC 692

  Fly   572 AKANNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGGGGPPTPAT----PSATNG 632
            .:...         :.::..|:|.:...:..                    |.:|    .|....
Mouse   693 PQCKE---------DFDSQESLLQHLTVHYM--------------------TTSTHYVCESCDKQ 728

  Fly   633 ASSTP-------------ICNGTITSTGQDGDLLI---------NRKLILTCHFCGIEFPDETLY 675
            .||..             :.:.|:.....|..:.|         |.|.:..|..|..:|..|...
Mouse   729 FSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADL 793

  Fly   676 FLH-KGCHCESNP---WRCNICGEQLNNVYEFNSHLLSKS 711
            .:| |..|. .||   .:|..|||..:...|...|:.:.|
Mouse   794 QVHVKHSHL-GNPAKAHKCIFCGETFSTEVELQCHITTHS 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..255	CDD:275368	5/15 (33%)
		C2H2 Zn finger	662..689	CDD:275371	9/30 (30%)
		C2H2 Zn finger	690..712	CDD:275371	7/22 (32%)
Zfp423	XP_011246862.1	C2H2 Zn finger	168..188	CDD:275368	3/25 (12%)
		C2H2 Zn finger	196..216	CDD:275368	5/19 (26%)
		COG5048	222..623	CDD:227381	75/420 (18%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..312	CDD:275368	0/18 (0%)
		C2H2 Zn finger	439..460	CDD:275368	0/20 (0%)
		C2H2 Zn finger	471..495	CDD:275368	5/25 (20%)
		C2H2 Zn finger	510..529	CDD:275368	2/18 (11%)
		C2H2 Zn finger	692..712	CDD:275368	3/28 (11%)
		C2H2 Zn finger	722..743	CDD:275368	3/20 (15%)
		C2H2 Zn finger	750..771	CDD:275368	3/20 (15%)
		C2H2 Zn finger	780..801	CDD:275368	6/20 (30%)
		C2H2 Zn finger	811..831	CDD:275368	6/19 (32%)
		C2H2 Zn finger	837..855	CDD:275368
		C2H2 Zn finger	916..937	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	989..1009	CDD:275368
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842432
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930