DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and ZNF112

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001335210.1	Gene:	ZNF112 / 7771	HGNCID:	12892	Length:	930	Species:	Homo sapiens

Alignment Length:	233	Identity:	63/233 - (27%)
Similarity:	94/233 - (40%)	Gaps:	49/233 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 NLSTGPHSPPMTFRCERCD-SFETSS--RASLLLHV-------VQCLAGQAAAAAAAAAASARLK 127
            |:....|:....::||.|| .|..||  :|...:|.       .:|..|.:             :
Human   558 NVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEECGKGFS-------------R 609

  Fly   128 SEDLQEPENMSLGHM-----EGGKGDGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCN 187
            :..||..:.:..|..     |.|||         .|.||...|:.....|     .|.|:|:.|.
Human   610 NSYLQGHQRVHTGEKPYKCEECGKG---------FSRSSHLQGHQRVHTG-----EKPFKCEECG 660

  Fly   188 MKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAM 252
            ..||...|::.|:..|||.|||:|..|.|.|.:...|..|...||...||.|..|.:.|.::..:
Human   661 KGFSWSFNLQIHQRVHTGEKPYKCEECGKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYL 725

  Fly   253 RAHFQNEHVGQHDLVKTCPLC----SYRAGSMKSLRIH 286
            ::| |:.|.|:...:  |.:|    |.||......|:|
Human   726 QSH-QSVHSGERPYI--CEVCGKGFSQRAYLQGHQRVH 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	6/19 (32%)
		zf-H2C2_2	195..218	CDD:290200	11/22 (50%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	3/15 (20%)
		C2H2 Zn finger	662..689	CDD:275371
		C2H2 Zn finger	690..712	CDD:275371
ZNF112	NP_001335210.1	KRAB	25..85	CDD:214630
		C2H2 Zn finger	250..269	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	305..321	CDD:275368
		C2H2 Zn finger	350..370	CDD:275368
		COG5048	401..773	CDD:227381	63/233 (27%)
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
		C2H2 Zn finger	520..536	CDD:275368
		C2H2 Zn finger	544..564	CDD:275368	1/5 (20%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		C2H2 Zn finger	600..620	CDD:275368	4/32 (13%)
		C2H2 Zn finger	628..648	CDD:275368	8/28 (29%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
		C2H2 Zn finger	712..732	CDD:275368	5/20 (25%)
		C2H2 Zn finger	740..760	CDD:275368	6/19 (32%)
		C2H2 Zn finger	768..788	CDD:275368
		SFP1	<780..873	CDD:227516
		C2H2 Zn finger	796..816	CDD:275368
		C2H2 Zn finger	824..844	CDD:275368
		C2H2 Zn finger	852..872	CDD:275368
		zf-H2C2_2	864..888	CDD:316026
		C2H2 Zn finger	880..900	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910