DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and ZNF225

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001308614.1	Gene:	ZNF225 / 7768	HGNCID:	13018	Length:	706	Species:	Homo sapiens

Alignment Length:	644	Identity:	119/644 - (18%)
Similarity:	181/644 - (28%)	Gaps:	219/644 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 KSEDL--QEPENMSLGHMEGGKGDGQTGNGSSSSAS-------------SSPAGNSGGGGGGNSS 176
            |.:|:  |....:|:.|:.....:|:|...|.|..|             |......|.....:|:
Human   126 KQDDMPCQVDAGLSIIHVRQKPSEGRTCKKSFSDVSVLDLHQQLQSREKSHTCDECGKSFCYSSA 190

  Fly   177 SR---------KVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHT 232
            .|         |::.||||..:|:..::::.|:..|||.||::|..|.|.|.|:..|..|...||
Human   191 LRIHQRVHMGEKLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKCEQCGKGFSRRSGLYVHRKLHT 255

  Fly   233 KTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLCSYRAGSMKSLRIHFFNRHGIDLDN 297
            ...|:.|..|.:.|.....::.| |..|.|:...  .|.:|.....|..:|     |||.:....
Human   256 GVKPHICEKCGKAFIHDSQLQEH-QRIHTGEKPF--KCDICCKSFRSRANL-----NRHSMVHMR 312

  Fly   298 PGP------GGTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPP--ASDS 354
            ..|      |.:..|..||.|................|...:..|...:.|.......|  ..:.
Human   313 EKPFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECGKRFIYRQDLYKHQIDHTGEKPYNCKEC 377

  Fly   355 GESMRSLENATPPMHFLTPHVEISTLGESGNTELFNLICVWRESALQGNNNNNNNNNCATNNNNN 419
            |:|.|....       |:.||.:    .||.|   ...|                ..|.
Human   378 GKSFRWASG-------LSRHVRV----HSGET---TFKC----------------EECG------ 406

  Fly   420 INGASNNCNSISNGNAESNGDKVKDRALIMQSPVELPMDCNTKATPITSSTTASSLSGGLK---- 480
             .|...|....|:..|.| |:|              |..|             .....|.|
Human   407 -KGFYTNSQRYSHQRAHS-GEK--------------PYRC-------------EECGKGYKRRLD 442

  Fly   481 -SHHQHPHHHHHHHHHHE------------NHITPSISLIPIKQEPMSEDMDKKDLMNGSDPSSD 532
             ..||..|.....::..|            ||                     :.:.:|..|...
Human   443 LDFHQRVHRGEKPYNCKECGKSFGWASCLLNH---------------------QRIHSGEKPFKC 486

  Fly   533 TE--QASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNSVLS 595
            .|  :....|:....:.|:.|..|  |.|           |.:...|.|:|:........::.:.
Human   487 EECGKRFTQNSQLYTHRRVHSGEK--PFK-----------CEECGKRFTQNSQLYSHRRVHTGVK 538

  Fly   596 NSLSNGSGRGSPGVNGGSGGGGGGGPPTPATPSATNGASSTPICNGTITSTGQDGDLLINRKLIL 660
            .......|:|                                                .|.|..|
Human   539 PYKCEECGKG------------------------------------------------FNSKFNL 555

  Fly   661 -------------TCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSH 706
                         .|..||..|...:....||..|.:..|::|..||::.....:.:||
Human   556 DMHQRVHTGERPYNCKECGKSFSRASSILNHKRLHGDEKPFKCEECGKRFTENSQLHSH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	6/19 (32%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	7/19 (37%)
		C2H2 Zn finger	239..255	CDD:275368	3/15 (20%)
		C2H2 Zn finger	662..689	CDD:275371	8/26 (31%)
		C2H2 Zn finger	690..712	CDD:275371	5/17 (29%)
ZNF225	NP_001308614.1	KRAB	8..48	CDD:307490
		C2H2 Zn finger	153..170	CDD:275368	3/16 (19%)
		C2H2 Zn finger	178..198	CDD:275368	3/19 (16%)
		COG5048	202..634	CDD:227381	105/568 (18%)
		C2H2 Zn finger	206..226	CDD:275368	6/19 (32%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	5/20 (25%)
		C2H2 Zn finger	290..310	CDD:275368	7/24 (29%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		C2H2 Zn finger	346..366	CDD:275368	3/19 (16%)
		C2H2 Zn finger	374..394	CDD:275368	6/30 (20%)
		C2H2 Zn finger	402..422	CDD:275368	5/42 (12%)
		C2H2 Zn finger	430..450	CDD:275368	5/32 (16%)
		C2H2 Zn finger	458..478	CDD:275368	3/40 (8%)
		C2H2 Zn finger	486..506	CDD:275368	3/19 (16%)
		C2H2 Zn finger	514..534	CDD:275368	4/19 (21%)
		C2H2 Zn finger	542..562	CDD:275368	5/67 (7%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..618	CDD:275368	5/17 (29%)
		C2H2 Zn finger	626..646	CDD:275368
		C2H2 Zn finger	654..672	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910