DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and Zfp788

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001347603.1	Gene:	Zfp788 / 67607	MGIID:	1914857	Length:	884	Species:	Mus musculus

Alignment Length:	611	Identity:	121/611 - (19%)
Similarity:	190/611 - (31%)	Gaps:	173/611 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 SSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCP 240
            :..|.:||..|...|...::..|||..|||.|||||:.|.|.|.....|..|..||:...||.|.
Mouse   317 TGEKPYECKQCGKAFRVNSSFWRHKKVHTGEKPYECKQCGKSFIYPSLLQTHERTHSAEKPYSCK 381

  Fly   241 ICNRGFQRQIAMRAHFQNEHVGQ------------------------HDLVKT--CPLCSYRAGS 279
            .|.:.|:...::|.|.:| |.|:                        |..||.  |..|......
Mouse   382 QCGKAFKSHSSLRVHERN-HTGKKPYECKQCGRSFIYPCLLQIHERTHSGVKPYGCKQCGKAFRR 445

  Fly   280 MKSLRIH------------------FFNRHGIDLDNPGPGGTSSLLLALESQASAAAAAAAASYV 326
            :..||:|                  |.||:.:.:......|.......:.|:|          :|
Mouse   446 LSDLRVHERTHTGEKPYECKQCAKSFINRYLLKMHQKSHTGEKPYKCKICSKA----------FV 500

  Fly   327 PPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMHFLTPHVEISTLGESGNTELFNL 391
            .|.|..:..:|.:.::..     |.....::            |:.|  .:..|.|..:|.....
Mouse   501 YPSLLKLHERSHTGEKPY-----PCKQCDKA------------FIFP--SLLKLHERTHTGEKPY 546

  Fly   392 ICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCNSISNGNAESNGDKVKDRALIMQSPVELP 456
            .|.....|.:..|:...:....|:....:      |...|             :|.|.|..::|.
Mouse   547 ACKQCGEAFKSYNSLQRHKRIHTDVKAYV------CKHCS-------------KAFICQRSLQLH 592

  Fly   457 MDCNTKATPITSSTTASSLSGGLKSHHQHPHHHHHHHHHHENH--ITPSISLIPIKQEPMS---- 515
            ...:|...|.......:|.               .:|:..:.|  |....:|...||...|
Mouse   593 NRTHTGEKPYKCEQCGNSF---------------RYHNSLQRHKIIHTGKNLYECKQCDRSFIYP 642

  Fly   516 ---EDMDKKDLMNGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKA--- 574
               :..|:..  :|..|...|:        ...:....||:::........:....:.|.||
Mouse   643 YLLQIHDRTH--SGGKPYECTQ--------CGKSYIYPSLLRIHERTHSAEKPYSCKQCGKAFKS 697

  Fly   575 --NNRI-TRNAT---PLESNN-NNSVLSNSLSNGSGRGSPGVNGGSGGGGGGGPPTPATPSATNG 632
              :.|: .||.|   |.|... ..|.:...|.....|...||........|         .|..|
Mouse   698 HSSLRVHERNHTGEKPYECKQCGRSFIYPCLLQTHERIHSGVKPYECKQCG---------KAFRG 753

  Fly   633 ASSTPICNGTITSTGQDGDLLINRKL-----ILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNI 692
            .||                ..:::||     ...|..||..|...:|..:|:..|....|:.|..
Mouse   754 HSS----------------FRVHKKLHSGEKPYECKQCGKCFIYPSLLRMHERTHSSEKPYDCKQ 802

  Fly   693 CGEQLNN-----VYEFNSHLLSKSHQ 713
            ||:...:     .:|.| |:..||:|
Mouse   803 CGKAFKSRSSLREHERN-HIEEKSYQ 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	6/19 (32%)
		zf-H2C2_2	195..218	CDD:290200	13/22 (59%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	4/15 (27%)
		C2H2 Zn finger	662..689	CDD:275371	8/26 (31%)
		C2H2 Zn finger	690..712	CDD:275371	7/26 (27%)
Zfp788	NP_001347603.1	KRAB	23..64	CDD:307490
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		zf-H2C2_2	308..332	CDD:316026	4/14 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	336..361	CDD:316026	14/24 (58%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	380..400	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..428	CDD:275368	0/19 (0%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	464..484	CDD:275368	3/19 (16%)
		COG5048	488..883	CDD:227381	76/439 (17%)
		C2H2 Zn finger	492..512	CDD:275368	5/29 (17%)
		C2H2 Zn finger	520..540	CDD:275368	4/33 (12%)
		C2H2 Zn finger	548..568	CDD:275368	3/19 (16%)
		C2H2 Zn finger	576..596	CDD:275368	6/32 (19%)
		C2H2 Zn finger	604..624	CDD:275368	3/34 (9%)
		C2H2 Zn finger	632..652	CDD:275368	4/19 (21%)
		C2H2 Zn finger	660..680	CDD:275368	3/27 (11%)
		C2H2 Zn finger	688..708	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..736	CDD:275368	3/19 (16%)
		C2H2 Zn finger	744..764	CDD:275368	6/44 (14%)
		C2H2 Zn finger	772..792	CDD:275368	6/19 (32%)
		C2H2 Zn finger	800..820	CDD:275368	5/20 (25%)
		C2H2 Zn finger	828..848	CDD:275368	121/611 (20%)
		C2H2 Zn finger	856..876	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910