DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and ikzf4

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_005162323.1	Gene:	ikzf4 / 566844	ZFINID:	ZDB-GENE-180319-1	Length:	572	Species:	Danio rerio

Alignment Length:	715	Identity:	151/715 - (21%)
Similarity:	236/715 - (33%)	Gaps:	207/715 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LKDAASSASESE-LQEPRSPT-PTPTNLSTGPHSPPMTFRCERCDSFETSSRASLLLHVVQCLAG 111
            :..:..|::|.| ....|.|| .||.:..:.|.      |....:|.:           |:..:.
Zfish    13 MSGSGDSSTEREFFAGLRGPTVSTPNSQQSSPS------RSLSANSIK-----------VELYSD 60

  Fly   112 QAAAAAAAAAASARLKSE-------DLQEPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNSGG 169
            :.|..|.........|.|       ||.|...:   .|.||. .||.|:|....|||.||
Zfish    61 EEAGGAPLVERRVGEKDEGWKDEKGDLAEDGGV---EMVGGT-RGQAGSGCGEMASSEPA----- 116

  Fly   170 GGGGNSSSRKVFECDVCNMKFSNGAN-MRRHKMRHT-----GVKPYECRVCQKRFFRKDHLAEHF 228
            ..|.........:||:|.| ...|.| :..||..||     |.:|::|..|...|.:|.:|..|.
Zfish   117 SPGPIRLPNGKLKCDICGM-ICIGPNVLMVHKRSHTVLVSVGERPFQCNQCGASFTQKGNLLRHI 180

  Fly   229 TTHTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLCSYRAGSMK---SLRIHFFNR 290
            ..|:...|:.||.||...:|:.|:..|.:...|....:.|... |||...|.|   :|..|....
Zfish   181 KLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYK-CSYCGRSYKQQSTLEEHRERC 244

  Fly   291 HGIDLDNPGPGGTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSG 355
            |             |.|.:|:.|              |..:..|...:.....:....|....|.
Zfish   245 H-------------SYLQSLDHQ--------------PAHNTQPTHGEESHNVEMISEPLIQSSS 282

  Fly   356 ESMRSLE----------NATPPMHFLTPHVEISTLGES-----GNTELFNLICVWRESALQGNNN 405
            |.|..::          .:||.......|:.:: :.|:     .|.:        :|..|..::.
Zfish   283 EKMTFIDRLANSITKRKRSTPQKFLGEKHMRLN-ISEAPYDLDPNPD--------KEGDLLLSHP 338

  Fly   406 NNNNNNCATNNNNNINGASNNCNSISNGNAESNGDKVKDRALIMQSPVELPMDCNTKATPITSST 470
            ..:....|......:.|.....|.:             |.:..::.|..  ..|.::.||:.||.
Zfish   339 EGDPAALAEMGGRFMRGPRGGSNDV-------------DPSRSLRMPPH--SACLSEFTPVISSV 388

  Fly   471 TASSLSGGLKSHHQHPHHHHHHHHHHENHITP-----------SISLIPIKQEPMSEDMDKKDLM 524
                          :|            ||||           |:.|...:.....||:
Zfish   389 --------------YP------------HITPLGQRLNCAGGISMGLAGREAGEGHEDL------ 421

  Fly   525 NGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNN 589
                ||:.:..||.:|....:.:               .|.:....|      :..:|.|...|:
Zfish   422 ----PSTRSRAASPSNGYQDSTD---------------TESMAEEQC------VITSAPPGNLNH 461

  Fly   590 NNSVLSNSLSNGSGRGSPG------VNGGSGGGGGGGPPTPATPSATNGASSTPICNGTITSTGQ 648
                      .|..|.||.      :.|....|..||.||.|:|       .:|:....:.....
Zfish   462 ----------RGRDRHSPSHAKEMDIEGDREKGVPGGLPTKASP-------RSPLTREAMQVVDG 509

  Fly   649 DGDLLINRKLILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSKSHQ 713
            :|..:.:    ..|..|.|.|.|..::.:|.|||....|:.|||||.:..:.|||:||::...||
Zfish   510 EGRPVRS----FRCEHCRIFFLDHVMFTIHMGCHGFRQPFECNICGHRSQDRYEFSSHIVRGEHQ 570

Fly 714 713
Zfish 571 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	8/20 (40%)
		zf-H2C2_2	195..218	CDD:290200	9/28 (32%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	6/15 (40%)
		C2H2 Zn finger	662..689	CDD:275371	10/26 (38%)
		C2H2 Zn finger	690..712	CDD:275371	10/21 (48%)
ikzf4	XP_005162323.1	C2H2 Zn finger	130..150	CDD:275368	8/20 (40%)
		zf-H2C2_2	143..172	CDD:290200	9/28 (32%)
		COG5048	<146..337	CDD:227381	48/227 (21%)
		zf-C2H2	161..183	CDD:278523	6/21 (29%)
		C2H2 Zn finger	163..183	CDD:275368	6/19 (32%)
		zf-H2C2_2	175..200	CDD:290200	8/24 (33%)
		C2H2 Zn finger	191..211	CDD:275368	7/19 (37%)
		C2H2 Zn finger	224..245	CDD:275368	7/20 (35%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	547..564	CDD:275368	9/16 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4630
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050