DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and si:ch211-216l23.1

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_005159186.1	Gene:	si:ch211-216l23.1 / 566696	ZFINID:	ZDB-GENE-060503-121	Length:	1372	Species:	Danio rerio

Alignment Length:	840	Identity:	174/840 - (20%)
Similarity:	263/840 - (31%)	Gaps:	299/840 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DAASSASESELQEPR--------SPTPTPTNLSTGPHSPPMTFRCERC-DSFETSSRASLLLH-V 105
            |||.|..:|:.:|.|        |.|.....:..........|.|:.| ..||  ..|.|..| .
Zfish    34 DAAVSERDSDRKESRAVGEDGEQSVTSHDERVGEEDLDDDSIFTCDNCQQDFE--CLADLTEHRT 96

  Fly   106 VQCLA-GQAAAAAAAAAASARLKSEDLQEPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNSGG 169
            ..|.| |......:..|:|.  .|:|:..|..|        .|||....|..:       |...|
Zfish    97 NHCPADGDDDPGLSWVASSP--SSKDVASPSQM--------LGDGCCDMGMGT-------GEEEG 144

  Fly   170 GGG--------GNSSSR-------------KV-FECDVCNMKFSNGANMRRHKMRHTGVKPYECR 212
            |.|        ..|.||             |: |:|..|:..|.:..:..||...|||.|.|.|:
Zfish   145 GSGLPYPCQFCDKSFSRLSYLKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHVKLHTGDKKYSCQ 209

  Fly   213 VCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQ-----NEHVGQHDLVK---- 268
            .|:..|.|.|||..|..||:.:.|:.|.||.|||....::::|.|     .||:.:.|..|
Zfish   210 ECEAAFSRSDHLKIHLKTHSSSKPFKCSICKRGFSSTSSLQSHMQAHRKNKEHLAKKDQGKRDGS 274

  Fly   269 ----------------------------------------------------------------- 268

Zfish   275 SSDVTEQDQDLYMCDYCEETFSQTDELEKHVLTQHPQLSDRAELQCIHCPEIFSDEGTLLTHIDR 339

  Fly   269 -------TCPLCSYRAGSMKSLRIHFFNRHGIDLDN----PGP--GGTSSLLLAL-ESQASAAAA 319
                   .||:|:.:..|::.:..|..:....|..|    |.|  |..:|:..|. :|.||....
Zfish   340 THANKKHKCPMCAEQFPSVEDVYCHLDSHRQPDSSNHSASPDPVLGSVASMSSATPDSSASLERG 404

  Fly   320 AAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASD------SGE--------SMRSLEN-ATPPMH 369
            :...|.:.||            |.::::| |:||      ||:        |.|...: |...:|
Zfish   405 STPDSTLKPG------------QSRRKLA-PSSDHDDGTWSGKVTYSCPYCSKRDFNSLAVLEIH 456

  Fly   370 FLTPHVE-----------ISTLGESGNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNI--- 420
            ..|.|.:           :.||     ..|:||           |.:....:..:.|:.:|.
Zfish   457 LKTIHADKPQQSHTCQLCLETL-----PTLYNL-----------NEHVRKAHRSSGNSASNFPLL 505

  Fly   421 ---NGASNNCNSISNGNAESNGDKVKDRALIMQSPVELPMDCNTKATPITSSTT--------ASS 474
               |.::.:||...:..|:.|.         :|..:.: ..|.:... :..|||        .:.
Zfish   506 QFSNVSAFHCNYCPDMFADINS---------LQEHIRV-SHCLSGGV-VAGSTTLEGNHAFFCNQ 559

  Fly   475 LSGGLKSHHQHPHHHHHHHHHHENHIT--------PSISLIPIKQEPMSEDMDKKDLMNGSDPSS 531
            .|.|..:......|....|......:|        ||.|.:.:...|.
Zfish   560 CSMGFLTESSLTEHIQQTHCSSVGGVTKMESPVLQPSQSFMEVYSCPY----------------- 607

  Fly   532 DTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNSVLSN 596
                       .:|:....||:|   |...::|:.|.              .|| :||...|...
Zfish   608 -----------CTNSPIFGSLLK---LTKHIKENHKN--------------IPL-ANNKRKVKVA 643

  Fly   597 SLSNGSGR---GSP---GVNGGSGGGGGGGPPTPATPSATNGASSTPICNGTITS-TGQDGDLLI 654
            .||..|..   .||   .|.|.|            ||:..||......|:...:| .|....|..
Zfish   644 DLSPASSDVEISSPKRHRVTGDS------------TPAVANGDYPCNQCDLRFSSFEGFQAHLKS 696

  Fly   655 NRKLIL---TCHFCGIE-FPDETLYFLHKGCH--CESNPWRCNICGEQLNNVYEFNSHLL 708
            :.:|:|   :|..|..| |..:.....|...|  ..|..:.|..|.:|.::|.:...|||
Zfish   697 HLELLLRRQSCPQCNKEDFDSQEALLQHLTIHYTTTSTQYVCESCDKQFSSVDDLQKHLL 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..255	CDD:275368	6/15 (40%)
		C2H2 Zn finger	662..689	CDD:275371	7/29 (24%)
		C2H2 Zn finger	690..712	CDD:275371	7/19 (37%)
si:ch211-216l23.1	XP_005159186.1	COG5048	<151..256	CDD:227381	34/104 (33%)
		C2H2 Zn finger	152..172	CDD:275368	3/19 (16%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	206..>539	CDD:227381	70/371 (19%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		C2H2 Zn finger	288..307	CDD:275368	0/18 (0%)
		C2H2 Zn finger	439..460	CDD:275368	4/20 (20%)
		C2H2 Zn finger	471..492	CDD:275368	6/36 (17%)
		C2H2 Zn finger	515..534	CDD:275368	5/27 (19%)
		C2H2 Zn finger	677..697	CDD:275368	4/19 (21%)
		C2H2 Zn finger	707..728	CDD:275368	5/20 (25%)
		C2H2 Zn finger	738..755	CDD:275368	4/16 (25%)
		C2H2 Zn finger	766..783	CDD:275368
		C2H2 Zn finger	796..817	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		C2H2 Zn finger	859..877	CDD:275368
		C2H2 Zn finger	956..977	CDD:275368
		C2H2 Zn finger	1002..1022	CDD:275368
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1288..1308	CDD:275368
		C2H2 Zn finger	1319..1340	CDD:275368
		C2H2 Zn finger	1349..1365	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930