DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and ZNF107

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	619	Identity:	123/619 - (19%)
Similarity:	189/619 - (30%)	Gaps:	187/619 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EPENMSL----GHME---GGKGDGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKF 190
            |.||:.|    .|::   |.||...|.|...::..|                 |:|:|:.....|
Human   151 EYENLQLRKGCKHVDECTGHKGGHNTVNQCLTATPS-----------------KIFQCNKYVKVF 198

  Fly   191 SNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAH 255
            ...:|..|:|.||||.|.::|:.|.|.|.....|.:|...||:...|.|..|.:.|.....:..|
Human   199 DKFSNSNRYKRRHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFSTLTKH 263

  Fly   256 FQNEHVGQHDLVKTCPLCSYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSLLLALESQASAAAAA 320
             :..|.|:...  .|..|.........|     .||.|......|........|.:.    |:..
Human   264 -KRIHTGEKPY--KCEECGKAFNQSSQL-----TRHKIIHTEEKPNKCEECGKAFKQ----ASHL 316

  Fly   321 AAASYVPPGLSPV------PVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMHF---LTPHVE 376
            .....:..|..|.      .|.|||.....|::.    .:||::...:......:.   ||.|..
Human   317 TIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKIL----HTGENLYKCKECGKAFNLFSNLTNHKR 377

  Fly   377 IST------LGESGNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCNSISNGNA 435
            |..      ..|.|..  ||:           ::|.|......|      .|..|.|...
Human   378 IHAGEKPYKCKECGRA--FNI-----------SSNLNKQEKIHT------GGKLNKCEEC----- 418

  Fly   436 ESNGDKVKDRAL--------IMQSPVELPMDCNTKATPITSSTTASSLSGGLKSHHQHPHHHHHH 492
                ||..:|:|        :|:   |.|..|..........:|.:               .|..
Human   419 ----DKAFNRSLKLTAHKKILME---EKPYKCEECGKVFNQFSTLT---------------RHKI 461

  Fly   493 HHHHENHITPSISLIPIKQEP------MSEDMDKKDLMNGSDPSSDTEQ---ASNNNNSSSNNNR 548
            .|..|.         |.|.:.      .|.::.:...::.::.|...|:   |.|.:::..|:.:
Human   462 IHTGEK---------PYKCKECGKAFNQSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRK 517

  Fly   549 ITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGS 613
            |.|..|  |.|.   |:     |.||.||             :|.|:......:|
Human   518 IYSGEK--PYKC---EE-----CGKAFNR-------------SSTLTRHKKIHTG---------- 549

  Fly   614 GGGGGGGPPTPATPSATNGASSTPI-CNGTITSTGQDGDLLINRKL-----ILTCHFCGIEFPDE 672
                                 ..|. |.....:..|..:|..::|:     ...|..||..|...
Human   550 ---------------------EKPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRF 593

  Fly   673 TLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSH 706
            :....||..|....|::|..||:..|..|:...|
Human   594 STLTKHKRIHTGEKPYKCEECGKAFNQSYQLTRH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	11/22 (50%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	3/15 (20%)
		C2H2 Zn finger	662..689	CDD:275371	8/26 (31%)
		C2H2 Zn finger	690..712	CDD:275371	6/17 (35%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	5/19 (26%)
		C2H2 Zn finger	219..239	CDD:275368	6/19 (32%)
		COG5048	243..621	CDD:227381	90/502 (18%)
		C2H2 Zn finger	247..267	CDD:275368	4/20 (20%)
		C2H2 Zn finger	275..295	CDD:275368	6/24 (25%)
		C2H2 Zn finger	303..323	CDD:275368	2/23 (9%)
		C2H2 Zn finger	331..351	CDD:275368	5/23 (22%)
		C2H2 Zn finger	359..379	CDD:275368	3/19 (16%)
		C2H2 Zn finger	387..407	CDD:275368	6/32 (19%)
		C2H2 Zn finger	415..435	CDD:275368	5/28 (18%)
		C2H2 Zn finger	443..463	CDD:275368	3/34 (9%)
		C2H2 Zn finger	471..491	CDD:275368	1/19 (5%)
		C2H2 Zn finger	499..519	CDD:275368	4/19 (21%)
		C2H2 Zn finger	527..547	CDD:275368	8/40 (20%)
		COG5048	551..>863	CDD:227381	19/77 (25%)
		C2H2 Zn finger	555..575	CDD:275368	4/19 (21%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		C2H2 Zn finger	611..631	CDD:275368	6/17 (35%)
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910