DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and Zfp462

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_038966959.1	Gene:	Zfp462 / 362522	RGDID:	1562123	Length:	2565	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	111/644 - (17%)
Similarity:	188/644 - (29%)	Gaps:	244/644 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LSTGPHSPPMTFRCERCDSFETSSRASLLLHV-----------------VQCLAGQAAAAAAAA- 120
            |.:||.....||:|:.||| :..|.|.|..|:                 .|.|:.|..|..|.|
  Rat  1879 LGSGPRFQNSTFQCKHCDS-KLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFAD 1942

  Fly   121 -----------------------------------------------------AASARLKSEDLQ 132
                                                                 |.||.:|.| .:
  Rat  1943 FKQERPFGHLEEAPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGSVPAVSAAVKQE-AE 2006

  Fly   133 EPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNSGGG--------------GGGNSSSRKVFEC 183
            :|.::.|...|..:           .||.:..|...||              ||        :.|
  Rat  2007 DPSHLFLDGFEAAR-----------DASGTLVGRVDGGHCLLDGMLEDETRPGG--------YHC 2052

  Fly   184 DVCNMKFSNGANMRRHKMRH------TGVKPYECRVCQKRFFRKDHLAEHFTT-HTKTLPYHCPI 241
            ..|:....:...:|.|:..|      |....|.|:.|......:.:|..|..| |....|:.|.:
  Rat  2053 SQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKL 2117

  Fly   242 CNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLCSYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSL 306
            |:........::.|....|.|:|  ...|..||:...::..|:.|....||..|..|.|...|
  Rat  2118 CSFKSSYNSRLKTHILKAHAGEH--AYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVS-- 2178

  Fly   307 LLALESQASAAAAAAA--------ASYVPPGLSPVPVQSQSQQQQQQQVA------PPASDSGES 357
            ||:..:..|:..|..|        :||    ..|..||.|....|...:|      .|...||.:
  Rat  2179 LLSSHAHHSSQKATPAEEVEDSNDSSY----SEPPDVQQQLNHYQSAALARNNSRVSPVPPSGTA 2239

  Fly   358 MRSLENATPPMH-----------------------------------------FLTPHVEI--ST 379
            ..:.:.|...:|                                         ..|.|||.  |.
  Rat  2240 AGTEQKAEAVLHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSA 2304

  Fly   380 LGESGNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCNSISNGNAESNGDKVKD 444
            :.|.|..:|...:|::.                 |....|                      :.|
  Rat  2305 VPEEGPKDLRCPLCLYH-----------------TKYKRN----------------------MID 2330

  Fly   445 RALIMQSPVELPMD-CNTKATPIT------------SSTTASSLSGGLKSHHQ-HP------HHH 489
            ..::.:....:|:: |.:|.:...            :.::..||...::.|:: .|      ::.
  Rat  2331 HIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNELRPYKCQLCYYE 2395

  Fly   490 HHH------HHHHENHITPSISLI-PIKQEPMSEDMDKKDLMNGSDPSSDTEQASNNNN 541
            ..|      |...|:.::.:..|: .:..:.:.:..:|.:..:..|...|.|.:|...:
  Rat  2396 TKHTEELDTHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESSSSDDEDKDDEMSSKTED 2454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	4/19 (21%)
		zf-H2C2_2	195..218	CDD:290200	7/28 (25%)
		C2H2 Zn finger	211..231	CDD:275368	5/20 (25%)
		C2H2 Zn finger	239..255	CDD:275368	2/15 (13%)
		C2H2 Zn finger	662..689	CDD:275371
		C2H2 Zn finger	690..712	CDD:275371
Zfp462	XP_038966959.1	C2H2 Zn finger	2052..2072	CDD:275368	4/19 (21%)
		zf-H2C2_5	2084..2108	CDD:404746	6/23 (26%)
		C2H2 Zn finger	2086..2106	CDD:275368	4/19 (21%)
		C2H2 Zn finger	2115..2136	CDD:275368	3/20 (15%)
		C2H2 Zn finger	2144..2165	CDD:275368	5/20 (25%)
		C2H2 Zn finger	2315..2335	CDD:275368	4/58 (7%)
		C2H2 Zn finger	2361..2381	CDD:275368	2/19 (11%)
		C2H2 Zn finger	2389..2410	CDD:275368	2/20 (10%)
		C2H2 Zn finger	2475..2495	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930