DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and ZNF445

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_852466.1	Gene:	ZNF445 / 353274	HGNCID:	21018	Length:	1031	Species:	Homo sapiens

Alignment Length:	884	Identity:	161/884 - (18%)
Similarity:	251/884 - (28%)	Gaps:	359/884 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AETISTAASGMELALKDPSPTVGGGIIVDMTPTTAALLHHNAMALRSLKDAASSASESELQEPRS 66
            |||:: .:||.      |:.:|..||                 .||      .|..:...|:.:.
Human   331 AETLA-VSSGC------PATSVSEGI-----------------GLR------ESFQQKSRQKDQC 365

  Fly    67 PTP-------TPTNLS--TGPHSPPMTFRCERCDSFETSSRASL-LLHVVQC-LAGQAAAAAAAA 120
            ..|       ..||.|  ||..|             |.|...|| |.||... ::|:..:.....
Human   366 ENPIQVRVKKEETNFSHRTGKDS-------------EVSGSNSLDLKHVTYLRVSGRKESLKHGC 417

  Fly   121 AASARLKSEDLQ-EPENMSLGHMEGG-----------KGDGQTGNGSSSSASSSPAGNSGGGGGG 173
            ....|:.|.... :.....|.||.||           ||:.:...|...|.||...........|
Human   418 GKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVG 482

  Fly   174 NSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYH 238
            .|     |:|..|...||:.:::..|:..||..|.::||||.|.|....:.|.|...||...||.
Human   483 VS-----FKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKPYK 542

  Fly   239 CPICNRGFQRQIAMRAHFQ-----------------------NEHVG------------------ 262
            |.:|.:.|:|..|.|.|.:                       :.|:|
Human   543 CDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSFH 607

  Fly   263 ------QHDLVKT------CPLC----SYRAGSMKSLRIH----FFN--------RHGIDLDNP- 298
                  :|..:.|      |..|    .:|:...:.:|:|    |:.        |...|...|
Human   608 CKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQ 672

  Fly   299 -GP-----------GGT--------------------------------SSLLLALESQASAAAA 319
             .|           |.|                                |:.::..:..|.....
Human   673 GAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKP 737

  Fly   320 AAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMH-FLTPHVEISTLGES 383
            ....|:....:..||..|.|:::..:     .|..|::.|:        | ||..|..:.|
Human   738 EGGPSFSQDTVFQVPQSSHSKEEPYK-----CSQCGKAFRN--------HSFLLIHQRVHT---- 785

  Fly   384 GNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCNSISNGNAESNGDKVKDRALI 448
                                                                   |:|
Human   786 -------------------------------------------------------GEK------- 788

  Fly   449 MQSPVELPMDCNT--KATPITSSTTASSLSGGLKSHHQHPHHHHHHHHHHENHITPSIS---LIP 508
                   |..|..  ||...:|:.          ..||..|.....:..||:..||::.   |..
Human   789 -------PYKCRECGKAFRWSSNL----------YRHQRIHSLQKQYDCHESEKTPNVEPKILTG 836

  Fly   509 IK----QEPMSEDMDKKDLMNGSDPSSDTEQASNN--------NNSSSNNNRITSLIKVSPLKSL 561
            .|    ||.......|:.|::.....|..::...|        |....|:.||.|..:....:..
Human   837 EKRFWCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWC 901

  Fly   562 LREDLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGGGGPPTPAT 626
            .:|.:.|...:....:.||.|....|                                 ||..::
Human   902 GKEFIGRHTLSSHQRKHTRAAQAERS---------------------------------PPARSS 933

  Fly   627 PSAT-------NGASSTPI------CNGTITSTGQDGDLLINRKLILTCH---FCGIEFPDETLY 675
            ...|       ..:...|:      |:.:...||.. |:.|.:|    ||   .||..|...:..
Human   934 SQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQ-DISIGKK----CHKCSICGKTFNKSSQL 993

  Fly   676 FLHKGCHCESNPWRCNICGEQLNNVYEFNSHLL--SKSH 712
            ..||..|....|::|:.||:    .:.::|:|.  .|:|
Human   994 ISHKRFHTRERPFKCSKCGK----TFRWSSNLARHMKNH 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..255	CDD:275368	6/15 (40%)
		C2H2 Zn finger	662..689	CDD:275371	9/29 (31%)
		C2H2 Zn finger	690..712	CDD:275371	6/23 (26%)
ZNF445	NP_852466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		SCAN	51..155	CDD:128708
		KRAB	234..292	CDD:214630
		C2H2 Zn finger	415..451	CDD:275368	7/35 (20%)
		COG5048	<457..643	CDD:227381	41/190 (22%)
		C2H2 Zn finger	460..479	CDD:275368	4/18 (22%)
		C2H2 Zn finger	487..507	CDD:275368	5/19 (26%)
		C2H2 Zn finger	515..535	CDD:275368	8/19 (42%)
		C2H2 Zn finger	543..563	CDD:275368	7/19 (37%)
		COG5048	595..1031	CDD:227381	88/572 (15%)
		C2H2 Zn finger	599..619	CDD:275368	1/19 (5%)
		C2H2 Zn finger	627..647	CDD:275368	4/19 (21%)
		C2H2 Zn finger	683..703	CDD:275368	2/19 (11%)
		C2H2 Zn finger	711..731	CDD:275368	1/19 (5%)
		C2H2 Zn finger	764..784	CDD:275368	7/27 (26%)
		C2H2 Zn finger	792..812	CDD:275368	6/29 (21%)
		C2H2 Zn finger	842..862	CDD:275368	4/19 (21%)
		C2H2 Zn finger	870..890	CDD:275368	4/19 (21%)
		C2H2 Zn finger	898..918	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..939		7/60 (12%)
		C2H2 Zn finger	953..972	CDD:275368	4/19 (21%)
		C2H2 Zn finger	980..1000	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1008..1028	CDD:275368	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930