DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and Zfp521

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_038952847.1	Gene:	Zfp521 / 307579	RGDID:	1307345	Length:	1321	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	168/793 - (21%)
Similarity:	257/793 - (32%)	Gaps:	219/793 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RSLKDAASSASESELQE------PRSPTPTPTNLSTGPHSPPMTFRCERC-DSFETSSRASLLLH 104
            ||||| .:...|.::::      .:.|...........||      |:.| ..||  |.:.:..|
  Rat    10 RSLKD-PNCKLEDKIEDGEAVDCKKRPDDGEELEEDAVHS------CDSCLQVFE--SLSDITEH 65

  Fly   105 VV-QC-------LAGQAAAAAAAAAASARLKSEDLQEP---ENMSLGHMEGGKG---DGQTGNGS 155
            .: ||       :......:..|::.|    |:|...|   |....|..|||.|   ..|..:.|
  Rat    66 KIHQCQLTDGVDVEDDPTCSWPASSPS----SKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKS 126

  Fly   156 SSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFR 220
            .|..|.......      :.|.:..|:|..|:..|.:..:..||...|||.|.|.|..|...|.|
  Rat   127 FSRLSYLKHHEQ------SHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSR 185

  Fly   221 KDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLVK----------------- 268
            .|||..|..|||...||.|.:|.|||....::..|.|     .|:..|
  Rat   186 SDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLHGHMQ-----VHERSKDGSQSGSRMEDWKMKDT 245

  Fly   269 -TCPLCSYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSLLLALESQASAAAAAAAASYVPPGLSP 332
             .|..|.......:.|:.|....|.                  |...:...||....|    ...
  Rat   246 QKCSQCEEGFDFPEDLQKHIAECHP------------------ECSPNEDRAALQCVY----CHE 288

  Fly   333 VPVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMHFLTPHVEISTLGESGNTELFNLICVWRE 397
            :.|:..|.....:||     ..||...|....:.  .|||  ||          ||::.:    :
  Rat   289 LFVEETSLMNHIEQV-----HGGEKKNSCSICSE--SFLT--VE----------ELYSHM----D 330

  Fly   398 SALQGNNNNNNNNN----------CATNNNNNINGASNNCNSISNGNAESNGDKVKDRALIMQSP 452
            |..|..:.|::|:.          .:|..::|::..|:.....:....:|.|.|   ||....|.
  Rat   331 SHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRK---RAAQQTSD 392

  Fly   453 VELPMDCNTKATPITSS---------TTASSLSGGLKSHH-QHPHHHH----------------- 490
            :..|   ::|...:|.|         ::.:.|...||:.| ..|...|
  Rat   393 MTGP---SSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNE 454

  Fly   491 HHHHHHE------------------NHITPSISLIPIKQE----------PMSEDMDK---KDLM 524
            |....||                  |..:..::.:...||          |.::|.:.   ....
  Rat   455 HLKQVHEAQDPGLIVSAMPAIIYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFFCPHCY 519

  Fly   525 NGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKA---NNRITRNATPLE 586
            .|....|..|:.....:...:.:|..|.:..:| |..:.|......|..:   |:.:..|....|
  Rat   520 MGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTP-KEPVVEVYSCSYCTNSPIFNSVLKLNKHIKE 583

  Fly   587 SNNNNSVLSNSLSNG--SGRGSP---------------GVNGGSGGGGGGGPPTPATPSATN--G 632
            ::.|..:..|.:.||  |...||               .|        ||||...|.....|  |
  Rat   584 NHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQTV--------GGGPARAAGEYICNQCG 640

  Fly   633 ASSTPICNGTITSTGQDGDLLINRKLILTCHFCGIEFPDETLYFLHKGCH--CESNPWRCNICGE 695
            |..|.: :...|......|.::.:   |||..|..|||::.....|...|  ..|..:.|..|.:
  Rat   641 AKYTSL-DSFQTHLKTHLDTVLPK---LTCPQCNKEFPNQESLLKHVTIHFMITSTYYICESCDK 701

  Fly   696 QLNNVYEFNSHLL 708
            |..:|.:...|||
  Rat   702 QFTSVDDLQKHLL 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..255	CDD:275368	5/15 (33%)
		C2H2 Zn finger	662..689	CDD:275371	8/28 (29%)
		C2H2 Zn finger	690..712	CDD:275371	7/19 (37%)
Zfp521	XP_038952847.1	COG5048	<84..236	CDD:227381	49/166 (30%)
		C2H2 Zn finger	120..140	CDD:275368	4/25 (16%)
		C2H2 Zn finger	148..168	CDD:275368	5/19 (26%)
		C2H2 Zn finger	176..196	CDD:275368	8/19 (42%)
		C2H2 Zn finger	204..224	CDD:275368	7/24 (29%)
		C2H2 Zn finger	312..332	CDD:275368	7/37 (19%)
		C2H2 Zn finger	407..428	CDD:275368	3/20 (15%)
		C2H2 Zn finger	439..460	CDD:275368	1/20 (5%)
		C2H2 Zn finger	479..498	CDD:275368	3/18 (17%)
		C2H2 Zn finger	636..656	CDD:275368	5/20 (25%)
		C2H2 Zn finger	666..686	CDD:275368	6/19 (32%)
		C2H2 Zn finger	696..713	CDD:275368	4/16 (25%)
		C2H2 Zn finger	724..745	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
		COG5236	785..>964	CDD:227561
		C2H2 Zn finger	785..805	CDD:275368
		C2H2 Zn finger	811..829	CDD:275368
		C2H2 Zn finger	888..909	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930