DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and Ikzf3

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001100517.1	Gene:	Ikzf3 / 303511	RGDID:	1307024	Length:	509	Species:	Rattus norvegicus

Alignment Length:	702	Identity:	143/702 - (20%)
Similarity:	226/702 - (32%)	Gaps:	234/702 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LKDAASSASESELQEPRSPTPTPTNLSTGPHSPPMTFRCERCDSFETSSRASLLLHVVQCLAGQA 113
            ::|...||.....:|...||.:|..|:  .:|.|.....|..|..|..:....       .||:.
  Rat     1 MEDIQPSAELKSTEEQPLPTESPEALN--DYSLPKPHEIENVDGTEAPANEDE-------DAGED 56

  Fly   114 AAAAAAAAASARLKSEDLQEPENMSLGHMEGGKGDGQTGNGSSSSA------------------S 160
            .........|.|  .|::.:||.|.         |.:......|.|                  |
  Rat    57 LMMKVKDEYSER--DENILKPEPMV---------DAEESEPPYSYAREYSDYENIKLERHGPYDS 110

  Fly   161 SSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLA 225
            |.|....             ..||||.:...:...:..||..|||.:|::|..|...|.:|.:|.
  Rat   111 SRPTSGK-------------MNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLL 162

  Fly   226 EHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLVK--TCPLC--SYRAGSMKSLRIH 286
            .|...||...|:.|.:||...||:.|:..|.:.     |.:.|  .|..|  ||:..|  ||..|
  Rat   163 RHIKLHTGEKPFKCHLCNYACQRRDALTGHLRT-----HSVEKPYKCEFCGRSYKQRS--SLEEH 220

  Fly   287 FFNRHGIDLDNPGPGGTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPA 351
             ..|....|.||..|..:|    :|::...|...:..:.|...|                    |
  Rat   221 -KERCRAFLQNPDLGDAAS----VEARHIKAEMGSERALVLDRL--------------------A 260

  Fly   352 SDSGESMRSLENATPPMHFLTPHVEISTLGESGNTELFNLICVWRESALQGNNN-----NNNNNN 411
            |:..:...|:     |..|         :||             :......|.|     ...|..
  Rat   261 SNVAKRKSSM-----PQKF---------IGE-------------KRHCFDANYNPGYMYEKENEM 298

  Fly   412 CATNNNNNINGASNNCNSISNGNAESNGDKVKDRALIMQSPVELPMDCNTKATPITSST-----T 471
            ..|   ..::.|.|  |:||...||:           ::..|:.|....::..|:.||.     |
  Rat   299 MQT---RMMDQAIN--NAISYLGAEA-----------LRPLVQTPPAPTSEMVPVISSVYPIALT 347

  Fly   472 ASSLSGGLKSHHQHPHHHHHHHHHHENHITPSISLIPIKQEPMSEDMDKKDLMNGSDPSSDTEQA 536
            .:.:..|.                 ...:.....|:|.|..|....:...   |.:..|:||:
  Rat   348 RADMPNGA-----------------PQELEKKRILLPEKILPSERGLSPN---NSAQDSTDTD-- 390

  Fly   537 SNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKANNRI--TRNATPL--ESNNNNSVLSNS 597
                   ||:                 ||.:..|..:.:..:  .||..||  |...:..:|.
  Rat   391 -------SNH-----------------EDRQNHIYQQGHMVLPQARNGMPLLKEVPRSFELLK-- 429

  Fly   598 LSNGSGRGSPGVNGGSGGGGGGGPPTPATPSATNGASSTPIC-NGTITSTGQDGDLLINRKLILT 661
                                   ||              ||| ..:|....::|:::.    :..
  Rat   430 -----------------------PP--------------PICLRDSIKVINKEGEVMD----VFR 453

  Fly   662 CHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSKSHQ 713
            |..|.:.|.|..::.:|.|||...:|:.||:||.:.::.|||:||:....|:
  Rat   454 CDHCHVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	6/19 (32%)
		zf-H2C2_2	195..218	CDD:290200	8/22 (36%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	6/15 (40%)
		C2H2 Zn finger	662..689	CDD:275371	9/26 (35%)
		C2H2 Zn finger	690..712	CDD:275371	9/21 (43%)
Ikzf3	NP_001100517.1	COG5048	<107..>219	CDD:227381	38/131 (29%)
		C2H2 Zn finger	120..140	CDD:275368	6/19 (32%)
		zf-H2C2_2	133..157	CDD:290200	9/23 (39%)
		C2H2 Zn finger	148..168	CDD:275368	6/19 (32%)
		zf-H2C2_2	160..183	CDD:290200	8/22 (36%)
		C2H2 Zn finger	176..196	CDD:275368	7/24 (29%)
		zf-H2C2_2	192..213	CDD:290200	7/25 (28%)
		C2H2 Zn finger	204..220	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4243
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960