DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12769 and Zfp445

DIOPT Version :9

Sequence 1:NP_001286181.1 Gene:CG12769 / 35770 FlyBaseID:FBgn0033252 Length:713 Species:Drosophila melanogaster
Sequence 2:NP_001178731.1 Gene:Zfp445 / 301076 RGDID:1559144 Length:977 Species:Rattus norvegicus


Alignment Length:857 Identity:149/857 - (17%)
Similarity:232/857 - (27%) Gaps:352/857 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LRSLKDAASSASESEL--------QEPRSPTPTPTNLSTGPHSPPMTFRCERCDSFETSSRASLL 102
            |:...|||....:.::        |||...|.|....|..|.|.....:    :|||..||    
  Rat   280 LKREPDAAPEGGKLQIEPSKFILKQEPSKYTETCVKPSGCPASKGTGLK----ESFEQKSR---- 336

  Fly   103 LHVVQCLAGQAA----------AAAAAAAASARLKSEDLQEPENMSLGHMEGGKGDGQTGNGSSS 157
               :|...|.:.          .:..|...|..|::.|:.|.:::....:...|...:.|...:.
  Rat   337 ---LQKSCGDSVQMKEMKKGTDISQKAGRKSEILRNSDILELKHVKCVSVSRKKLSFKHGYDRNF 398

  Fly   158 SASSSPAGNSGGGGGGNS--------------------------------------SSRKVFECD 184
            ..||....|..|.|..::                                      |...:|:|.
  Rat   399 RKSSHHYNNKYGEGLRDTVEGFGVYQNTGLKENEKDRCGETLRKSSHSHLEYQRYYSQGSLFKCR 463

  Fly   185 VCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFR----------------------------- 220
            ||...|...:|..||:..|||||||:|..|:|.|.|                             
  Rat   464 VCEKAFKWRSNCIRHEKIHTGVKPYKCSSCEKAFQRLSTYRLHQKTHTKQKHESRKYNNALPCSL 528

  Fly   221 --------------------------KDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQ-- 257
                                      :.:..||...||:..||:|..|.:.|:.:.....|.:  
  Rat   529 DVSHCLINQDEEKNFYCSQCGKHFSCRSYALEHQRIHTQEKPYNCIRCRKTFRWKSNFTRHMKLH 593

  Fly   258 --------------NEHVGQHDLVKT------CPLCSYRAGSMKSL----RIHFFNRHGIDLDNP 298
                          .::..|..::.|      |..|.......|||    |||            
  Rat   594 GKEVRNQERCQEDFKQNYSQSQVISTIEKTFLCQSCGKTFTQKKSLIEHQRIH------------ 646

  Fly   299 GPGGTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSLEN 363
                |...|  .:........|:.:||         :....|::...::.|   :||....|.:.
  Rat   647 ----TGEKL--YQCSGCGKTFASRSSY---------IIHMKQKRHAIKIKP---ESGSLPFSQDT 693

  Fly   364 ATPPMHFLTPHVEISTLGESGNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCN 428
            |     |..|                           |..:|....|.|            ..| 
  Rat   694 A-----FAIP---------------------------QSGHNTEEPNQC------------KYC- 713

  Fly   429 SISNGNAESN------GDKVKDRALIMQSPVELPMDCN--TKATPITSSTTASSLSGGLKSHHQH 485
                |.|..|      .:::..|        |.|..|.  .||....|:.          ..|:.
  Rat   714 ----GRAFHNRSFLLIHERIHTR--------EKPYKCRECEKAFRWRSNL----------YRHER 756

  Fly   486 PHHHHHHHHHHENHITPSI-SLIPIKQEPM------------SEDMDKKDLMNGSD--PSSDTEQ 535
            .|..|....:||:..|.:: |.|.|.::|.            ...:|.|.:.:|..  ..:..|:
  Rat   757 KHFLHKRRKYHESKETSNLQSKIFIDEKPFWCQECGKTFTRKRSLLDHKGIHSGERRFKCNLCEK 821

  Fly   536 ASNNNNSSSNNNRI------------------TSLIKVSPLK--------SLLREDLKRRICAKA 574
            :.:.|....|:.||                  |....|...|        ||..:......|...
  Rat   822 SFDRNYRLVNHQRIHTTEQPFQSQWHDKDFAGTHAHSVDQRKHRTLQSEYSLQSDKPGLSYCQDV 886

  Fly   575 NNRITR----NATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGGGGPPTPATPSATNGASS 635
            ...|..    ...||::.::.|.:|.:..|                    .||            
  Rat   887 RVNIQELELSGKKPLDNPSHESSMSTAFQN--------------------VPT------------ 919

  Fly   636 TPICNGTITSTGQDGDLLINRKLILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNV 700
                                :|....|..||..|...:....||.||.:..|::|.:||:.....
  Rat   920 --------------------KKACHKCSTCGKTFRKHSHLISHKRCHTKERPFKCIVCGKTFGWS 964

  Fly   701 YEFNSHLLSKSH 712
            .....|:  |||
  Rat   965 SNLTRHV--KSH 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12769NP_001286181.1 C2H2 Zn finger 183..203 CDD:275368 7/19 (37%)
zf-H2C2_2 195..218 CDD:290200 13/22 (59%)
C2H2 Zn finger 211..231 CDD:275368 7/74 (9%)
C2H2 Zn finger 239..255 CDD:275368 3/15 (20%)
C2H2 Zn finger 662..689 CDD:275371 9/26 (35%)
C2H2 Zn finger 690..712 CDD:275371 5/21 (24%)
Zfp445NP_001178731.1 SCAN 49..161 CDD:128708
SCAN 49..137 CDD:280241
KRAB 213..271 CDD:214630
KRAB 213..252 CDD:279668
C2H2 Zn finger 462..482 CDD:275368 7/19 (37%)
COG5048 <465..596 CDD:227381 27/130 (21%)
zf-H2C2_2 477..497 CDD:290200 12/19 (63%)
C2H2 Zn finger 490..510 CDD:275368 5/19 (26%)
COG5048 536..962 CDD:227381 93/574 (16%)
C2H2 Zn finger 545..565 CDD:275368 2/19 (11%)
C2H2 Zn finger 573..593 CDD:275368 4/19 (21%)
C2H2 Zn finger 626..646 CDD:275368 6/19 (32%)
zf-H2C2_2 638..663 CDD:290200 7/42 (17%)
C2H2 Zn finger 654..730 CDD:275368 19/136 (14%)
zf-H2C2_2 723..745 CDD:290200 5/29 (17%)
C2H2 Zn finger 738..758 CDD:275368 5/29 (17%)
C2H2 Zn finger 788..808 CDD:275368 2/19 (11%)
C2H2 Zn finger 816..836 CDD:275368 4/19 (21%)
C2H2 Zn finger 844..864 CDD:275370 2/19 (11%)
C2H2 Zn finger 926..946 CDD:275368 6/19 (32%)
zf-H2C2_2 938..961 CDD:290200 8/22 (36%)
C2H2 Zn finger 954..974 CDD:275368 5/21 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345879
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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