DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12769 and ZNF521

DIOPT Version :9

Sequence 1:NP_001286181.1 Gene:CG12769 / 35770 FlyBaseID:FBgn0033252 Length:713 Species:Drosophila melanogaster
Sequence 2:NP_056276.1 Gene:ZNF521 / 25925 HGNCID:24605 Length:1311 Species:Homo sapiens


Alignment Length:751 Identity:158/751 - (21%)
Similarity:240/751 - (31%) Gaps:217/751 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 CDS----FETSSRASLLLHVV-QC-------LAGQAAAAAAAAAASARLKSEDLQEP---ENMSL 139
            |||    ||  |.:.:..|.: ||       :......:..|::.|    |:|...|   |....
Human    49 CDSCLQVFE--SLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPS----SKDQTSPSHGEGCDF 107

  Fly   140 GHMEGGKG---DGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKM 201
            |..|||.|   ..|..:.|.|..|.......      :.|.:..|:|..|:..|.:..:..||..
Human   108 GEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQ------SHSDKLPFKCTYCSRLFKHKRSRDRHIK 166

  Fly   202 RHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQ----NEHVG 262
            .|||.|.|.|..|...|.|.|||..|..|||...||.|.||.|||....::..|.|    |:...
Human   167 LHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGS 231

  Fly   263 Q----------HDLVKTCPLCSYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSLLLALESQASAA 317
            |          .|..| |..|.......:.|:.|....|.                  |...:..
Human   232 QSGSRMEDWKMKDTQK-CSQCEEGFDFPEDLQKHIAECHP------------------ECSPNED 277

  Fly   318 AAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMHF---LTPHVEIST 379
            .||....|    ...:.|:..|.....:||     .|||...|....:...|.   |..|::...
Human   278 RAALQCVY----CHELFVEETSLMNHMEQV-----HSGEKKNSCSICSESFHTVEELYSHMDSHQ 333

  Fly   380 LGESGNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCN-SISNGN--------A 435
            ..||         |           |::|:.:..|....:::..:.:.| |:.:..        .
Human   334 QPES---------C-----------NHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIP 378

  Fly   436 ESNGDKVKDRALIMQSPVELPMDCNTKATPITSS---------TTASSLSGGLKSHH-QHPHHHH 490
            :|.|.|   ||......:..|   ::|...:|.|         ::.:.|...||:.| ..|...|
Human   379 KSRGRK---RAAQQTPDMTGP---SSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAH 437

  Fly   491 -----------------HHHHHHE------------------NHITPSISLIPIKQE-------- 512
                             |....||                  |..:..::.:...||        
Human   438 ICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGF 502

  Fly   513 --PMSEDMDK---KDLMNGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICA 572
              |.::|.:.   .....|....|..|:.....:...:.:|..|.:..:| |..:.|......|.
Human   503 ANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTP-KEPVVEVYSCSYCT 566

  Fly   573 KA---NNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGGGGPPTPATP------- 627
            .:   |:.:..|....|::.|..:..|.:.|  |:.|..:             :|.:|       
Human   567 NSPIFNSVLKLNKHIKENHKNIPLALNYIHN--GKKSRAL-------------SPLSPVAIEQTS 616

  Fly   628 ----SATNGASSTP----ICNGT-ITSTGQDG---------DLLINRKLILTCHFCGIEFPDETL 674
                .|..||.:.|    |||.. ...|..|.         |.::.:   |||..|..|||::..
Human   617 LKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPK---LTCPQCNKEFPNQES 678

  Fly   675 YFLHKGCH--CESNPWRCNICGEQLNNVYEFNSHLL 708
            ...|...|  ..|..:.|..|.:|..:|.:...|||
Human   679 LLKHVTIHFMITSTYYICESCDKQFTSVDDLQKHLL 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12769NP_001286181.1 C2H2 Zn finger 183..203 CDD:275368 5/19 (26%)
zf-H2C2_2 195..218 CDD:290200 9/22 (41%)
C2H2 Zn finger 211..231 CDD:275368 8/19 (42%)
C2H2 Zn finger 239..255 CDD:275368 6/15 (40%)
C2H2 Zn finger 662..689 CDD:275371 8/28 (29%)
C2H2 Zn finger 690..712 CDD:275371 7/19 (37%)
ZNF521NP_056276.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..108 6/30 (20%)
C2H2 Zn finger 120..140 CDD:275368 4/25 (16%)
COG5048 128..>216 CDD:227381 33/93 (35%)
C2H2 Zn finger 148..168 CDD:275368 5/19 (26%)
C2H2 Zn finger 176..196 CDD:275368 8/19 (42%)
C2H2 Zn finger 204..224 CDD:275368 8/19 (42%)
C2H2 Zn finger 248..265 CDD:275368 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..397 8/53 (15%)
C2H2 Zn finger 407..428 CDD:275368 3/20 (15%)
C2H2 Zn finger 439..460 CDD:275368 1/20 (5%)
C2H2 Zn finger 479..498 CDD:275368 3/18 (17%)
C2H2 Zn finger 636..656 CDD:275368 4/19 (21%)
C2H2 Zn finger 666..686 CDD:275368 6/19 (32%)
C2H2 Zn finger 696..713 CDD:275368 4/16 (25%)
C2H2 Zn finger 724..745 CDD:275368
C2H2 Zn finger 754..774 CDD:275368
C2H2 Zn finger 785..805 CDD:275368
C2H2 Zn finger 811..829 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..882
C2H2 Zn finger 888..909 CDD:275368
C2H2 Zn finger 932..952 CDD:275368
C2H2 Zn finger 961..981 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1188
C2H2 Zn finger 1227..1247 CDD:275368
C2H2 Zn finger 1258..1279 CDD:275368
C2H2 Zn finger 1288..1307 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152366
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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