DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and Zfp462

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_006537978.1	Gene:	Zfp462 / 242466	MGIID:	107690	Length:	2556	Species:	Mus musculus

Alignment Length:	402	Identity:	83/402 - (20%)
Similarity:	124/402 - (30%)	Gaps:	135/402 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LSTGPHSPPMTFRCERCDSFETSSRASLLLHV-----------------VQCLAGQAAAAAAAA- 120
            |.:||.....||:|:.||| :..|.|.|..|:                 .|.|:.|..|..|.|
Mouse  1870 LGSGPRFQNSTFQCKHCDS-KLQSIAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFAD 1933

  Fly   121 -----------------------------------------------------AASARLKSEDLQ 132
                                                                 |.||.:|.| .:
Mouse  1934 FKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGSVPAVSAAVKQE-AE 1997

  Fly   133 EPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNSGGG--------------GGGNSSSRKVFEC 183
            :|.::.|..:|..:           .||.:..|...||              ||        :.|
Mouse  1998 DPSHLFLDGLEAAR-----------DASGTLVGRVDGGHCLLDAMLEDETRPGG--------YHC 2043

  Fly   184 DVCNMKFSNGANMRRHKMRH------TGVKPYECRVCQKRFFRKDHLAEHFTT-HTKTLPYHCPI 241
            ..|:....:...:|.|:..|      |....|.|:.|......:.:|..|..| |....|:.|.:
Mouse  2044 SQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKL 2108

  Fly   242 CNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLCSYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSL 306
            |:........::.|....|.|:|  ...|..||:...::..|:.|....||..|..|.|...|
Mouse  2109 CSFKSSYNSRLKTHILKAHAGEH--AYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVS-- 2169

  Fly   307 LLALESQASAAAAAAA--------ASYVPPGLSPVPVQSQSQQQQQQQVA------PPASDSGES 357
            ||:..:..|:..|..|        :||    ..|..||.|....|...:|      .|...||.:
Mouse  2170 LLSSHAHPSSQKATPAEEVEDSNDSSY----SEPPDVQQQLNHYQSAALARNKSRVSPVPPSGTA 2230

  Fly   358 MRSLENATPPMH 369
            ..:.:.|...:|
Mouse  2231 AGTEQKAEAVLH 2242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	4/19 (21%)
		zf-H2C2_2	195..218	CDD:290200	7/28 (25%)
		C2H2 Zn finger	211..231	CDD:275368	5/20 (25%)
		C2H2 Zn finger	239..255	CDD:275368	2/15 (13%)
		C2H2 Zn finger	662..689	CDD:275371
		C2H2 Zn finger	690..712	CDD:275371
Zfp462	XP_006537978.1	C2H2 Zn finger	2043..2063	CDD:275368	4/19 (21%)
		zf-H2C2_5	2075..2099	CDD:404746	6/23 (26%)
		C2H2 Zn finger	2077..2097	CDD:275368	4/19 (21%)
		C2H2 Zn finger	2106..2127	CDD:275368	3/20 (15%)
		C2H2 Zn finger	2135..2156	CDD:275368	5/20 (25%)
		C2H2 Zn finger	2306..2326	CDD:275368
		C2H2 Zn finger	2352..2372	CDD:275368
		C2H2 Zn finger	2380..2401	CDD:275368
		C2H2 Zn finger	2466..2486	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842431
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930