DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and IKZF2

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_011509104.1	Gene:	IKZF2 / 22807	HGNCID:	13177	Length:	533	Species:	Homo sapiens

Alignment Length:	679	Identity:	143/679 - (21%)
Similarity:	230/679 - (33%)	Gaps:	202/679 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 MTFRCERCDSFETS---------SRASLLLHVVQCLA-GQ-AAAAAAAAAASARLKSEDLQEPEN 136
            :|...|..|.:.||         ..:::.:.:..... || |:.:...:..|.:|:.:..:|.:.
Human     5 LTMETEAIDGYITSGDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDR 69

  Fly   137 MSL-------GHMEGGKGDGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGA 194
            ..|       ||.||...: :....||..|.:.......|.||....:.|: :||||.|......
Human    70 KPLSREDEIRGHDEGSSLE-EPLIESSEVADNRKVQELQGEGGIRLPNGKL-KCDVCGMVCIGPN 132

  Fly   195 NMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNE 259
            .:..||..|||.:|:.|..|...|.:|.:|..|...|:...|:.||.|:...:|:.|:..|.:..
Human   133 VLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTH 197

  Fly   260 HVGQ-HDLVKTCPLC--SYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSLLLALESQASAAAAAA 321
            .||: |    .|..|  ||:..|  ||..|....|..                |::.:..||...
Human   198 SVGKPH----KCNYCGRSYKQRS--SLEEHKERCHNY----------------LQNVSMEAAGQV 240

  Fly   322 AASYVPP-------------GLSPVP------VQSQSQQQQQQQVAPPASDSGESMRSLENATPP 367
            .:.:|||             .:|.||      ::..:....:::.:.|....||.:
Human   241 MSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKL--------- 296

  Fly   368 MHFLTPHVEISTLGESGNTELFNLICVWRESA--LQGNNNNNNNNNCATNNNNNINGASNNCNSI 430
            |.|..|.:.            |::...:.:.|  :|.:..:...||..|     ..||
Human   297 MRFSYPDIH------------FDMNLTYEKEAELMQSHMMDQAINNAIT-----YLGA------- 337

  Fly   431 SNGNAESNGDKVKDRAL--IMQSPVELPMDCNTKATPITSSTTASSLSGGLKSHHQHPHH----- 488
                          .||  :||.|            |.|.:..|..:|... |...||:.
Human   338 --------------EALHPLMQHP------------PSTIAEVAPVISSAY-SQVYHPNRIERPI 375

  Fly   489 HHHHHHHHENHITPSISLIPIKQEPMSEDMDKKDLMNGSDPSSDTEQASNNNNSSSNNNRITSLI 553
            .......|||::...||||..|..|...:....   |....|:|:|.:.:::.|...:..:....
Human   376 SRETADSHENNMDGPISLIRPKSRPQEREASPS---NSCLDSTDSESSHDDHQSYQGHPALNPKR 437

  Fly   554 KVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGG 618
            |.||  :.::||:|.....||                        ..||.:....|..|.|
Human   438 KQSP--AYMKEDVKALDTTKA------------------------PKGSLKDIYKVFNGEG---- 472

  Fly   619 GGPPTPATPSATNGASSTPICNGTITSTGQDGDLLINRKLILTCHFCGIEFPDETLYFLHKGCHC 683
                                                .:.....|..|.:.|.|..:|.:|.|||.
Human   473 ------------------------------------EQIRAFKCEHCRVLFLDHVMYTIHMGCHG 501

  Fly   684 ESNPWRCNICGEQLNNVYEFNSHLLSKSH 712
            ..:|..|||||.:..:.|||:||::...|
Human   502 YRDPLECNICGYRSQDRYEFSSHIVRGEH 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		zf-H2C2_2	195..218	CDD:290200	8/22 (36%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	5/15 (33%)
		C2H2 Zn finger	662..689	CDD:275371	10/26 (38%)
		C2H2 Zn finger	690..712	CDD:275371	10/21 (48%)
IKZF2	XP_011509104.1	C2H2 Zn finger	121..141	CDD:275368	7/19 (37%)
		zf-H2C2_2	134..158	CDD:290200	9/23 (39%)
		COG5048	145..>214	CDD:227381	22/72 (31%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	161..186	CDD:290200	7/24 (29%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		C2H2 Zn finger	205..226	CDD:275368	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4359
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960