Protein Alignment CG12769 and Ikzf4

DIOPT Version :10

• Sequence 1: NP_001286181.1
• Gene: CG12769 / 35770
• FlyBaseID: FBgn0033252
• Length: 713
• Species: Drosophila melanogaster
• Sequence 2: NP_035902.2
• Gene: Ikzf4 / 22781
• MGIID: 1343139
• Length: 586
• Species: Mus musculus
• Alignment Length: 758
• Identity: 152/758 - (20%)
• Similarity: 235/758 - (31%)
• Gaps: 274/758 - (36%)

  Fly    23 VGGGIIVDMTPTTAALLHHNAMALRSLKDAASSASESELQEPRSPTPTPTNLST--GPHSPP--- 82
            :.||...|..|...   ..|...:.||  ...|:.:|.|::.....|...::||  ..||.|
Mouse    34 LSGGCAPDFLPQAQ---DSNHFIMESL--FCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRS 93

  Fly    83 MTFRCERCDSFETSSRASLLLHVVQCLAGQAAAAAAAAAASARLKSED--------LQEPENMSL 139
            ::....:.:.:.....:.||                  ....||..:|        |.||    |
Mouse    94 LSANSIKVEMYSDEESSRLL------------------GPDERLLDKDDSVIVEDSLSEP----L 136

  Fly   140 GHMEGGKGDGQTGNGSSSSASSSPAGNSGGG---GGGNSSSRKVFECDVCNMKFSNGANMRRHKM 201
            |:.:|                |.|..:|.||   ..|.      .:||||.|.......:..||.
Mouse   137 GYCDG----------------SGPEPHSPGGIRLPNGK------LKCDVCGMVCIGPNVLMVHKR 179

  Fly   202 RHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDL 266
            .|||.:|:.|..|...|.:|.:|..|...|:...|:.||.||...:|:.|:..|.:...|....:
Mouse   180 SHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTV 244

  Fly   267 VK--TCPLCSYRAGSMKSLRIHFFNRHGIDLDNPGPGGTSSLLLALESQASAAAAAAAASYVPPG 329
            .|  .|..|........:|..|....|             :.|.:|.:.|.|
Mouse   245 GKPYKCNYCGRSYKQQSTLEEHKERCH-------------NYLQSLSTDAQA------------- 283

  Fly   330 LSPVPVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMHFLTPHVEISTLGESGNTELFNLICV 394
            |:..|                    |:.:|.||..  |...|.|..|..|..:    .|.|.:..
Mouse   284 LTGQP--------------------GDEIRDLEMV--PDSMLHPSTERPTFID----RLANSLTK 322

  Fly   395 WRESALQGNNNNNNNNNCATNNNNNINGASNNCNSISN--GNAESNGDKVKDRALIMQ------- 450
            .:.|..|                 ...|......|:|:  .:..::|...||..|:..
Mouse   323 RKRSTPQ-----------------KFVGEKQMRFSLSDLPYDVNASGGYEKDVELVAHHGLEPGF 370

  Fly   451 ------------SPVEL-PMDCNTKATPITSSTTASSLSGGLKSHHQHPHHHHHHHHHHENHITP 502
                        .|:.| |.:|.::.||:.||                              :..
Mouse   371 GGSLAFVGTEHLRPLRLPPTNCISELTPVISS------------------------------VYT 405

  Fly   503 SISLIPIKQE-PMSEDMDK--KDLMNGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLRE 564
            .:..||.:.| |.|.:..:  :||.:|                             .||....|.
Mouse   406 QMQPIPSRLELPGSREAGEGPEDLGDG-----------------------------GPLLYRARG 441

  Fly   565 DLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGGG------GPPT 623
            .|.....:.:|.  .:::|..|||:.:.:                        ||      |||.
Mouse   442 SLTDPGASPSNG--CQDSTDTESNHEDRI------------------------GGVVSLPQGPPP 480

  Fly   624 PATPSATNG------ASSTP-----ICNGT-------ITSTGQDGDLLINRKLILTCHFCGIEFP 670
            ...|:...|      |...|     :..||       :...|:.|:.:...|    |..|.|.|.
Mouse   481 QPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFK----CEHCRILFL 541

  Fly   671 DETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSKSHQ 713
            |..::.:|.|||...:|:.|||||....:.|||:||::...|:
Mouse   542 DHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHK 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		zf-H2C2_2	195..218	CDD:463886	8/22 (36%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	6/15 (40%)
		C2H2 Zn finger	662..689	CDD:275371	10/26 (38%)
		C2H2 Zn finger	690..712	CDD:275371	10/21 (48%)
Ikzf4	NP_035902.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..98		6/29 (21%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	174..198	CDD:463886	9/23 (39%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..226	CDD:463886	8/24 (33%)
		SFP1	<211..271	CDD:227516	14/59 (24%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..271	CDD:275368	4/20 (20%)
		Interaction with FOXP3. /evidence=ECO:0000269|PubMed:19696312	281..586		84/449 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..490		21/131 (16%)
		CTBP-binding motif PEDLG	423..433		3/38 (8%)