DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and sdz-12

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_494634.1	Gene:	sdz-12 / 184388	WormBaseID:	WBGene00017406	Length:	330	Species:	Caenorhabditis elegans

Alignment Length:	227	Identity:	64/227 - (28%)
Similarity:	97/227 - (42%)	Gaps:	22/227 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 GGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTL 235
            |..|..:.| |.|:.|..:|:|..|::||::.|:|.|..:|..||:.|||:|.|..|...|.|..
Worm    54 GRSNVVNHK-FRCENCEKQFTNKPNLKRHQITHSGSKSKKCSTCQRTFFREDQLQRHLHNHLKER 117

  Fly   236 P-YHCPI--CNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLCSYRAGSMKSLRIHFFNRHGIDLDN 297
            . :.||:  |:..|.....:..|..|.|...:.....|..|....||.:.|.:|:...|...|.:
Worm   118 SHFDCPVLNCSMQFVFYEGVENHLVNHHHFSYSESAPCGKCHKLFGSPRHLLVHYHFDHKEALRS 182

  Fly   298 PGPGGTSSLLLA----LESQASAAAAAAAASYVPP-------GLSPVPVQSQSQQQQ------QQ 345
            ..|..|||..|:    ..|.:..|..|.:....||       |.||: ::...:|..      .|
Worm   183 SAPAPTSSARLSPITVSTSGSPRAQLAISPQEKPPQKLSINLGTSPM-IEEFCEQNSATLPNTDQ 246

  Fly   346 QVAPPASDSGESMRSLENATPPMHFLTPHVEI 377
            |::|..|.:....|:|..:.|...|...|..|
Worm   247 QLSPTLSPNEPRFRNLITSEPTPSFECKHCTI 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		zf-H2C2_2	195..218	CDD:290200	9/22 (41%)
		C2H2 Zn finger	211..231	CDD:275368	9/19 (47%)
		C2H2 Zn finger	239..255	CDD:275368	4/17 (24%)
		C2H2 Zn finger	662..689	CDD:275371
		C2H2 Zn finger	690..712	CDD:275371
sdz-12	NP_494634.1	SFP1	<25..86	CDD:227516	11/32 (34%)
		C2H2 Zn finger	29..48	CDD:275368
		COG5236	<32..>197	CDD:227561	45/143 (31%)
		C2H2 Zn finger	65..85	CDD:275368	7/19 (37%)
		C2H2 Zn finger	93..113	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKBX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24404
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.800