Protein Alignment CG12769 and hbl-1

DIOPT Version :10

• Sequence 1: NP_001286181.1
• Gene: CG12769 / 35770
• FlyBaseID: FBgn0033252
• Length: 713
• Species: Drosophila melanogaster
• Sequence 2: NP_001041243.1
• Gene: hbl-1 / 180848
• WormBaseID: WBGene00001824
• Length: 982
• Species: Caenorhabditis elegans
• Alignment Length: 755
• Identity: 152/755 - (20%)
• Similarity: 244/755 - (32%)
• Gaps: 222/755 - (29%)

  Fly     7 TAASGMELAL-KDPSPTVGGGIIVDMTPTTAALLHHNAMALRSLKDAASSASESELQEPRSP--- 67
            :|:|...|:| ||.|.|.....|.:::.|.|::|.       |..:|.||.|.:|.....|.
 Worm   402 SASSPKNLSLSKDGSATSPINEIFNLSTTMASILD-------STNNAVSSTSTTEQPSALSALTL 459

  Fly    68 --TPTPTNLSTGPHSPPMTFRCERCDSFETSSRASLLLHVVQCLAGQAAAAAAAAAASARLKSED 130
              :.||:.|||..||   :|.....|..:..|.....:.     .|....|:|....|..:|. |
 Worm   460 DMSSTPSLLSTLAHS---SFGVSALDQIKAISENPSFMP-----EGGINLASALGVVSNAIKG-D 515

  Fly   131 LQEPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGAN 195
            ...||..|              ||....:||...              |:|:|..|..:..:..:
 Worm   516 TPSPEKQS--------------NGECRRSSSGKI--------------KIFKCKQCGHQSLSKDD 552

  Fly   196 MRRHKMRH-TGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNE 259
            ...|...| ...|...|:.|......|.||..|:..|..:.|:.|..|......:..:.:|.::
 Worm   553 QWAHARTHIPAEKQLNCQHCNFVTEYKHHLEYHYRNHIGSKPFQCKKCAYNCVNKSMLNSHMKS- 616

  Fly   260 HVGQHDLVKTCPLCSYRAGSMKSLRIHF--FNR----HGIDLDNPGPGGTSSLLLALESQASAAA 318
            |...:..  .|..|:|......||::|.  :|.    .||::.    ||.||
 Worm   617 HTNHYQF--RCMDCTYATKYCHSLKLHLKKYNHRRVPEGIEMS----GGDSS------------- 662

  Fly   319 AAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSLENATPPMHFLTPHVEISTLGES 383
                    ||..|...:......:|:.:.        |::..:.:...|..|
 Worm   663 --------PPFTSDATITFSPLMKQEIKT--------ETVEPVTSIAQPFPF------------- 698

  Fly   384 GNTELFNLICVWRESALQGNNNNNNNNNCATNNNNNIN--GASNN---------CNSISNGNAES 437
                          :.:.||:..|..|:...|.:.::.  |..|:         |:.:    |.|
 Worm   699 --------------NPMMGNHGLNFANHMLLNKHLDVGLMGLRNSVMSPLKCSACDFV----ASS 745

  Fly   438 NGDKVKDRALIMQSPVELPMDCNTKATPITSSTTASSLSGGLKSHHQHPHHHHHHHHHHENHITP 502
            ..:|::.....:.:...:|             |:.:||...|.                    .|
 Worm   746 ADEKMRHSMSHILNSSNVP-------------TSIASLYNSLN--------------------LP 777

  Fly   503 SISLIPIKQEPMSEDMD-----KKDLMNGSDPSSDTEQASNNNNSSSNNNRITS-LIKVSPLKSL 561
            |.|.:....:...|.||     ..|.:..|....:.:|.|::..|.:.:::|:| ..:....|||
 Worm   778 SFSHVAPDNDNALESMDCDVKIDDDNITESHCYEEMDQGSDSAVSPTGSSQISSGDEETKKCKSL 842

  Fly   562 LREDLKRRICAKANNRITRNATPLESNNNNSVLSNSLSNGSGRGSPGVNGGSGGGGGGGPPTPAT 626
            ..|.:..|                 :|.|||.:||             :......|......|.:
 Worm   843 SLEQISAR-----------------ANGNNSPMSN-------------DSAMEKDGESADDAPHS 877

  Fly   627 PSATNGASSTPICNGTITS----TGQD--------------GDLLINRKLILTCHFCGIEFPDET 673
            ||.|....|.|:.:.:|.:    |.|.              |.||.||.....|..|.|.|..:.
 Worm   878 PSDTTSVPSPPLHSSSIVAPIPITPQPNEFLQSILAQASLLGPLLANRPSAFYCDHCKIPFDTQQ 942

  Fly   674 LYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSKSHQ 713
            :...|...|...||:.|:.|..|..|...|..|:....||
 Worm   943 VLDSHMRFHTPGNPFMCSDCQYQAFNELSFALHMYQARHQ 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	3/19 (16%)
		zf-H2C2_2	195..218	CDD:463886	5/23 (22%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	2/15 (13%)
		C2H2 Zn finger	662..689	CDD:275371	8/26 (31%)
		C2H2 Zn finger	690..712	CDD:275371	6/21 (29%)
hbl-1	NP_001041243.1	DUF4045	<94..221	CDD:433066
		C2H2 Zn finger	338..361	CDD:275371
		C2H2 Zn finger	363..384	CDD:275371
		C2H2 Zn finger	569..589	CDD:275368	6/19 (32%)
		C2H2 Zn finger	597..617	CDD:275368	3/20 (15%)
		zf-H2C2_2	609..634	CDD:463886	5/27 (19%)
		C2H2 Zn finger	625..643	CDD:275368	6/17 (35%)
		C2H2 Zn finger	931..951	CDD:275368	5/19 (26%)
		C2H2 Zn finger	959..982	CDD:275368	6/22 (27%)