DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and ZNF786

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_689624.2	Gene:	ZNF786 / 136051	HGNCID:	21806	Length:	782	Species:	Homo sapiens

Alignment Length:	212	Identity:	52/212 - (24%)
Similarity:	80/212 - (37%)	Gaps:	48/212 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 HSPPMTFRCERCDSFETSSRASLLLHVVQCLAGQAAAAAAAAAASARLKSEDLQEPENMSLGHME 143
            ||....|.|..|....|  |.|.|...::..:|:..........|.|||.:        .|.|..
Human   559 HSKERPFSCGECGKGFT--RQSKLTEHLRVHSGERPFQCPECNRSFRLKGQ--------LLSHQR 613

  Fly   144 GGKGDGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKP 208
            ...|:                              :.|:|..|:.::...|:|:.|::.|:|..|
Human   614 LHTGE------------------------------RPFQCPECDKRYRVKADMKAHQLLHSGEMP 648

  Fly   209 YECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLVKTCPLC 273
            :.|. |.|.|.:...|.||..|||...|:.||.|::.|:.:..:.:| |..|.|:...  .||.|
Human   649 FSCE-CGKGFVKHSKLIEHIRTHTGEKPFQCPKCDKSFRLKAQLLSH-QGLHTGERPF--HCPEC 709

  Fly   274 S----YRAGSMKSLRIH 286
            .    .|...::..|||
Human   710 DKNFRERGHMLRHQRIH 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	8/22 (36%)
		C2H2 Zn finger	211..231	CDD:275368	7/19 (37%)
		C2H2 Zn finger	239..255	CDD:275368	4/15 (27%)
		C2H2 Zn finger	662..689	CDD:275371
		C2H2 Zn finger	690..712	CDD:275371
ZNF786	NP_689624.2	KRAB	9..67	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..164
		C2H2 Zn finger	242..262	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..364
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		COG5048	<471..722	CDD:227381	49/206 (24%)
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		C2H2 Zn finger	539..559	CDD:275368	52/212 (25%)
		C2H2 Zn finger	567..587	CDD:275368	6/21 (29%)
		C2H2 Zn finger	595..615	CDD:275368	6/27 (22%)
		C2H2 Zn finger	623..643	CDD:275368	5/19 (26%)
		C2H2 Zn finger	652..670	CDD:275368	6/18 (33%)
		C2H2 Zn finger	678..698	CDD:275368	6/20 (30%)
		C2H2 Zn finger	706..726	CDD:275368	5/19 (26%)
		C2H2 Zn finger	734..754	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930