Protein Alignment CG12769 and hb

DIOPT Version :10

• Sequence 1: NP_001286181.1
• Gene: CG12769 / 35770
• FlyBaseID: FBgn0033252
• Length: 713
• Species: Drosophila melanogaster
• Sequence 2: XP_061510668.1
• Gene: hb / 1278884
• VectorBaseID: AGAMI1_001557
• Length: 723
• Species: Anopheles gambiae
• Alignment Length: 745
• Identity: 154/745 - (20%)
• Similarity: 234/745 - (31%)
• Gaps: 253/745 - (33%)

  Fly    52 AASSASESELQEPRSPTPT------------PTNLSTGPHSPPMTFRCERC--DSFETSSRASLL 102
            ||....:.:..:.|..||.            ||:| |..|:|||.....:.  :|.||.:
Mosquito   148 AAQQQQQHQQHQQRLATPNRMYGNGTGKVELPTSL-TPTHTPPMDVTPPKSPKESLETPT----- 206

  Fly   103 LHVVQCLAGQAAAAAAAAAASARLKSEDLQEPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNS 167
                                    |.||       :....|.|..||    .........|..||
Mosquito   207 ------------------------KEED-------AGSDCEDGSYDG----SEDEDGIRKPKVNS 236

  Fly   168 GGGGGGNSSSRKVFECDVCNMKFSNGANMRRHKMRHTGVKPYECRVCQKRFF---RKDHLAEHFT 229
            .|       ..|.|.|..|........:...|...|  :||.:...|.|..|   .|.||..|..
Mosquito   237 HG-------QVKKFRCKQCEFVAVTKLSFWEHTRSH--IKPEKMLTCPKCPFVTEYKHHLEYHLR 292

  Fly   230 THTKTLPYHCPICNRGFQRQIAMRAHFQNEHVGQHDLV--KTCPLCSYRAGSMKSLRIHFFNRHG 292
            .|.::.|:.||.|:..     .:.....|.|:..|..|  ..|..|:|......||::| ..::.
Mosquito   293 NHQRSKPFQCPKCSYS-----CVNKSMLNSHMKSHSNVFQYRCADCNYATKYCHSLKLH-LRKYA 351

  Fly   293 ------IDLDNPGPGGTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQQQQQVAP-- 349
                  ::||     ||.:.|..::...:.....|.    |...:...:..|.|.||:||..|
Mosquito   352 HKPDVVLNLD-----GTPNPLPIIDVYGTRRGPKAK----PQKNADKHLLKQEQAQQEQQSQPLK 407

  Fly   350 ----------------PASDSGESMRSLENATPP--------MHFLTPHVEISTLGESGNTELF- 389
                            |.|..|.:.......|||        |..|.||            :||
Mosquito   408 QQELTNSGDQSPAPLTPLSQQGMATAPTTPFTPPGSGQTNGLMRNLFPH------------QLFP 460

  Fly   390 -NLICVWRESALQGNNNNNNNNNCATNNNNNINGASNNCNSISNGNAESNGDKVKDRALIMQSPV 453
             .|..:::.:|..|                     |.......|.|.:...|:
Mosquito   461 NPLAHMFKSAAANG---------------------SLPLFPYLNLNFQMFADQ------------ 492

  Fly   454 ELPMDCNTKATPITSSTTASSLSGGLKSHHQHPHHHHHHHHHHENHITPSISLIPIKQEPMSEDM 518
                                  ..||:...|                  .:|....:|..|::..
Mosquito   493 ----------------------QAGLQQQQQ------------------QLSPRTFQQNLMNQLA 517

  Fly   519 DKKDLMNGSDPSSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLKRRICAKA---NNRITR 580
            .:|  :|||..||.::|   :|:.|         ::.|...|.|.|:|.::|.|.|   :..:.|
Mosquito   518 GEK--LNGSATSSGSDQ---DNDLS---------VRTSSSGSTLGEELLKQITAAAADSSAAVGR 568

  Fly   581 NATPLESNNNN----------------SVLSNSLS-NGSGRGSPGVNGG-----------SGGGG 617
            ||.|.|.:.:.                ||.||..: :.:|:|......|           :...|
Mosquito   569 NALPQEDSESETTQAAPLQASFDEFPASVSSNPRTPSTTGKGERSRRKGRAFKLERLTEPATSSG 633

  Fly   618 GGGPPTPATPSATNGASSTPICNGTITSTGQDGDLLINRKLILTCHFCGIEFPDETLYFLHKGCH 682
            |..........|...|.|||:   |:....:.......|.  |.|.:|.|.|.|:.||.:|.|.|
Mosquito   634 GSNDMDTHYEHAEEAAVSTPV---TVAVARESPAPPKERS--LECKYCDIAFRDDVLYTIHMGYH 693

  Fly   683 CESNPWRCNICGEQLNNVYEFNSHLLSKSH 712
            ...:.::||:|||:.::...|..|:..|:|
Mosquito   694 GYDDVFKCNMCGEKSDDRIGFFLHIARKAH 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	3/19 (16%)
		zf-H2C2_2	195..218	CDD:463886	6/22 (27%)
		C2H2 Zn finger	211..231	CDD:275368	7/22 (32%)
		C2H2 Zn finger	239..255	CDD:275368	3/15 (20%)
		C2H2 Zn finger	662..689	CDD:275371	10/26 (38%)
		C2H2 Zn finger	690..712	CDD:275371	8/21 (38%)
hb	XP_061510668.1	None