DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and IKZF1

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_011513360.1	Gene:	IKZF1 / 10320	HGNCID:	13176	Length:	563	Species:	Homo sapiens

Alignment Length:	700	Identity:	141/700 - (20%)
Similarity:	228/700 - (32%)	Gaps:	239/700 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EPRSPTPTPTNLST---GPHSPP-----MTFRCERCDSFETSSRASLLLHVVQCLAGQAAAAAAA 119
            |...|.|.|.:|||   |..|..     :|:..:....|.                    |....
Human    50 EGDEPMPIPEDLSTTSGGQQSSKSDRVVVTYGADDFRDFH--------------------AIIPK 94

  Fly   120 AAASARLKSEDLQEPENMSLGHMEGGK---------GDGQTGNGSSSSASSSPAGNSGGGGGGNS 175
            :.:.:.:|.|...:.||.....|.|.:         ..|:..|||.....||..    .|.||..
Human    95 SFSPSNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSAL----SGVGGIR 155

  Fly   176 SSRKVFECDVCNMKFSNGAN-MRRHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHC 239
            ......:||:|.: ...|.| :..||..|||.:|::|..|...|.:|.:|..|...|:...|:.|
Human   156 LPNGKLKCDICGI-ICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKC 219

  Fly   240 PICNRGFQRQIAMRAHFQNEHVGQ-HDLVKTCPLC--SYRAGSMKSLRIHFFNRHGIDLDNPGPG 301
            .:||...:|:.|:..|.:...||: |    .|..|  ||:..|  ||..|....|..
Human   220 HLCNYACRRRDALTGHLRTHSVGKPH----KCGYCGRSYKQRS--SLEEHKERCHNY-------- 270

  Fly   302 GTSSLLLALESQASAAAAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSL----- 361
                    |||..           :|..|.||..:..:..:..:.:....|:     |||
Human   271 --------LESMG-----------LPGTLYPVIKEETNHSEMAEDLCKIGSE-----RSLVLDRL 311

  Fly   362 ------ENATPPMHFLTPHVEISTLGESGNTELFNLICVWRESALQGNNNNNNNNNC---ATNNN 417
                  ..::.|..|         ||:.|.::     ..:..||.....|....::.   |.||.
Human   312 ASNVAKRKSSMPQKF---------LGDKGLSD-----TPYDSSASYEKENEMMKSHVMDQAINNA 362

  Fly   418 NNINGASNNCNSISNGNAESNGDKVKDRALIMQSPVELPMDCNTKATPITSSTTASSLSGGLKSH 482
            .|..||.:.                  |.|:...|                        ||
Human   363 INYLGAESL------------------RPLVQTPP------------------------GG---- 381

  Fly   483 HQHPHHHHHHHHHHENHITPSISLIPIKQEPMSEDMDKKDLMNGSDPSSDTEQASNNNNSSSNNN 547
                           :.:.|.||.:....:|::|                   .:..:|.|:.::
Human   382 ---------------SEVVPVISPMYQLHKPLAE-------------------GTPRSNHSAQDS 412

  Fly   548 RITSLIKVSPLKSLLREDLKRRICAKANNRITRNATPLESNNNNS-----VLSNSLSNGSGRGSP 607
            .:.:|:.:|..|.:..|    |..:.:|:  .:::|..||||...     .|:|.::
Human   413 AVENLLLLSKAKLVPSE----REASPSNS--CQDSTDTESNNEEQRSGLIYLTNHIA-------- 463

  Fly   608 GVNGGSGGGGGGGPPTPATPSATNGASSTPICNG-----TITSTGQDGDLLIN----RKLILTCH 663
                               |.|.||.|.......     ..:...||...:::    :..:..|.
Human   464 -------------------PHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCE 509

  Fly   664 FCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSKSHQ 713
            .|.:.|.|..:|.:|.|||...:|:.||:||....:.|||:||:....|:
Human   510 HCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHR 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	7/20 (35%)
		zf-H2C2_2	195..218	CDD:290200	9/23 (39%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	5/15 (33%)
		C2H2 Zn finger	662..689	CDD:275371	10/26 (38%)
		C2H2 Zn finger	690..712	CDD:275371	9/21 (43%)
IKZF1	XP_011513360.1	C2H2 Zn finger	163..183	CDD:275368	7/20 (35%)
		zf-H2C2_2	176..200	CDD:372612	9/23 (39%)
		COG5048	187..>343	CDD:227381	45/207 (22%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		zf-H2C2_2	203..228	CDD:372612	7/24 (29%)
		C2H2 Zn finger	219..239	CDD:275368	6/19 (32%)
		C2H2 Zn finger	247..268	CDD:275368	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4359
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960