DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12769 and ZNF267

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_003405.4	Gene:	ZNF267 / 10308	HGNCID:	13060	Length:	743	Species:	Homo sapiens

Alignment Length:	219	Identity:	50/219 - (22%)
Similarity:	77/219 - (35%)	Gaps:	63/219 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 HSPPMTFRCERC-DSFETSSRASLLLHVVQ----------CLAGQAAAAAAAAAASARLKSEDLQ 132
            |:....::||:| ||...|      ||:.|          |...:.........:....|.:.:.
Human   316 HNEEKPYKCEKCGDSLNHS------LHLTQHQIIPTEEKPCKWKECGKVFNLNCSLYLTKQQQID 374

  Fly   133 EPENMSLGHMEGGKGDGQTGNGSSSSASSSPAGNSGGGGGGNSSSRKVFECDVCNMKFSNGANMR 197
            ..||:                                           ::|..|:..|:..:|:.
Human   375 TGENL-------------------------------------------YKCKACSKSFTRSSNLI 396

  Fly   198 RHKMRHTGVKPYECRVCQKRFFRKDHLAEHFTTHTKTLPYHCPICNRGFQRQIAMRAHFQNEHVG 262
            .|:..|||.|||:|:.|.|.|....:|.:|...||...||.|..|.:.|.|...:..| |..|.|
Human   397 VHQRIHTGEKPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQH-QTTHTG 460

  Fly   263 QHDLVKTCPLCSYRAGSMKSLRIH 286
            : .|.| |.:||.......:|.:|
Human   461 E-KLYK-CKVCSKSYARSSNLIMH 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		zf-H2C2_2	195..218	CDD:290200	11/22 (50%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..255	CDD:275368	4/15 (27%)
		C2H2 Zn finger	662..689	CDD:275371
		C2H2 Zn finger	690..712	CDD:275371
ZNF267	NP_003405.4	KRAB	4..64	CDD:214630
		C2H2 Zn finger	269..289	CDD:275368
		C2H2 Zn finger	297..316	CDD:275368	50/219 (23%)
		C2H2 Zn finger	324..341	CDD:275368	9/22 (41%)
		C2H2 Zn finger	353..374	CDD:275368	1/20 (5%)
		COG5048	364..730	CDD:227381	39/165 (24%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	6/20 (30%)
		C2H2 Zn finger	466..486	CDD:275368	5/17 (29%)
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	522..542	CDD:275368
		C2H2 Zn finger	550..570	CDD:275368
		C2H2 Zn finger	578..598	CDD:275368
		C2H2 Zn finger	606..626	CDD:275368
		C2H2 Zn finger	634..654	CDD:275368
		C2H2 Zn finger	662..682	CDD:275368
		C2H2 Zn finger	690..710	CDD:275368
		C2H2 Zn finger	718..738	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910