DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12769 and trps1

DIOPT Version :9

Sequence 1:	NP_001286181.1	Gene:	CG12769 / 35770	FlyBaseID:	FBgn0033252	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_004915118.1	Gene:	trps1 / 100493561	XenbaseID:	XB-GENE-1013667	Length:	1270	Species:	Xenopus tropicalis

Alignment Length:	1043	Identity:	197/1043 - (18%)
Similarity:	301/1043 - (28%)	Gaps:	395/1043 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DMTPTTAALLHHNAMALRSLKDAAS---SASESELQEPRSPTPTPTN-------------LSTGP 78
            |:...|..|..||.:.....||...   |.....||:..|..|...|             :..|.
Frog   251 DVELDTKILALHNMVQFSQSKDFQKMNRSVLSGVLQDINSQRPVLLNGTYDVQVTFGGTFIGIGR 315

  Fly    79 HSPPMT-----FRCERCD-SFETSSRASLLLHVVQCLAGQAAAAAAAAAASARLKSEDLQEPENM 137
            .:|...     |||:.|: ::..:|...|..|.::....:...::.:...|.:..::....|.:.
Frog   316 KTPDCQGNTKYFRCKFCNFTYMGNSATELEQHFLKTHPNKMKMSSDSGKPSEKSTNKSSPIPRSC 380

  Fly   138 SLGHMEGGKG-----------------------DGQTGNGS----------------SSSASSSP 163
            ..|.:  ||.                       |....||:                |||.|...
Frog   381 EPGDL--GKWQDKITVKAADDIPVGYSVPIKPVDSCRQNGTDDTNYYWCKFCSFSCESSSNSKLL 443

  Fly   164 AGNSGGGGGGNSSS------RKVFECDVCNM-------------KFSNGANMRRH----KMRHTG 205
            ..:|...|||.|.|      .|:|...|.|.             |...|...::.    ......
Frog   444 EHHSKQHGGGKSESPNSDMNDKIFRGSVINQNEITKSSDEQLPTKIEKGLAKKKDVSSVPTEDII 508

  Fly   206 VKPYECRVCQKRFFRKD------------HLAEHFTTHTKTLPYHCPICNRGF---QRQI----- 250
            |..|.|:.|..|:.:..            |..:|...|..|:. |||.|.||.   ::.:
Frog   509 VTNYNCQFCDFRYSKSHGPEVILVGPLLRHYQQHHNIHKCTIK-HCPFCPRGLCSPEKHLGEITY 572

  Fly   251 --------------------------------------------AMRAHFQNEHVGQ-------- 263
                                                        .:..|::|.|..|
Frog   573 PFACKKSNCSHCALLLLHLSAGVTGSTRVKHQCDQCSFSSPDVDVLLLHYENAHEAQACEVKQEL 637

  Fly   264 -----------------HDLVK----------------------TCPLCSYRAGSMKSLRIHFFN 289
                             |...|                      .|..|::.|...:||..||.:
Frog   638 NHQHGADGQPSIKESKEHSCTKCDFIVQVEEDLSRHYRRVHNCYKCRQCNFTAADTQSLLDHFNS 702

  Fly   290 RH----GIDLDNPGP-GGTSSL------------LLALESQASAA-------------------- 317
            .|    .|...|.|. .|.||:            |:|.:|:...|
Frog   703 AHCQESEITTSNGGEHHGASSIKEEPKTDLKVYNLVAPDSKMGEAIFDSTVKKEKLEDKETLREK 767

  Fly   318 -------------------AAAAAASYVPPGLSPVPVQSQSQQQQQQQVAPPASDSGESMRSLEN 363
                               ....:.||...||..:...|.:|:||:.....|..::....|
Frog   768 SWSDSAVDDLRGVAWRAPDILRTSPSYSQMGLGLLTTVSVNQEQQKSSRDSPNVEAAHLAR---- 828

  Fly   364 ATPPMHFLTPHVEIS-----TLGESG-----NTELFNLICVWRESALQGNNNNNNNN-------- 410
               |::.|:  :|..     |.|.||     :|..:       .:|..|.:.:.:.:
Frog   829 ---PLYGLS--IESKGFQGVTAGASGEKSGQHTPQY-------PTAGDGKSKDESQSLLRRRRGS 881

  Fly   411 -----NCATNNNN----NING--ASNNC-------------NSISNGNAESNGDKVKDRALIMQS 451
                 ||.|...:    |.||  ..|.|             |.|...|.|   ..::.|.....:
Frog   882 GVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGE---QIIRRRTRKRLN 943

  Fly   452 PVEL-PMDCNTKATPIT-SSTTASSLSGGLKSHHQHPHHHHH-----HHHHHENHITPSISLIPI 509
            |..| |...|....|.: .....|.|....:.|....|...:     :.:..:..:|.|.|
Frog   944 PEALQPEQLNKHQRPSSEEQANGSPLERRSEDHSMEGHQRENQQLSMNKYESQASLTKSHS---- 1004

  Fly   510 KQEPM--SEDMDKKDLMNGSDP-----SSDTEQASNNNNSSSNNNRITSLIKVSPLKSLLREDLK 567
            .|:.|  |:.||....|   .|     .|..|.:....||||.::...|..:.||::..:| .:|
Frog  1005 AQQTMIVSQTMDIHKRM---QPLHIQIKSPQESSGEPGNSSSVSDGKGSSERGSPIEKYMR-PIK 1065

  Fly   568 RRICAKANNRITRNATPL-------------------ESNNNNSVLSNS--LSNGSGRGSPGVN- 610
            ....:...:.|.:...||                   .|....||..|.  ||:..|..:|..|
Frog  1066 HPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCPNY 1130

  Fly   611 -----------GGSGGGGGGGPPTPATP-----SATNGA----SSTPICNGTITSTGQDGDLLIN 655
                       ..|.|.....|...|..     |.||||    |.:|:      |...||.|.:.
Frog  1131 VPYPTFNLPAQYSSVGSDNDIPLDLAMKHSRPGSGTNGASKEKSKSPL------SAKDDGPLNVT 1189

  Fly   656 R----------KLILTCHFCGIEFPDETLYFLHKGCHCESNPWRCNICGEQLNNVYEFNSHLLSK 710
            :          :|...|..|||.|.||.:|.||..||.|:.|::|:||.....:.|:|.:|:...
Frog  1190 KIEKSDKSTQDELSTKCVHCGIVFLDEVMYALHMSCHGENGPFQCSICQHLCTDKYDFTTHIQRG 1254

  Fly   711 SHQ 713
            .|:
Frog  1255 LHR 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12769	NP_001286181.1	C2H2 Zn finger	183..203	CDD:275368	4/36 (11%)
		zf-H2C2_2	195..218	CDD:290200	4/26 (15%)
		C2H2 Zn finger	211..231	CDD:275368	5/31 (16%)
		C2H2 Zn finger	239..255	CDD:275368	5/67 (7%)
		C2H2 Zn finger	662..689	CDD:275371	14/26 (54%)
		C2H2 Zn finger	690..712	CDD:275371	6/21 (29%)
trps1	XP_004915118.1	ZnF_GATA	884..940	CDD:238123	13/58 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3390
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030