Protein Alignment CG14762 and SLIT2

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: XP_005248268.1
• Gene: SLIT2 / 9353
• HGNCID: 11086
• Length: 1533
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 128/495 - (25%)
• Similarity: 182/495 - (36%)
• Gaps: 149/495 - (30%)

  Fly   112 HNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGL 176
            |..:|.::..|    :.....:||::.|.:..:.......|.||.:|.|..|||:.|...||:.|
Human    42 HGLALRSVPRN----IPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDL 102

  Fly   177 ETLEILTLYENKITQIDPE-AFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRT 240
            :.||.|.|..|.: |:.|| .|.|.. .:.||:|..|.:..||:||......:|.|::..|:|..
Human   103 KELERLRLNRNHL-QLFPELLFLGTA-KLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165

  Fly   241 ISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLL-------NSL------------------- 279
            |.:|.|..|:.|:.|.|.:|.||.:....|:|:..|       |:|
Human   166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRV 230

  Fly   280 ----------ELEGNKISVIDKDAF-------------------------------------KG- 296
                      .|.|:.::.:.|..|                                     ||
Human   231 GLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGL 295

  Fly   297 ------LEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNL 355
                  |.|.:..:||..|.|..||..|..|..:||.:||.||.|:.||.|||.|. .||..|.|
Human   296 TEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGL-RSLNSLVL 359

  Fly   356 QKNDIKVLPSLLFE------------------------NLNSLETLNLQNNKLQRIPQDIMEPVI 396
            ..|.|..||..|||                        :|::|..|:|.:||||.|.:....| :
Human   360 YGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSP-L 423

  Fly   397 DTLRIIDITDNPLNCSCELTWFPKLLED---------------LKNKDDEMSQKKKPLCHMSLDN 446
            ..::.:.:..||..|.|.|.|....|..               |.||.....:.||..|..   .
Human   424 RAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA---K 485

  Fly   447 REYFVQ-----------------AMPTEKMHCAGLNVSPS 469
            .:||:.                 |.| ||..|.|..|..|
Human   486 EQYFIPGTEDYRSKLSGDCFADLACP-EKCRCEGTTVDCS 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380
		leucine-rich repeat	107..129	CDD:275380	3/16 (19%)
		LRR	<131..410	CDD:443914	104/383 (27%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	10/24 (42%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		leucine-rich repeat	276..300	CDD:275380	10/103 (10%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	13/23 (57%)
		leucine-rich repeat	350..373	CDD:275380	11/46 (24%)
SLIT2	XP_005248268.1	LRRNT	27..58	CDD:214470	3/19 (16%)
		leucine-rich repeat	38..56	CDD:275380	3/17 (18%)
		LRR	<56..>211	CDD:443914	51/156 (33%)
		leucine-rich repeat	57..80	CDD:275380	4/22 (18%)
		leucine-rich repeat	81..104	CDD:275380	10/22 (45%)
		leucine-rich repeat	105..128	CDD:275380	10/24 (42%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..176	CDD:275380	8/22 (36%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		PCC	182..>260	CDD:188093	13/77 (17%)
		leucine-rich repeat	201..329	CDD:275380	19/127 (15%)
		LRRNT	276..308	CDD:214470	4/31 (13%)
		LRR	<323..671	CDD:443914	59/208 (28%)
		leucine-rich repeat	330..353	CDD:275380	13/23 (57%)
		leucine-rich repeat	354..374	CDD:275380	9/19 (47%)
		leucine-rich repeat	378..401	CDD:275380	1/22 (5%)
		leucine-rich repeat	402..423	CDD:275380	9/21 (43%)
		leucine-rich repeat	426..527	CDD:275380	23/103 (22%)
		LRR	519..>865	CDD:443914	2/6 (33%)
		leucine-rich repeat	541..563	CDD:275380
		leucine-rich repeat	564..587	CDD:275380
		leucine-rich repeat	588..611	CDD:275380
		leucine-rich repeat	612..635	CDD:275380
		leucine-rich repeat	636..659	CDD:275380
		leucine-rich repeat	660..751	CDD:275380
		leucine-rich repeat	752..782	CDD:275380
		leucine-rich repeat	783..806	CDD:275380
		leucine-rich repeat	807..830	CDD:275380
		leucine-rich repeat	831..852	CDD:275380
		PCC	836..>1017	CDD:188093
		leucine-rich repeat	855..867	CDD:275378
		EGF_CA	1002..1038	CDD:238011
		EGF_CA	1042..1077	CDD:238011
		EGF_CA	1080..1116	CDD:238011
		EGF_CA	<1134..1161	CDD:238011
		LamG	1187..1320	CDD:214598