DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14762 and SLIT2

DIOPT Version :9

Sequence 1:NP_001246198.1 Gene:CG14762 / 35768 FlyBaseID:FBgn0033250 Length:498 Species:Drosophila melanogaster
Sequence 2:XP_005248268.1 Gene:SLIT2 / 9353 HGNCID:11086 Length:1533 Species:Homo sapiens


Alignment Length:495 Identity:128/495 - (25%)
Similarity:182/495 - (36%) Gaps:149/495 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 HNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGL 176
            |..:|.::..|    :.....:||::.|.:..:.......|.||.:|.|..|||:.|...||:.|
Human    42 HGLALRSVPRN----IPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDL 102

  Fly   177 ETLEILTLYENKITQIDPE-AFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRT 240
            :.||.|.|..|.: |:.|| .|.|.. .:.||:|..|.:..||:||......:|.|::..|:|..
Human   103 KELERLRLNRNHL-QLFPELLFLGTA-KLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165

  Fly   241 ISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLL-------NSL------------------- 279
            |.:|.|..|:.|:.|.|.:|.||.:....|:|:..|       |:|                   
Human   166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRV 230

  Fly   280 ----------ELEGNKISVIDKDAF-------------------------------------KG- 296
                      .|.|:.::.:.|..|                                     || 
Human   231 GLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGL 295

  Fly   297 ------LEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNL 355
                  |.|.:..:||..|.|..||..|..|..:||.:||.||.|:.||.|||.|. .||..|.|
Human   296 TEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGL-RSLNSLVL 359

  Fly   356 QKNDIKVLPSLLFE------------------------NLNSLETLNLQNNKLQRIPQDIMEPVI 396
            ..|.|..||..|||                        :|::|..|:|.:||||.|.:....| :
Human   360 YGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSP-L 423

  Fly   397 DTLRIIDITDNPLNCSCELTWFPKLLED---------------LKNKDDEMSQKKKPLCHMSLDN 446
            ..::.:.:..||..|.|.|.|....|..               |.||.....:.||..|..   .
Human   424 RAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA---K 485

  Fly   447 REYFVQ-----------------AMPTEKMHCAGLNVSPS 469
            .:||:.                 |.| ||..|.|..|..|
Human   486 EQYFIPGTEDYRSKLSGDCFADLACP-EKCRCEGTTVDCS 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14762NP_001246198.1 leucine-rich repeat 85..105 CDD:275380
LRR_RI 93..384 CDD:238064 100/376 (27%)
leucine-rich repeat 107..129 CDD:275380 3/16 (19%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
LRR_8 154..214 CDD:290566 25/60 (42%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
leucine-rich repeat 179..203 CDD:275380 10/24 (42%)
leucine-rich repeat 204..227 CDD:275380 8/22 (36%)
LRR_8 226..286 CDD:290566 21/95 (22%)
leucine-rich repeat 228..251 CDD:275380 8/22 (36%)
leucine-rich repeat 252..275 CDD:275380 8/22 (36%)
LRR_8 276..335 CDD:290566 25/138 (18%)
leucine-rich repeat 276..300 CDD:275380 10/103 (10%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..349 CDD:275380 13/23 (57%)
LRR_8 349..409 CDD:290566 22/83 (27%)
leucine-rich repeat 350..373 CDD:275380 11/46 (24%)
SLIT2XP_005248268.1 LRRNT 27..58 CDD:214470 3/19 (16%)
leucine-rich repeat 38..56 CDD:275380 3/17 (18%)
LRR_8 55..115 CDD:404697 20/59 (34%)
leucine-rich repeat 57..80 CDD:275380 4/22 (18%)
internalin_A 73..>434 CDD:380193 99/364 (27%)
leucine-rich repeat 81..104 CDD:275380 10/22 (45%)
leucine-rich repeat 105..128 CDD:275380 10/24 (42%)
leucine-rich repeat 129..152 CDD:275380 8/22 (36%)
leucine-rich repeat 153..176 CDD:275380 8/22 (36%)
LRR_8 154..211 CDD:404697 18/56 (32%)
leucine-rich repeat 177..200 CDD:275380 8/22 (36%)
leucine-rich repeat 201..329 CDD:275380 19/127 (15%)
LRR_8 307..364 CDD:404697 26/57 (46%)
leucine-rich repeat 330..353 CDD:275380 13/23 (57%)
leucine-rich repeat 354..374 CDD:275380 9/19 (47%)
leucine-rich repeat 378..401 CDD:275380 1/22 (5%)
leucine-rich repeat 402..423 CDD:275380 9/21 (43%)
PCC 407..>470 CDD:188093 15/63 (24%)
leucine-rich repeat 426..527 CDD:275380 23/103 (22%)
LRRNT 509..539 CDD:214470 8/17 (47%)
leucine-rich repeat 541..563 CDD:275380
internalin_A 561..>858 CDD:380193
leucine-rich repeat 564..587 CDD:275380
leucine-rich repeat 588..611 CDD:275380
leucine-rich repeat 612..635 CDD:275380
leucine-rich repeat 636..659 CDD:275380
leucine-rich repeat 660..751 CDD:275380
leucine-rich repeat 752..782 CDD:275380
LRR_8 782..841 CDD:404697
leucine-rich repeat 783..806 CDD:275380
leucine-rich repeat 807..830 CDD:275380
leucine-rich repeat 831..852 CDD:275380
PCC 836..>1017 CDD:188093
leucine-rich repeat 855..867 CDD:275378
EGF_CA 1002..1038 CDD:238011
EGF_CA 1042..1077 CDD:238011
EGF_CA 1080..1116 CDD:238011
hEGF 1134..1155 CDD:403759
LamG 1187..1320 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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