Protein Alignment CG14762 and LINGO1

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_116197.4
• Gene: LINGO1 / 84894
• HGNCID: 21205
• Length: 620
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 105/398 - (26%)
• Similarity: 175/398 - (43%)
• Gaps: 48/398 - (12%)

  Fly    22 VLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYL 86
            :||:..||.   .....||.:     |.|:.:...  :||      |..:.:...:|.......|
Human    28 LLVLGSVLS---GSATGCPPR-----CECSAQDRA--VLC------HRKRFVAVPEGIPTETRLL 76

  Fly    87 KLRHNNLPKLQGFVFLAL-DIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQ 150
            .|..|.:..|....|.:. .:..|.::.:.::|:|..|.::| ..|..|.:..|::|.:|.....
Human    77 DLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNL-FNLRTLGLRSNRLKLIPLGVFT 140

  Fly   151 HLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLT 215
            .|.:|..|:::.|||.::.:..|:.|..|:.|.:.:|.:..|...||.|| :.:::|.|...:||
Human   141 GLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL-NSLEQLTLEKCNLT 204

  Fly   216 NIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAH-NMITTVPANVFSHLTLLNSL 279
            :||.:|||.|..|..|.::...|..|.:..|:.|..|..|.::| ..:.|:..|....|. |.||
Human   205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSL 268

  Fly   280 ELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFT 344
            .:....::.:...|.:.| ..|::|.|..|.|.||....|..|.||:.:.|....:.|:...||.
Human   269 SITHCNLTAVPYLAVRHL-VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFR 332

  Fly   345 GFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPL 409
            |. :.|..||:..|.:..|...:|.::.:||||                       |:|  .|||
Human   333 GL-NYLRVLNVSGNQLTTLEESVFHSVGNLETL-----------------------ILD--SNPL 371

  Fly   410 NCSCELTW 417
            .|.|.|.|
Human   372 ACDCRLLW 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/20 (25%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		LRR	<131..410	CDD:443914	78/279 (28%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	6/23 (26%)
		leucine-rich repeat	276..300	CDD:275380	5/23 (22%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	8/46 (17%)
		LRR	71..>371	CDD:443914	87/329 (26%)
		LRR 1	72..93		5/20 (25%)
		leucine-rich repeat	73..96	CDD:275380	5/22 (23%)
		LRR 2	96..117		4/20 (20%)
		leucine-rich repeat	97..120	CDD:275380	5/23 (22%)
		LRR 3	120..141		5/20 (25%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR 4	144..165		6/20 (30%)
		leucine-rich repeat	145..192	CDD:275380	15/47 (32%)
		LRR 5	168..189		6/20 (30%)
		LRR 6	192..213		8/20 (40%)
		leucine-rich repeat	193..216	CDD:275380	10/22 (45%)
		LRR 7	216..237		5/20 (25%)
		leucine-rich repeat	217..264	CDD:275380	11/46 (24%)
		LRR 8	264..285		4/21 (19%)
		leucine-rich repeat	265..288	CDD:275380	5/23 (22%)
		LRR 9	288..309		8/20 (40%)
		leucine-rich repeat	289..312	CDD:275380	9/22 (41%)
		LRR 10	312..333		6/20 (30%)
		leucine-rich repeat	313..336	CDD:275380	6/23 (26%)
		LRR 11	336..357		6/20 (30%)
		leucine-rich repeat	337..357	CDD:275380	6/19 (32%)
		PCC	341..>421	CDD:188093	17/64 (27%)
		IgI_Lingo-1	423..514	CDD:409561
		Ig strand A	423..426	CDD:409561
		Ig strand A'	431..435	CDD:409561
		Ig strand B	441..450	CDD:409561
		Ig strand C	455..460	CDD:409561
		Ig strand C'	463..465	CDD:409561
		Ig strand D	474..477	CDD:409561
		Ig strand E	480..487	CDD:409561
		Ig strand F	493..501	CDD:409561
		Ig strand G	504..514	CDD:409561