DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Lrrn3

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_110483.2	Gene:	Lrrn3 / 81514	RGDID:	71066	Length:	707	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	109/431 - (25%)
Similarity:	174/431 - (40%)	Gaps:	98/431 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 NNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHL 155
            |:|..|.....|..|.:.|.:..:::|.||.:  :.....||.||:|.|.:.:|.:..:|.:..|
  Rat    56 NDLGLLNFPARLPADTQILLLQTNNIARIEHS--TDFPVNLTGLDLSQNNLSSVTNINVQKMSQL 118

  Fly   156 LILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQK 220
            |.:.|..||:|.:......||..|:.|.:..|.::.|.|.||.||. ::.||:|..|.|..|..|
  Rat   119 LSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSAISPGAFVGLH-NLLRLHLNSNRLQMINSK 182

  Fly   221 ALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNK 285
            ....|..|:.|.:.:|.|..|.:.:|:.|..|.||::|...:|.||.
  Rat   183 WFEALPNLEILMLGDNPILRIKDMNFQPLLKLRSLVIAGINLTEVPG------------------ 229

  Fly   286 ISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSL 350
                  ||..|| |||:.:...||:::.:|..||:....|:.|||..|.||.:..      ||..
  Rat   230 ------DALVGL-ENLESISFYDNRLNKVPQVALQKAVNLKFLDLNKNPINRIRR------GDFS 281

  Fly   351 TFLNLQKNDIKVLPSLL-------------------------------FENLNSLETLNLQNNKL 384
            ..|:|::..|..:|.|:                               |..|..||:|.|.:|.|
  Rat   282 NMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNAL 346

  Fly   385 QRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREY 449
            ..:....:|. :..|:.|.|..||:.|.|.:.|.                      :|:..|
  Rat   347 SALYHGTIES-LPNLKEISIHSNPIRCDCVIRWI----------------------NMNKTN--- 385

  Fly   450 FVQAMPTEKMHCAGLNVSPSPTSGGLMRILQVNILAQIAVC 490
             ::.|..:.:.|    |.|....|  ..:.||:....:.:|
  Rat   386 -IRFMEPDSLFC----VDPPEFQG--QNVRQVHFRDMMEIC 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/13 (31%)
		LRR_RI	93..384	CDD:238064	88/321 (27%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	154..214	CDD:290566	21/59 (36%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	14/59 (24%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	17/58 (29%)
		leucine-rich repeat	276..300	CDD:275380	4/23 (17%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	8/23 (35%)
		LRR_8	349..409	CDD:290566	18/90 (20%)
		leucine-rich repeat	350..373	CDD:275380	7/53 (13%)
Lrrn3	NP_110483.2	LRRNT	28..72	CDD:214470	5/15 (33%)
		LRR 1	70..91		5/22 (23%)
		LRR	<72..355	CDD:227223	85/316 (27%)
		leucine-rich repeat	72..93	CDD:275380	4/22 (18%)
		LRR 2	93..114		7/20 (35%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		LRR 3	117..138		6/20 (30%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR 4	141..162		7/20 (35%)
		leucine-rich repeat	142..165	CDD:275380	9/23 (39%)
		LRR 5	165..186		7/20 (35%)
		leucine-rich repeat	166..189	CDD:275380	8/22 (36%)
		LRR 6	189..210		6/20 (30%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR 7	213..234		9/44 (20%)
		leucine-rich repeat	214..237	CDD:275380	11/47 (23%)
		LRR 8	237..258		7/20 (35%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR 9	261..282		9/26 (35%)
		leucine-rich repeat	262..285	CDD:275380	9/28 (32%)
		LRR 10	285..304		4/18 (22%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR 11	310..332		1/21 (5%)
		leucine-rich repeat	311..333	CDD:275380	1/21 (5%)
		LRR 12	335..358		7/23 (30%)
		leucine-rich repeat	336..359	CDD:275378	7/23 (30%)
		PCC	341..>405	CDD:188093	19/96 (20%)
		leucine-rich repeat	360..372	CDD:275378	5/11 (45%)
		Ig	440..513	CDD:416386
		Ig strand B	440..447	CDD:409353
		Ig strand C	453..458	CDD:409353
		Ig strand C'	461..464	CDD:409353
		Ig strand D	470..474	CDD:409353
		Ig strand E	479..483	CDD:409353
		Ig strand F	493..500	CDD:409353
		Ig strand G	503..513	CDD:409353
		fn3	526..593	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910