DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Cpn2

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	486	Identity:	134/486 - (27%)
Similarity:	203/486 - (41%)	Gaps:	86/486 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TQVCPEQSEIAPCICTVKKNGLDILCETTDLA--------HITKSMGTLKGKSPIIF----YLKL 88
            ||.||     ..|.|.    |.::.|....||        |||          .|:|    :..:
Mouse    19 TQPCP-----VGCDCF----GREVFCSDEQLADIPPDIPPHIT----------DIVFVETAFTTV 64

  Fly    89 R---HNNLPKLQGFVFLALDIRH--------------LTIHNSSLAAIEENALSSLGAGLTQLDV 136
            |   .:..|.|...|||...:||              |.|..|.::.:..:..|:| :.|.:|.:
Mouse    65 RTRAFSGSPNLTKVVFLNTQVRHLEPDAFGGLPRLQDLEITGSPVSNLSAHIFSNL-SSLEKLTL 128

  Fly   137 SLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLE 201
            ..:::..:|.....|:..|..|.|..|::..:....|:.|..|..|.|.:|.:||:...||:.|.
Mouse   129 DFDRLAGLPEDLFCHMDILESLQLQGNQLRTLPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQSLT 193

  Fly   202 DHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVP 266
            . ::.|.|..|.|..:|:.||..||:|::|.:..|.|..:|...|..|.||:.|.|.||.|..:|
Mouse   194 G-LQMLKLSNNMLARLPEGALGSLSSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLP 257

  Fly   267 ANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLR 331
            .::||.|..|..|.|:.|.:..:.:..| ...:.|.:|.|..||:.|||..|...|.||..|.|.
Mouse   258 VSLFSSLHNLTFLSLKDNALRTLPEGLF-AHNQGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLS 321

  Fly   332 NNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVI 396
            :|.|..|.|..|... :.|..|:|..|::..|...||.||:.|:.|||..|:|..:|..|.:...
Mouse   322 HNAITDLPEHVFRNL-EQLVKLSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTNY 385

  Fly   397 DTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPTEKMHC 461
            |...:. :..||..|.|.|::....|....|:               :.|...|          |
Mouse   386 DLFNLA-LLGNPWQCDCHLSYLTSWLRLYNNQ---------------ISNTHTF----------C 424

  Fly   462 AGLNVSPSPTSGGLMRILQVNILAQIAVCSV 492
            ||    |:...|.|:    .|:..:..:|.|
Mouse   425 AG----PAYLKGQLV----PNLKQEQLICPV 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	6/22 (27%)
		LRR_RI	93..384	CDD:238064	96/304 (32%)
		leucine-rich repeat	107..129	CDD:275380	7/35 (20%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		LRR_8	154..214	CDD:290566	18/59 (31%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	23/59 (39%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	276..335	CDD:290566	20/58 (34%)
		leucine-rich repeat	276..300	CDD:275380	5/23 (22%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..349	CDD:275380	8/23 (35%)
		LRR_8	349..409	CDD:290566	19/59 (32%)
		leucine-rich repeat	350..373	CDD:275380	9/22 (41%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470	9/39 (23%)
		LRR_8	73..133	CDD:290566	14/60 (23%)
		leucine-rich repeat	75..98	CDD:275380	6/22 (27%)
		LRR 1	98..119		3/20 (15%)
		leucine-rich repeat	99..122	CDD:275380	5/23 (22%)
		LRR_8	121..181	CDD:290566	14/59 (24%)
		LRR 2	122..143		3/20 (15%)
		leucine-rich repeat	123..146	CDD:275380	4/22 (18%)
		LRR 3	146..167		5/20 (25%)
		leucine-rich repeat	147..170	CDD:275380	6/22 (27%)
		LRR_RI	149..374	CDD:238064	79/227 (35%)
		LRR 4	170..191		8/20 (40%)
		LRR_8	171..229	CDD:290566	21/58 (36%)
		leucine-rich repeat	171..194	CDD:275380	9/22 (41%)
		LRR 5	194..215		7/21 (33%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		LRR_8	217..277	CDD:290566	23/59 (39%)
		LRR 6	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR 7	242..263		9/20 (45%)
		leucine-rich repeat	243..266	CDD:275380	10/22 (45%)
		LRR_8	266..325	CDD:290566	20/59 (34%)
		LRR 8	266..287		5/21 (24%)
		leucine-rich repeat	267..290	CDD:275380	5/23 (22%)
		LRR 9	290..311		9/20 (45%)
		leucine-rich repeat	291..314	CDD:275380	10/22 (45%)
		LRR_8	313..373	CDD:290566	23/60 (38%)
		LRR 10	314..335		9/20 (45%)
		leucine-rich repeat	315..338	CDD:275380	8/23 (35%)
		LRR 11	338..359		7/20 (35%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
		LRR 12	362..383		8/20 (40%)
		leucine-rich repeat	363..382	CDD:275380	8/18 (44%)
		LRRCT	395..436	CDD:214507	15/73 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910