Protein Alignment CG14762 and Lrfn2

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_081728.2
• Gene: Lrfn2 / 70530
• MGIID: 1917780
• Length: 788
• Species: Mus musculus
• Alignment Length: 298
• Identity: 79/298 - (26%)
• Similarity: 124/298 - (41%)
• Gaps: 70/298 - (23%)

  Fly   207 LNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFS 271
            |.||||.:.:|.::..:.::.|..|.:..|.|..|....|..|:||.||.|..|.:.::..:...
Mouse    57 LRLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLR 121

  Fly   272 HLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNIN 336
            .|..|..|.:..|::..|..|||:.....|:.|.|..|.:|.:|.:::|.:..|..|.|.:|.::
Mouse   122 GLVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLD 186

  Fly   337 VLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRI 401
            .:||.         ||.:|||                |..|:|.:|:||::|.|   |:....:.
Mouse   187 HIAEG---------TFADLQK----------------LARLDLTSNRLQKLPPD---PIFARSQA 223

  Fly   402 IDIT-------------DNPLNCSCELTWFPKLLEDLKNKDDEM-------SQKKKPLCHMSLDN 446
            ..:|             .|||:|:|||.|..:|     .:||::       |.|.:...|:   .
Mouse   224 SLLTATPFAPPLSFSFGGNPLHCNCELLWLRRL-----ERDDDLETCGSPGSLKGRYFWHI---R 280

  Fly   447 REYFVQAMPTEKMHCAGLNV--------------SPSP 470
            .|.||...|....|...|.|              .|||
Mouse   281 EEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSP 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380
		leucine-rich repeat	107..129	CDD:275380
		LRR	<131..410	CDD:443914	57/215 (27%)
		leucine-rich repeat	131..154	CDD:275380
		leucine-rich repeat	155..178	CDD:275380
		leucine-rich repeat	179..203	CDD:275380
		leucine-rich repeat	204..227	CDD:275380	6/19 (32%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		leucine-rich repeat	276..300	CDD:275380	7/23 (30%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
Lrfn2	NP_081728.2	LRR 1	53..74		6/16 (38%)
		leucine-rich repeat	54..77	CDD:275380	6/19 (32%)
		LRR	<56..>214	CDD:443914	51/181 (28%)
		LRR 2	77..98		6/20 (30%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		LRR 3	101..122		6/20 (30%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..150	CDD:275380	7/23 (30%)
		LRR 5	150..171		6/20 (30%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		LRR 6	174..195		8/29 (28%)
		leucine-rich repeat	175..198	CDD:275380	9/31 (29%)
		LRR 7	198..219		10/39 (26%)
		LRRCT	242..286	CDD:214507	16/51 (31%)
		Ig	289..376	CDD:472250	7/30 (23%)
		Ig strand B	306..310	CDD:409421	0/3 (0%)
		Ig strand C	319..323	CDD:409421	79/298 (27%)
		Ig strand E	342..346	CDD:409421
		Ig strand F	356..361	CDD:409421
		Ig strand G	369..372	CDD:409421
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..423
		fn3	428..493	CDD:394996
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..655
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..711
		PDZ-binding	785..788