DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14762 and SLIT1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_003052.2	Gene:	SLIT1 / 6585	HGNCID:	11085	Length:	1534	Species:	Homo sapiens

Alignment Length:	579	Identity:	130/579 - (22%)
Similarity:	200/579 - (34%)	Gaps:	197/579 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 CPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLA 103
            ||     |.|.||    |..:.|..|.|..|.|                    |:|:
Human    34 CP-----ALCTCT----GTTVDCHGTGLQAIPK--------------------NIPR-------- 61

  Fly   104 LDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVI 168
             :...|.::.:::..|.:|..    |||.||.|                     |.|..|:|..:
Human    62 -NTERLELNGNNITRIHKNDF----AGLKQLRV---------------------LQLMENQIGAV 100

  Fly   169 HNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEI 233
            ...||:.::.||.|.|..|::..: ||........:.||:|..|.:..||:||....:.||.|::
Human   101 ERGAFDDMKELERLRLNRNQLHML-PELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQL 164

  Fly   234 QENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGN-------------- 284
            .:|:|..|.||.|..|:.|:.|.|.:|.|||:|.:.|:|:..|.:..|..|
Human   165 DKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQW 229

  Fly   285 ----------------------KISVIDKDAF--------------------------------- 294
                                  .::.:.|..|
Human   230 LRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVD 294

  Fly   295 ---KG-------LEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTG---- 345
               ||       |.|.:..:||..|.|.:||..|..|..:||.:||.||.|..:|.|||.|
Human   295 CRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSL 359

  Fly   346 -----FGDSLT--------------FLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDI 391
                 :|:.:|              .|.|..|.|..:....|::|.:|..|:|.:||:|.:.:..
Human   360 NSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGT 424

  Fly   392 MEPVIDTLRIIDITDNPLNCSCELTWFPKLLED---------------LKNKDDEMSQKKKPLCH 441
            ... :..::.:.:..||..|.|.|.|....|..               |.||.....:.||..|.
Human   425 FTS-LRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCS 488

  Fly   442 MSLDNREYFVQAMPTEKMH--CAGLNVSPSPTSGGLMRILQVNILAQIAVCSVAFLTSV 498
            .   ..:||:......:::  |....|.|.          :....|.:..||...||.:
Human   489 A---KEQYFIPGTEDYQLNSECNSDVVCPH----------KCRCEANVVECSSLKLTKI 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	2/19 (11%)
		LRR_RI	93..384	CDD:238064	92/392 (23%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		LRR_8	154..214	CDD:290566	17/59 (29%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..203	CDD:275380	7/23 (30%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	23/95 (24%)
		leucine-rich repeat	228..251	CDD:275380	10/22 (45%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	276..335	CDD:290566	23/137 (17%)
		leucine-rich repeat	276..300	CDD:275380	8/102 (8%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	13/32 (41%)
		LRR_8	349..409	CDD:290566	14/73 (19%)
		leucine-rich repeat	350..373	CDD:275380	7/36 (19%)
SLIT1	NP_003052.2	LRRNT	33..64	CDD:214470	14/67 (21%)
		leucine-rich repeat	43..62	CDD:275380	7/47 (15%)
		LRR_8	61..121	CDD:290566	20/93 (22%)
		LRR 1	62..83		3/24 (13%)
		leucine-rich repeat	63..86	CDD:275380	6/26 (23%)
		LRR_4	64..101	CDD:289563	13/61 (21%)
		LRR 2	86..107		9/41 (22%)
		LRR_RI	<87..220	CDD:238064	46/154 (30%)
		leucine-rich repeat	87..110	CDD:275380	8/43 (19%)
		LRR_8	109..169	CDD:290566	19/60 (32%)
		LRR 3	110..131		7/21 (33%)
		leucine-rich repeat	111..134	CDD:275380	7/23 (30%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	158..179		9/20 (45%)
		LRR_8	159..217	CDD:290566	23/57 (40%)
		leucine-rich repeat	159..182	CDD:275380	10/22 (45%)
		LRR 6	182..203		9/20 (45%)
		leucine-rich repeat	183..206	CDD:275380	10/22 (45%)
		leucine-rich repeat	207..334	CDD:275380	17/126 (13%)
		TPKR_C2	219..264	CDD:301599	2/44 (5%)
		LRRNT	282..313	CDD:214470	4/30 (13%)
		LRR 7	310..331		7/20 (35%)
		LRR_8	312..369	CDD:290566	21/56 (38%)
		LRR_4	334..373	CDD:289563	14/38 (37%)
		LRR 8	334..355		11/20 (55%)
		leucine-rich repeat	335..358	CDD:275380	12/22 (55%)
		LRR 9	358..379		2/20 (10%)
		leucine-rich repeat	359..379	CDD:275380	2/19 (11%)
		LRR 10	382..403		5/20 (25%)
		leucine-rich repeat	383..406	CDD:275380	6/22 (27%)
		LRR_8	389..441	CDD:290566	11/52 (21%)
		LRR 11	406..427		6/20 (30%)
		leucine-rich repeat	407..428	CDD:275380	6/21 (29%)
		leucine-rich repeat	431..528	CDD:275380	20/109 (18%)
		TPKR_C2	439..>469	CDD:301599	7/29 (24%)
		LRRNT	513..542	CDD:214470	6/32 (19%)
		leucine-rich repeat	529..566	CDD:275380	2/6 (33%)
		LRR 12	541..562
		LRR_RI	<544..627	CDD:238064
		LRR_8	544..601	CDD:290566
		LRR 13	566..587
		leucine-rich repeat	567..590	CDD:275380
		LRR_8	590..649	CDD:290566
		LRR 14	590..611
		leucine-rich repeat	591..614	CDD:275380
		LRR 15	614..635
		LRR_4	615..654	CDD:289563
		leucine-rich repeat	615..638	CDD:275380
		LRR 16	638..659
		leucine-rich repeat	639..660	CDD:275380
		leucine-rich repeat	663..762	CDD:275380
		LRRCT	671..719	CDD:214507
		LRRNT	733..765	CDD:214470
		LRR_8	761..820	CDD:290566
		LRR 17	762..783
		leucine-rich repeat	763..785	CDD:275380
		LRR 18	785..806
		LRR_4	786..827	CDD:289563
		leucine-rich repeat	786..809	CDD:275380
		LRR 19	809..830
		leucine-rich repeat	810..830	CDD:275380
		LRR 20	833..854
		leucine-rich repeat	834..857	CDD:275380
LRRCT	866..915	CDD:214507
EGF_CA	927..962	CDD:238011
EGF_CA	966..1002	CDD:238011
EGF_CA	1005..1041	CDD:238011
EGF_CA	1044..1080	CDD:238011
EGF_CA	1085..1119	CDD:238011
EGF_CA	<1136..1163	CDD:238011
LamG	1189..1322	CDD:214598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910