Protein Alignment CG14762 and NYX

DIOPT Version :9

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001365406.2
• Gene: NYX / 60506
• HGNCID: 8082
• Length: 476
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 102/418 - (24%)
• Similarity: 166/418 - (39%)
• Gaps: 82/418 - (19%)

  Fly    16 VVLLLQVLVMDQVLGQGPPQ-------TQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSM 73
            :||||..:|:      |.|.       .:.||     |.|.|:..:.|..:.|:...|..:.
Human     2 LVLLLHAVVL------GLPSAWAVGACARACP-----AACACSTVERGCSVRCDRAGLLRVP--- 52

  Fly    74 GTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSL 138
                                                               :.|......:|:..
Human    53 ---------------------------------------------------AELPCEAVSIDLDR 66

  Fly   139 NQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYEN-KITQIDPEAFRGLED 202
            |.::.:..:|...|..|..|:|.||.::.|...||:||..|..|.|..| .:..:....|..| .
Human    67 NGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAAL-S 130

  Fly   203 HIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPA 267
            .::||:|....|.::|::.|:.|..|::|...:|..|.: .|...||.:|....|....|..|.:
Human   131 RLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHAHLERGRIEAVAS 194

  Fly   268 NVFSHLTLLNSLELEGNKISVIDKDAFK--GLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDL 330
            :....|..|.||.|:.|::..:...||.  |:   |::|.|.||.:..:|::|.|.|.|||.|:|
Human   195 SSLQGLRRLRSLSLQANRVRAVHAGAFGDCGV---LEHLLLNDNLLAELPADAFRGLRRLRTLNL 256

  Fly   331 RNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPV 395
            ..|.::.:|...|....: |..|.|.:|.|..:....|:||:.|..|:|..|:|..:.....:|.
Human   257 GGNALDRVARAWFADLAE-LELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPG 320

  Fly   396 IDTLRIIDITDNPLNCSCELTWFPKLLE 423
            ....|:. :..||..|.|.|.|....:|
Human   321 FFLGRLF-LFRNPWCCDCRLEWLRDWME 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	0/19 (0%)
		LRR_RI	93..384	CDD:238064	77/293 (26%)
		leucine-rich repeat	107..129	CDD:275380	1/21 (5%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		LRR_8	154..214	CDD:290566	19/60 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	6/24 (25%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_8	226..286	CDD:290566	17/59 (29%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	276..335	CDD:290566	23/60 (38%)
		leucine-rich repeat	276..300	CDD:275380	8/25 (32%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	16/59 (27%)
		leucine-rich repeat	350..373	CDD:275380	8/22 (36%)
NYX	NP_001365406.2	LRR_8	61..115	CDD:404697	17/53 (32%)
		leucine-rich repeat	63..82	CDD:275380	4/18 (22%)
		leucine-rich repeat	83..106	CDD:275380	10/22 (45%)
		leucine-rich repeat	107..131	CDD:275380	6/24 (25%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		PPP1R42	150..310	CDD:411060	51/164 (31%)
		leucine-rich repeat	156..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR_8	227..285	CDD:404697	21/58 (36%)
		leucine-rich repeat	227..250	CDD:275380	9/22 (41%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		leucine-rich repeat	275..296	CDD:275380	6/20 (30%)
		leucine-rich repeat	323..335	CDD:275378	3/12 (25%)
		LRRCT	331..>365	CDD:214507	7/17 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277227at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920