DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and LRRN1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001311117.1	Gene:	LRRN1 / 57633	HGNCID:	20980	Length:	716	Species:	Homo sapiens

Alignment Length:	418	Identity:	116/418 - (27%)
Similarity:	185/418 - (44%)	Gaps:	52/418 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVK---------KNGLDILCETTDL 66
            :.|:....|:..|:|.. |.:...|...||:.     |:|.::         :....:.|  .||
Human     5 SFVIAACQLVLGLLMTS-LTESSIQNSECPQL-----CVCEIRPWFTPQSTYREATTVDC--NDL 61

  Fly    67 AHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGL 131
             .:|:....|...:.:   |.|:.||:.|                      .::|  |..| ..|
Human    62 -RLTRIPSNLSSDTQV---LLLQSNNIAK----------------------TVDE--LQQL-FNL 97

  Fly   132 TQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEA 196
            |:||.|.|....:....|.:|..|..|:|..|:||.:.:...:.|..|:.|.:..|:|:.|...|
Human    98 TELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHA 162

  Fly   197 FRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNM 261
            |.||: ::.||:|..|.|..|..:.......|:.|.|.||.:..|.:.:|:.|.:|.||:||...
Human   163 FAGLK-NLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMY 226

  Fly   262 ITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLR 326
            :|.:|.|....|..|.||....||:..:.:.|.:.: .||::|.|..|.||.|.....:.:.||:
Human   227 LTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKV-PNLKFLDLNKNPIHKIQEGDFKNMLRLK 290

  Fly   327 HLDLRNNNINVLAEDAFTGFG-DSLTFLNLQKN-DIKVLPSLLFENLNSLETLNLQNNKLQRIPQ 389
            .|.: ||...:::.|.:.... ..||.|....| .:..:..|.|.::.:||:|.|.||.|..|.|
Human   291 ELGI-NNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQ 354

  Fly   390 DIMEPVIDTLRIIDITDNPLNCSCELTW 417
            ..:|. :..||.|.|..|||.|.|.:.|
Human   355 KTVES-LPNLREISIHSNPLRCDCVIHW 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	83/292 (28%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	154..214	CDD:290566	20/59 (34%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	226..286	CDD:290566	21/59 (36%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	9/22 (41%)
		LRR_8	276..335	CDD:290566	19/58 (33%)
		leucine-rich repeat	276..300	CDD:275380	6/23 (26%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	5/24 (21%)
		LRR_8	349..409	CDD:290566	21/60 (35%)
		leucine-rich repeat	350..373	CDD:275380	6/23 (26%)
LRRN1	NP_001311117.1	LRR_RI	13..273	CDD:238064	79/298 (27%)
		leucine-rich repeat	54..73	CDD:275380	5/21 (24%)
		LRR 1	73..95		8/49 (16%)
		leucine-rich repeat	74..96	CDD:275380	8/49 (16%)
		LRR 2	96..117		7/20 (35%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		LRR_8	119..179	CDD:290566	20/60 (33%)
		LRR 3	120..141		6/20 (30%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR 4	144..165		7/20 (35%)
		leucine-rich repeat	145..168	CDD:275380	9/23 (39%)
		LRR 5	168..189		6/20 (30%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR 6	192..213		7/20 (35%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		LRR_8	216..275	CDD:290566	20/59 (34%)
		LRR 7	216..237		8/20 (40%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		LRR_RI	240..>376	CDD:238064	43/138 (31%)
		LRR 8	240..261		6/20 (30%)
		leucine-rich repeat	241..264	CDD:275380	6/23 (26%)
		LRR_8	263..323	CDD:290566	17/60 (28%)
		LRR 9	264..285		8/20 (40%)
		leucine-rich repeat	265..288	CDD:275380	7/22 (32%)
		leucine-rich repeat	289..313	CDD:275380	5/24 (21%)
		LRR_8	312..373	CDD:290566	21/61 (34%)
		LRR 10	313..335		6/21 (29%)
		leucine-rich repeat	314..335	CDD:275380	6/20 (30%)
		LRR 11	338..359		9/20 (45%)
		leucine-rich repeat	339..362	CDD:275378	10/23 (43%)
		leucine-rich repeat	363..375	CDD:275378	7/11 (64%)
		LRRCT	371..419	CDD:214507	6/11 (55%)
		I-set	429..516	CDD:254352
		Ig	431..516	CDD:299845
		fn3	531..600	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910