DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and nyx

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001071085.1	Gene:	nyx / 568821	ZFINID:	ZDB-GENE-061026-3	Length:	469	Species:	Danio rerio

Alignment Length:	451	Identity:	121/451 - (26%)
Similarity:	184/451 - (40%)	Gaps:	109/451 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PPQ-------TQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYLKLRH 90
            ||.       |:.||     ..|.||.:|: ..:||:..::..:.|.           |..:...
Zfish    15 PPHALSLWACTRSCP-----PTCTCTQEKS-CSVLCDHVNMMDLPKE-----------FPCEASS 62

  Fly    91 NNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHL 155
            .||.|                  :||..:.|.|..                 |:||        |
Zfish    63 INLDK------------------NSLKFLSERAFG-----------------TLPS--------L 84

  Fly   156 LILNLNHNKITVIHNNAFEGLETLEILTLYENK-ITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQ 219
            ..|:|.:|.|:.|...||:||..|..|.:..|: |..:....|..|: .:.||:|...:|.|:|.
Zfish    85 KTLSLKYNNISFITPGAFKGLPNLVELKMAHNEYIRYLHTRTFTALK-RLVRLDLSDCNLFNMPD 148

  Fly   220 KALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGN 284
            :......|||:|...:|..|.: .|...|:::|..:.|..|.|..|..|....||.|..|.|:.|
Zfish   149 RIFLEQITLKELLCFQNNFRRV-PGALRGMENLTHVYLERNKIEAVAYNSLLGLTSLKYLNLQEN 212

  Fly   285 KISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGD- 348
            :|:||..:|||.| ..|:...|.||.:..:|.:|.:.|..|:.|:|..   |:|...:.|.|.|
Zfish   213 RINVIHDEAFKDL-IRLENFYLNDNLLVDLPQQAFKGLSNLKMLNLGG---NLLTNVSKTWFSDL 273

  Fly   349 -SLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCS 412
             .|..|.|.:|.:..:....||||.||.||:|.:|.|..:|..:.:|:....|:. :..||..|:
Zfish   274 VELEVLYLDRNRLSYIEDGSFENLTSLITLHLNSNNLTSLPFSVFQPIYFIGRLY-LFRNPWECT 337

  Fly   413 CELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPTEKMHCAGLNVSPSPTSG 473
            |:|.|..:.:|..|                       .|:.:|     ||    |||..:|
Zfish   338 CDLEWLREWMESYK-----------------------LVRDIP-----CA----SPSSVAG 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	3/19 (16%)
		LRR_RI	93..384	CDD:238064	87/293 (30%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..154	CDD:275380	3/22 (14%)
		LRR_8	154..214	CDD:290566	19/60 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	6/24 (25%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	226..286	CDD:290566	20/59 (34%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	21/58 (36%)
		leucine-rich repeat	276..300	CDD:275380	11/23 (48%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	8/25 (32%)
		LRR_8	349..409	CDD:290566	19/59 (32%)
		leucine-rich repeat	350..373	CDD:275380	8/22 (36%)
nyx	NP_001071085.1	leucine-rich repeat	64..83	CDD:275380	8/53 (15%)
		LRR_8	82..143	CDD:290566	21/69 (30%)
		leucine-rich repeat	84..107	CDD:275380	10/22 (45%)
		leucine-rich repeat	108..132	CDD:275380	6/24 (25%)
		LRR_RI	<127..311	CDD:238064	64/189 (34%)
		leucine-rich repeat	133..179	CDD:275380	14/46 (30%)
		LRR_8	179..238	CDD:290566	23/59 (39%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..227	CDD:275380	11/23 (48%)
		LRR_8	227..286	CDD:290566	19/61 (31%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	8/25 (32%)
		LRR_8	275..333	CDD:290566	18/58 (31%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..319	CDD:275380	7/18 (39%)
		LRRCT	332..>366	CDD:214507	15/65 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277227at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920