DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and lrrn1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001124166.1	Gene:	lrrn1 / 568527	ZFINID:	ZDB-GENE-071126-1	Length:	717	Species:	Danio rerio

Alignment Length:	533	Identity:	139/533 - (26%)
Similarity:	215/533 - (40%)	Gaps:	117/533 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCIC--TVKKNGLDILCETTDLAHITKSMGTL 76
            :..:|||.||.:..|.....||..||    ||.|...  :..:....:.|  .|| |:|:..|.|
Zfish    14 ICFILLLAVLGLSSVHSTECPQLCVC----EIRPWFTPQSTYREATTVDC--NDL-HLTRIPGNL 71

  Fly    77 KGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQM 141
            ...:.:   |.|:.|.:.:....:...|::..|.:..::.:.|.:..|::: :.||.|.:..||:
Zfish    72 SADTQV---LLLQSNYIARTSEELEQLLNLTELDLSQNNFSNIRDIGLTNM-SQLTTLHLEENQI 132

  Fly   142 KTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKR 206
            ..:|..:||.|.:|..|.:|||:|:.|..|||.||..|..|.|..|::..||...|....:
Zfish   133 VEMPDFSLQDLTNLQELYINHNQISSIAPNAFAGLRNLLRLHLNSNRLKAIDSRWFESTPN---- 193

  Fly   207 LNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFS 271
                                 |:.|.|.||.:..|.:.:|:.|.:|.||:||...:|.:|.|.|.
Zfish   194 ---------------------LEILMIGENPVVGILDLNFKPLTNLRSLVLAGMELTDIPGNAFV 237

  Fly   272 HLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNIN 336
            .|..|.||....||:..:.:.|.:.| .||::|.|..|.||.|.....:.:.||:.|.: ||...
Zfish   238 GLDNLESLSFYDNKLVRVPQTALQKL-PNLKFLDLNKNPIHKIQEGDFKNMLRLKELGI-NNMGE 300

  Fly   337 VLAEDAFTGFG-DSLTFLNLQKN-DIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTL 399
            :::.|.|.... ..||.|....| ....:..|.|.:|.:||:|.|.||.|..:.|...:. :..|
Zfish   301 LVSIDRFALDNLPELTKLEATNNPKFSYVSRLAFRDLPALESLMLNNNALNSLYQATADS-LPNL 364

  Fly   400 RIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKK------KPL---CHMSLD---------- 445
            |.|.|..|||.|.|.:.|              ||..|      :||   |.|.::
Zfish   365 REISIHSNPLRCDCVIQW--------------MSSNKTTIRFMEPLSMFCTMPIEVRGQRVRDVF 415

  Fly   446 NREYFVQAMP-----------------TEKMHCAGLNVSPSP----------------------- 470
            :||...|.:|                 |..:.|..: ..|.|
Zfish   416 SREPSGQCLPMISHDTFPNHLNLDIGMTVDLDCRAM-AEPEPEIYWVTPSGNKVMMDTVSDKYQL 479

  Fly   471 TSGGLMRILQVNI 483
            .|.|.:||..:.:
Zfish   480 NSAGTLRISYIQV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	3/19 (16%)
		LRR_RI	93..384	CDD:238064	85/292 (29%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR_8	154..214	CDD:290566	19/59 (32%)
		leucine-rich repeat	155..178	CDD:275380	12/22 (55%)
		leucine-rich repeat	179..203	CDD:275380	7/23 (30%)
		leucine-rich repeat	204..227	CDD:275380	0/22 (0%)
		LRR_8	226..286	CDD:290566	22/59 (37%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	276..335	CDD:290566	20/58 (34%)
		leucine-rich repeat	276..300	CDD:275380	7/23 (30%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	6/24 (25%)
		LRR_8	349..409	CDD:290566	20/60 (33%)
		leucine-rich repeat	350..373	CDD:275380	7/23 (30%)
lrrn1	NP_001124166.1	leucine-rich repeat	55..74	CDD:275380	7/21 (33%)
		LRR_RI	86..>276	CDD:238064	62/216 (29%)
		LRR_8	97..156	CDD:290566	17/59 (29%)
		leucine-rich repeat	98..121	CDD:275380	3/23 (13%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	12/22 (55%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		LRR_8	216..276	CDD:290566	22/60 (37%)
		leucine-rich repeat	218..241	CDD:275380	10/22 (45%)
		LRR_RI	242..401	CDD:238064	52/175 (30%)
		leucine-rich repeat	242..265	CDD:275380	7/23 (30%)
		LRR_8	264..324	CDD:290566	18/60 (30%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..314	CDD:275380	6/24 (25%)
		LRR_8	313..374	CDD:290566	20/61 (33%)
		leucine-rich repeat	315..337	CDD:275380	6/21 (29%)
		leucine-rich repeat	340..353	CDD:275378	7/12 (58%)
		leucine-rich repeat	364..376	CDD:275378	7/11 (64%)
		LRRCT	372..414	CDD:214507	13/55 (24%)
		IG_like	433..517	CDD:214653	8/61 (13%)
		Ig	441..517	CDD:299845	8/53 (15%)
		FN3	532..601	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910