DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and zgc:153913

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001073448.1	Gene:	zgc:153913 / 559700	ZFINID:	ZDB-GENE-061103-397	Length:	496	Species:	Danio rerio

Alignment Length:	490	Identity:	121/490 - (24%)
Similarity:	203/490 - (41%)	Gaps:	93/490 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMG 74
            |.:|:.|::.|...|             .|||     ||.|.   :|..::|...
Zfish     5 CAVVLLVLIHLYCGV-------------CCPE-----PCQCF---SGSKLVCSDD---------- 38

  Fly    75 TLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENA------LSSLGAGLTQ 133
                          |..:||     |.::..:|.|.:..|.:..:::.:      ||.|
Zfish    39 --------------RMKSLP-----VNISTQVRELIVVASGIPDLDQQSFPETLRLSKL------ 78

  Fly   134 LDVSLNQM-KTVPSQALQHLFHLLILNLNHNKITV-IHNNAFEGLETLEILTLYENKITQIDPEA 196
              |.||.| |:|..:|.:.|..|..|.::.|...: :....|..|..|..|.|..||::.:|...
Zfish    79 --VFLNGMLKSVSGEAFERLVELRELEISGNICWMSLDIQTFSSLTNLTRLLLNNNKLSGVDAGL 141

  Fly   197 FRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNM 261
            |..|. .::.|.|.||.|:.:..:....|..|::|::..|:|.::|...|:....|..|.|..|.
Zfish   142 FHSLH-QLEMLQLRGNGLSFLSGRLFQRLHRLQELDLSFNQISSLSTELFQNNSELRVLSLQANK 205

  Fly   262 ITTVPANVFSHLTLLNSLELEGNKISVIDKDAF----------KGLEENL-----------QYLR 305
            |..:|..:|:||..|..|.|..|.|.|:...:|          |.|.|.|           .||.
Zfish   206 IPNLPDGIFTHLDHLQELNLRSNLIRVLTPGSFPASLKTLILKKNLLEKLTNAVFHTLHYITYLD 270

  Fly   306 LGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFEN 370
            |..|.:..:|::..:.|..|..|||..|.|:.||...|.|. .|:..:.||||.:..:.:.|.::
Zfish   271 LSQNSLTEVPADLFQNLISLETLDLSENRISTLAGSVFKGL-FSIKSVYLQKNSLISVDAHLLKD 334

  Fly   371 LNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQK 435
            .:.|:.|:|.||.|:.||....|. :|...:.::..||.:|.|.:.:|   .:.||.....:...
Zfish   335 QHDLQLLDLSNNSLRSIPSGFFED-LDFQCVFELRGNPWSCDCGIHYF---YDWLKYNHKHVKDL 395

  Fly   436 KKPLCHMSLDNREYFVQAMPTEKMHCAGLNVSPSP 470
            .:..|......:.:.::::..|::.|:..:.|.||
Zfish   396 SRVSCEAPELIQGHNLRSVDREQLVCSRNSSSNSP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		LRR_RI	93..384	CDD:238064	89/319 (28%)
		leucine-rich repeat	107..129	CDD:275380	6/27 (22%)
		leucine-rich repeat	131..154	CDD:275380	8/23 (35%)
		LRR_8	154..214	CDD:290566	17/60 (28%)
		leucine-rich repeat	155..178	CDD:275380	5/23 (22%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	226..286	CDD:290566	19/59 (32%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	9/22 (41%)
		LRR_8	276..335	CDD:290566	22/79 (28%)
		leucine-rich repeat	276..300	CDD:275380	9/33 (27%)
		leucine-rich repeat	301..324	CDD:275380	7/33 (21%)
		leucine-rich repeat	325..349	CDD:275380	10/23 (43%)
		LRR_8	349..409	CDD:290566	17/59 (29%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
zgc:153913	NP_001073448.1	leucine-rich repeat	75..98	CDD:275380	11/30 (37%)
		LRR_RI	141..>350	CDD:238064	62/210 (30%)
		LRR_8	147..206	CDD:290566	16/58 (28%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		LRR_8	194..252	CDD:290566	17/57 (30%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		leucine-rich repeat	220..241	CDD:275380	7/20 (35%)
		leucine-rich repeat	242..265	CDD:275380	4/22 (18%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		LRR_8	267..324	CDD:290566	21/57 (37%)
		leucine-rich repeat	290..313	CDD:275380	10/23 (43%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..359	CDD:275380	9/21 (43%)
		TPKR_C2	370..>404	CDD:301599	8/36 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000