DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and lrfn2b

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_009292765.1	Gene:	lrfn2b / 558484	ZFINID:	ZDB-GENE-121214-111	Length:	781	Species:	Danio rerio

Alignment Length:	482	Identity:	99/482 - (20%)
Similarity:	154/482 - (31%)	Gaps:	196/482 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPII 83
            |.|:|    |||......:.||:.     |.|                .::::|:|||
Zfish     5 LCQML----VLGMVAVMARACPKY-----CAC----------------QNLSESLGTL------- 37

  Fly    84 FYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQA 148
                     .| .:|.:|:..||...|:.
Zfish    38 ---------CP-AKGLLFVPSDIDRSTVE------------------------------------ 56

  Fly   149 LQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGND 213
                     |.|..|.|..|....|..:..|..|||..|.|:.|.|.:|..||
Zfish    57 ---------LRLGGNFILRITQQDFANMTDLVDLTLSRNTISYIQPFSFGDLE------------ 100

  Fly   214 LTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNS 278
                         ||:.|.:..|::..:...|..||.||..||
Zfish   101 -------------TLRSLHMDNNRLTELGPDDLRGLISLQHLI---------------------- 130

  Fly   279 LELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAF 343
              |..|::|.:.:.||:.|...|:.|.|..|.:..:|..::|.:..|..|.|.:|.::.:.|.
Zfish   131 --LNNNQLSRVSERAFEDLAATLEDLDLSYNNLQALPWHSVRQMINLHQLSLDHNLLDYIPEG-- 191

  Fly   344 TGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQD----------IMEPVIDT 398
                   ||::|::                |..|:|.:|:||::|.|          :|......
Zfish   192 -------TFVDLER----------------LARLDLTSNRLQKLPPDPIFARAQDSEVMTTPFAP 233

  Fly   399 LRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKP----------------LCHMSL--- 444
            ...:.|..|||:|:|||.||.:|     .:||::.....|                ||...|
Zfish   234 QLSLSIGGNPLHCNCELLWFRRL-----ERDDDLETCASPPGLKGRYFWNVREHEFLCEQPLITQ 293

  Fly   445 DNREYFVQAMPTEKMHCAGLNVSPSPT 471
            ...:.......|..:.|..:. .|.||
Zfish   294 HTHKLLALEGQTASLRCDAIG-DPIPT 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	3/19 (16%)
		LRR_RI	93..384	CDD:238064	58/290 (20%)
		leucine-rich repeat	107..129	CDD:275380	1/21 (5%)
		leucine-rich repeat	131..154	CDD:275380	0/22 (0%)
		LRR_8	154..214	CDD:290566	17/59 (29%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..203	CDD:275380	11/23 (48%)
		leucine-rich repeat	204..227	CDD:275380	0/22 (0%)
		LRR_8	226..286	CDD:290566	13/59 (22%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	3/22 (14%)
		LRR_8	276..335	CDD:290566	16/58 (28%)
		leucine-rich repeat	276..300	CDD:275380	6/23 (26%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	5/23 (22%)
		LRR_8	349..409	CDD:290566	14/69 (20%)
		leucine-rich repeat	350..373	CDD:275380	3/22 (14%)
lrfn2b	XP_009292765.1	LRR_RI	27..>209	CDD:238064	63/333 (19%)
		LRR_8	52..112	CDD:290566	22/129 (17%)
		leucine-rich repeat	54..77	CDD:275380	7/67 (10%)
		leucine-rich repeat	78..101	CDD:275380	11/47 (23%)
		LRR_8	101..161	CDD:290566	21/83 (25%)
		LRR_4	102..141	CDD:289563	13/62 (21%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		leucine-rich repeat	126..149	CDD:275380	9/46 (20%)
		LRR_8	150..209	CDD:290566	18/83 (22%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		leucine-rich repeat	175..198	CDD:275380	8/31 (26%)
		leucine-rich repeat	235..246	CDD:275378	4/10 (40%)
		LRRCT	242..>274	CDD:214507	13/36 (36%)
		I-set	289..376	CDD:254352	6/32 (19%)
		Ig	303..376	CDD:299845	5/18 (28%)
		fn3	418..485	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000