DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and slit1a

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001030140.1	Gene:	slit1a / 556123	ZFINID:	ZDB-GENE-030722-3	Length:	1524	Species:	Danio rerio

Alignment Length:	551	Identity:	118/551 - (21%)
Similarity:	194/551 - (35%)	Gaps:	191/551 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QSGCTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITK 71
            :.||.::...|   .||::....|.|      ||     |.|.|    :|..:.|....|.:|.:
Zfish     4 RGGCCLLEVCV---WVLLLVCKTGSG------CP-----ALCTC----SGTTVDCHGLGLKNIPR 50

  Fly    72 SMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDV 136
                                |:|:         :...|.::.::|..|..|..:.|.
Zfish    51 --------------------NIPR---------NTERLELNGNNLTRINRNDFTGLK-------- 78

  Fly   137 SLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLE 201
                             :|.:|.|..|:|..:...||:.:..||.|.|..|::.|: ||......
Zfish    79 -----------------YLRVLQLMENQIVTVERGAFDEMRELERLRLNRNQLHQL-PELLFQKN 125

  Fly   202 DHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVP 266
            ..:.||:|..|.:..||:||....:.:|.|::.:|.|..|.:|.|..::.|:.|.|.:|.|:::|
Zfish   126 AALSRLDLSENFIQAIPRKAFRGATDIKNLQLDKNHISCIEDGAFRAMRGLEVLTLNNNNISSIP 190

  Fly   267 ANVFSHLTLLNSLELEGN------------------------------------KISVIDKDAF- 294
            .:.|:|:..|.:..|..|                                    .::.:.|..|
Zfish   191 VSSFNHMPKLRTFRLHSNNLVCDCVLSWLSQWLRERPNIGLFTQCSSPAPLRGLNVAEVQKHEFS 255

  Fly   295 -----------------------------------KG-------LEENLQYLRLGDNQIHTIPSE 317
                                               ||       |.:::..:||..|.|.:||..
Zfish   256 CSGQSDSAVGQSCSLSSGSCPAVCSCNNNIVDCRGKGPTLIPSSLPDSMTEIRLEQNSIKSIPPG 320

  Fly   318 ALRPLHRLRHLDLRNNNINVLAEDAFTG---------FGDSLT--------------FLNLQKND 359
            |..|..:||.:||.||.|:.||.|||.|         :|:.:|              .|.|..|.
Zfish   321 AFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITDLPRGVFDGLHALQLLLLNANK 385

  Fly   360 IKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLED 424
            |..|.:..|::|.:|..|:|.:||:|.:.:..... :..::.:.:..||..|.|.|.|....|..
Zfish   386 IHCLRANTFQDLQNLSLLSLYDNKIQTLAKGTFSS-LRAIQTLHLAQNPFICDCNLKWLADYLRS 449

  Fly   425 ---------------LKNKDDEMSQKKKPLC 440
                           |.||.....:.||..|
Zfish   450 NPIETSGARCTSPRRLANKRIGQIKSKKFRC 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	2/19 (11%)
		LRR_RI	93..384	CDD:238064	86/392 (22%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		leucine-rich repeat	131..154	CDD:275380	0/22 (0%)
		LRR_8	154..214	CDD:290566	19/59 (32%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	18/95 (19%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	276..335	CDD:290566	22/137 (16%)
		leucine-rich repeat	276..300	CDD:275380	8/102 (8%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	14/32 (44%)
		LRR_8	349..409	CDD:290566	15/73 (21%)
		leucine-rich repeat	350..373	CDD:275380	8/36 (22%)
slit1a	NP_001030140.1	LRRNT	26..57	CDD:214470	12/74 (16%)
		leucine-rich repeat	36..55	CDD:275380	5/47 (11%)
		LRR_8	54..114	CDD:290566	17/93 (18%)
		leucine-rich repeat	56..79	CDD:275380	5/47 (11%)
		leucine-rich repeat	80..103	CDD:275380	7/22 (32%)
		LRR_8	102..162	CDD:290566	19/60 (32%)
		LRR_RI	<104..227	CDD:238064	34/123 (28%)
		leucine-rich repeat	104..127	CDD:275380	8/23 (35%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		LRR_8	153..210	CDD:290566	18/56 (32%)
		leucine-rich repeat	176..199	CDD:275380	8/22 (36%)
		leucine-rich repeat	200..327	CDD:275380	16/126 (13%)
		TPKR_C2	208..257	CDD:301599	3/48 (6%)
		LRRNT	275..306	CDD:214470	3/30 (10%)
		LRR_8	303..362	CDD:290566	22/58 (38%)
		LRR_4	326..366	CDD:289563	15/39 (38%)
		leucine-rich repeat	328..351	CDD:275380	13/22 (59%)
		LRR_8	350..434	CDD:290566	16/84 (19%)
		leucine-rich repeat	352..372	CDD:275380	2/19 (11%)
		LRR_RI	<394..620	CDD:238064	21/88 (24%)
		leucine-rich repeat	400..423	CDD:275380	6/23 (26%)
		leucine-rich repeat	424..521	CDD:275380	13/57 (23%)
		leucine-rich repeat	522..559	CDD:275380
		LRR_8	558..618	CDD:290566
		leucine-rich repeat	560..583	CDD:275380
		leucine-rich repeat	584..607	CDD:275380
		LRR_8	607..666	CDD:290566
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..653	CDD:275380
		leucine-rich repeat	656..747	CDD:275380
		LRRCT	664..712	CDD:214507
		leucine-rich repeat	748..778	CDD:275380
		LRR_8	754..813	CDD:290566
		LRR_4	755..794	CDD:289563
		LRR_4	777..820	CDD:289563
		leucine-rich repeat	779..802	CDD:275380
		leucine-rich repeat	803..823	CDD:275380
		leucine-rich repeat	827..850	CDD:275380
		LRRCT	859..908	CDD:214507
		EGF_CA	920..955	CDD:238011
		EGF_CA	958..996	CDD:238011
		EGF_CA	998..1034	CDD:238011
		EGF_CA	1078..1112	CDD:238011
		LamG	1179..1312	CDD:214598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910