DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and LRRN3

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001093128.1	Gene:	LRRN3 / 54674	HGNCID:	17200	Length:	708	Species:	Homo sapiens

Alignment Length:	413	Identity:	103/413 - (24%)
Similarity:	167/413 - (40%)	Gaps:	98/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAF 173
            |.:..:::|.||.:  :.....||.||:|.|.:.:|.:..::.:..||.:.|..||:|.:.....
Human    74 LLLQTNNIAKIEYS--TDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCL 136

  Fly   174 EGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKI 238
            ..|..|:.|.:..|.::.|.|.||.||. ::.||:|..|.|..|..|....|..|:.|.|.||.|
Human   137 SELSNLQELYINHNLLSTISPGAFIGLH-NLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPI 200

  Fly   239 RTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQY 303
            ..|.:.:|:.|.:|.||::|...:|.:|.|                        |..|| |||:.
Human   201 IRIKDMNFKPLINLRSLVIAGINLTEIPDN------------------------ALVGL-ENLES 240

  Fly   304 LRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLL- 367
            :...||::..:|..||:.:..|:.|||..|.||.:..      ||....|:|::..|..:|.|:
Human   241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRR------GDFSNMLHLKELGINNMPELIS 299

  Fly   368 ------------------------------FENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRII 402
                                          |..|..||:|.|.:|.|..:....:|. :..|:.|
Human   300 IDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIES-LPNLKEI 363

  Fly   403 DITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPTEKMHCAGLNVS 467
            .|..||:.|.|.:.|.                      :|:..|    ::.|..:.:.|    |.
Human   364 SIHSNPIRCDCVIRWM----------------------NMNKTN----IRFMEPDSLFC----VD 398

  Fly   468 PSPTSGGLMRILQVNILAQIAVC 490
            |....|  ..:.||:....:.:|
Human   399 PPEFQG--QNVRQVHFRDMMEIC 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380
		LRR_RI	93..384	CDD:238064	83/305 (27%)
		leucine-rich repeat	107..129	CDD:275380	4/19 (21%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_8	154..214	CDD:290566	20/59 (34%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	16/59 (27%)
		leucine-rich repeat	228..251	CDD:275380	9/22 (41%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	16/58 (28%)
		leucine-rich repeat	276..300	CDD:275380	3/23 (13%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	8/23 (35%)
		LRR_8	349..409	CDD:290566	18/90 (20%)
		leucine-rich repeat	350..373	CDD:275380	7/53 (13%)
LRRN3	NP_001093128.1	LRRNT	28..72	CDD:214470
		LRR 1	70..91		4/18 (22%)
		leucine-rich repeat	72..93	CDD:275380	4/20 (20%)
		LRR	<75..355	CDD:227223	83/313 (27%)
		LRR 2	93..114		7/20 (35%)
		leucine-rich repeat	94..117	CDD:275380	7/22 (32%)
		LRR 3	117..138		6/20 (30%)
		leucine-rich repeat	118..141	CDD:275380	7/22 (32%)
		LRR 4	141..162		7/20 (35%)
		leucine-rich repeat	142..165	CDD:275380	9/23 (39%)
		LRR 5	165..186		7/20 (35%)
		leucine-rich repeat	166..189	CDD:275380	8/22 (36%)
		LRR 6	189..210		8/20 (40%)
		leucine-rich repeat	190..213	CDD:275380	9/22 (41%)
		LRR 7	213..234		8/44 (18%)
		leucine-rich repeat	214..237	CDD:275380	10/47 (21%)
		LRR 8	237..258		7/20 (35%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR 9	261..282		9/26 (35%)
		leucine-rich repeat	262..285	CDD:275380	9/28 (32%)
		LRR 10	285..304		4/18 (22%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR 11	310..332		1/21 (5%)
		leucine-rich repeat	311..333	CDD:275380	1/21 (5%)
		LRR 12	335..358		7/23 (30%)
		leucine-rich repeat	336..359	CDD:275380	7/23 (30%)
		PCC	341..>442	CDD:188093	22/112 (20%)
		Ig	437..513	CDD:325142
		fn3	526..593	CDD:306538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910