DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14762 and Lrrn1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001032440.1	Gene:	Lrrn1 / 500280	RGDID:	1564145	Length:	716	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	122/415 - (29%)
Similarity:	186/415 - (44%)	Gaps:	45/415 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QSGCTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCIC--TVKKNGLDILCETTDLAHI 69
            ::.|.||:.  ||:..|....:|....||..||    ||.|...  :..:....:.|  .|| .:
  Rat     8 KAACWMVLG--LLIPSLTESSILNSECPQLCVC----EIRPWFTPQSTYREATTVDC--NDL-RL 63

  Fly    70 TKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQL 134
            |:..|.|...:.:   |.|:.||:.|....:....::..|....::...|:|..|::| ..||.|
  Rat    64 TRIPGNLSSDTQV---LLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANL-TQLTTL 124

  Fly   135 DVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRG 199
            .:..||:..:....||.|.:|..|.:|||:|:.|..|||.||:.|..|.|..||:..||...|
  Rat   125 HLEENQISEMTDYCLQDLSNLQELYINHNQISSISANAFSGLKNLLRLHLNSNKLKVIDSRWF-- 187

  Fly   200 LEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITT 264
                         |.|          ..|:.|.|.||.:..|.:.:|..|.:|.||:||...:|.
  Rat   188 -------------DST----------PNLEILMIGENPVIGILDMNFRPLSNLRSLVLAGMYLTD 229

  Fly   265 VPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLD 329
            :|.|....|..|.||....||:..:.:.|.:.: .||::|.|..|.||.|.....:.:.||:.|.
  Rat   230 IPGNALVGLDSLESLSFYDNKLIKVPQLALQKV-PNLKFLDLNKNPIHKIQEGDFKNMLRLKELG 293

  Fly   330 LRNNNINVLAEDAFTGFG-DSLTFLNLQKN-DIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIM 392
            : ||...:::.|.:.... ..||.|....| .:..:..|.|.::.:||:|.|.||.|..:.|..:
  Rat   294 I-NNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAVYQKTV 357

  Fly   393 EPVIDTLRIIDITDNPLNCSCELTW 417
            |. :..||.|.|..|||.|.|.:.|
  Rat   358 ES-LPNLREISIHSNPLRCDCVIHW 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	85/292 (29%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	154..214	CDD:290566	20/59 (34%)
		leucine-rich repeat	155..178	CDD:275380	12/22 (55%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	2/22 (9%)
		LRR_8	226..286	CDD:290566	21/59 (36%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	9/22 (41%)
		LRR_8	276..335	CDD:290566	19/58 (33%)
		leucine-rich repeat	276..300	CDD:275380	6/23 (26%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	5/24 (21%)
		LRR_8	349..409	CDD:290566	20/60 (33%)
		leucine-rich repeat	350..373	CDD:275380	6/23 (26%)
Lrrn1	NP_001032440.1	leucine-rich repeat	54..73	CDD:275380	6/21 (29%)
		LRR	<68..372	CDD:227223	98/335 (29%)
		LRR 1	73..95		5/24 (21%)
		leucine-rich repeat	74..96	CDD:275380	5/24 (21%)
		LRR 2	96..117		4/20 (20%)
		leucine-rich repeat	97..120	CDD:275380	5/23 (22%)
		LRR 3	120..141		6/20 (30%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR 4	144..165		10/20 (50%)
		leucine-rich repeat	145..168	CDD:275380	12/22 (55%)
		LRR 5	168..189		8/35 (23%)
		leucine-rich repeat	169..192	CDD:275380	10/47 (21%)
		LRR 6	192..213		7/20 (35%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		LRR 7	216..237		8/20 (40%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		LRR 8	240..261		6/20 (30%)
		leucine-rich repeat	241..264	CDD:275380	6/23 (26%)
		LRR 9	264..285		8/20 (40%)
		leucine-rich repeat	265..288	CDD:275380	7/22 (32%)
		leucine-rich repeat	289..313	CDD:275380	5/24 (21%)
		leucine-rich repeat	314..335	CDD:275380	6/20 (30%)
		leucine-rich repeat	339..362	CDD:275378	9/23 (39%)
		leucine-rich repeat	363..375	CDD:275378	7/11 (64%)
		LRRCT	371..419	CDD:214507	6/11 (55%)
		I-set	429..516	CDD:400151
		Ig strand A'	433..438	CDD:409353
		Ig strand B	441..450	CDD:409353
		Ig strand C	456..460	CDD:409353
		Ig strand C'	463..465	CDD:409353
		Ig strand D	478..481	CDD:409353
		Ig strand E	482..487	CDD:409353
		Ig strand F	495..503	CDD:409353
		Ig strand G	506..516	CDD:409353
		FN3	531..600	CDD:214495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910