DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Tollo

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	126/498 - (25%)
Similarity:	204/498 - (40%)	Gaps:	119/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ILCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENA 123
            ::|....|.|:..|                 :|.:..:..|.|.|                   :
  Fly   171 MVCPLKSLQHLNAS-----------------YNKIQDISNFYFSA-------------------S 199

  Fly   124 LSS-----LGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILT 183
            |||     .|:.|..||:|.|:|.::|:..|..|..|..||:..|.::.:.:.|||||.:|.::.
  Fly   200 LSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVD 264

  Fly   184 LYENKITQIDPEAF---RGLEDHIKR--------------------LNLGGNDLTN--IPQKALS 223
            |..|::|.:.||.|   :.|::...|                    |:|..|:|.:  |......
  Fly   265 LSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFV 329

  Fly   224 ILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISV 288
            .|..|..|::..|||..:....|..|.||..|.|..|.|..:|..:|:.||.|::|.|..|:|||
  Fly   330 GLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISV 394

  Fly   289 IDKDAFKGLE-----------------------ENLQYLRLGDNQIHTIPSEALRPLHRLRHLDL 330
            |::...:||:                       ..||.|.|.||::..:| |||..:..|:.||:
  Fly   395 IEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVP-EALAHVQLLKTLDV 458

  Fly   331 RNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPV 395
            ..|.|:.:...:.|.. :||..|.:.:|.:..:...:|:.::||:.|||..|||:.|....::.
  Fly   459 GENMISQIENTSITQL-ESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQR- 521

  Fly   396 IDTLRIIDITDNPLNCSCEL-TWFPKL--LEDLKNKDDEMSQKKKPLCHMSLDNR--------EY 449
            ...|:.|.:..|.|.....| |..|.|  |....|:.::......|:....||.|        .|
  Fly   522 NSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNY 586

  Fly   450 FVQAMPTEKMHCAGLNVSPSPTSGGLMRILQVNILAQIAVCSV 492
            |  .:.:|      |::|....|        .|:|.:|...|:
  Fly   587 F--EIESE------LSLSTFDAS--------YNLLTEITASSI 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		LRR_RI	93..384	CDD:238064	94/343 (27%)
		leucine-rich repeat	107..129	CDD:275380	3/26 (12%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR_8	154..214	CDD:290566	21/82 (26%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..203	CDD:275380	8/26 (31%)
		leucine-rich repeat	204..227	CDD:275380	7/44 (16%)
		LRR_8	226..286	CDD:290566	21/59 (36%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	276..335	CDD:290566	24/81 (30%)
		leucine-rich repeat	276..300	CDD:275380	10/46 (22%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		LRR_8	349..409	CDD:290566	17/59 (29%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	37/145 (26%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	17/86 (20%)
		leucine-rich repeat	154..177	CDD:275380	1/5 (20%)
		leucine-rich repeat	178..201	CDD:275380	7/58 (12%)
		LRR	210..656	CDD:227223	114/423 (27%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	236..259	CDD:275380	9/22 (41%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR_RI	276..558	CDD:238064	77/284 (27%)
		leucine-rich repeat	284..307	CDD:275380	2/22 (9%)
		leucine-rich repeat	308..333	CDD:275380	6/24 (25%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	10/22 (45%)
		leucine-rich repeat	406..429	CDD:275380	0/22 (0%)
		leucine-rich repeat	430..452	CDD:275380	10/22 (45%)
		leucine-rich repeat	453..500	CDD:275380	11/47 (23%)
		leucine-rich repeat	501..521	CDD:275380	8/19 (42%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	4/24 (17%)
		leucine-rich repeat	604..640	CDD:275380	3/10 (30%)
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010