DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and 2mit

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	111/375 - (29%)
Similarity:	173/375 - (46%)	Gaps:	43/375 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALD----IRHLTIHNSSLAAIEEN-AL 124
            ||.....:.|..||...:|..:.|..|.|..      |:||    :|.|.:.|:||..|..: |.
  Fly   105 DLRTFNSTGGQWKGDFQVITAMDLSSNQLES------LSLDNFNQLRQLDLGNNSLEVIPLSLAD 163

  Fly   125 SSLGAGLTQLDVSLNQMKTVPSQAL-QHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENK 188
            :::......||:|.|:...:.:... |.|..|..|||.||::..|...:|..|..|:.|.|..|.
  Fly   164 TNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNN 228

  Fly   189 ITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDF------- 246
            |:.||.|.|..| .:::.|:|..|.|:....:||..:..|..|.|..|....::..:|
  Fly   229 ISDIDYETFLAL-PNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLK 292

  Fly   247 ------EGL--------QSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGL 297
                  .||        ||:.:|.|:.|.:..:.........||..|:|..::|:.::.||. |.
  Fly   293 ELDASGTGLCQVPAALAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDAL-GR 356

  Fly   298 EENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKV 362
            .|.|:.|.|..|.:..:|| :|.|  .|.||.|::|.|..|...||.|. .:|..|:|..|.:..
  Fly   357 LELLESLFLDRNLLMRVPS-SLPP--SLEHLFLQHNQIMELPPQAFVGL-VNLQTLDLSNNRLIF 417

  Fly   363 LPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCS 412
            ||.|   :|..|.||||:::.::.:.|.|:. .:..||.:.:.|||:.||
  Fly   418 LPPL---SLPKLLTLNLESSGVESVSQSIVH-TLPQLRDLLLEDNPIKCS 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		LRR_RI	93..384	CDD:238064	94/317 (30%)
		leucine-rich repeat	107..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	131..154	CDD:275380	6/23 (26%)
		LRR_8	154..214	CDD:290566	22/59 (37%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..203	CDD:275380	10/23 (43%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	226..286	CDD:290566	16/80 (20%)
		leucine-rich repeat	228..251	CDD:275380	7/43 (16%)
		leucine-rich repeat	252..275	CDD:275380	3/22 (14%)
		LRR_8	276..335	CDD:290566	21/58 (36%)
		leucine-rich repeat	276..300	CDD:275380	7/23 (30%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	10/23 (43%)
		LRR_8	349..409	CDD:290566	19/59 (32%)
		leucine-rich repeat	350..373	CDD:275380	8/22 (36%)
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	63/238 (26%)
		leucine-rich repeat	124..143	CDD:275380	6/24 (25%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..194	CDD:275380	6/21 (29%)
		LRR_8	193..253	CDD:290566	22/60 (37%)
		leucine-rich repeat	195..218	CDD:275380	9/22 (41%)
		leucine-rich repeat	219..242	CDD:275380	10/23 (43%)
		LRR_8	241..301	CDD:290566	11/59 (19%)
		leucine-rich repeat	243..311	CDD:275380	13/67 (19%)
		leucine-rich repeat	312..335	CDD:275380	3/22 (14%)
		LRR_8	334..415	CDD:290566	31/85 (36%)
		leucine-rich repeat	336..359	CDD:275380	7/23 (30%)
		leucine-rich repeat	360..380	CDD:275380	8/22 (36%)
		LRR_8	379..460	CDD:290566	30/87 (34%)
		LRR_4	379..>415	CDD:289563	15/38 (39%)
		leucine-rich repeat	381..404	CDD:275380	10/23 (43%)
		leucine-rich repeat	405..449	CDD:275380	15/47 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010