DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and CG7800

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	107/421 - (25%)
Similarity:	173/421 - (41%)	Gaps:	94/421 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLT-IHNSSLAAIEENAL 124
            |::.|.     :|..| .:.|.:..|:||..||        |.|...|.: ..|..:..:..|.:
  Fly    73 CDSPDF-----TMNDL-NQLPYLTSLQLRRGNL--------LGLHDEHFSKWPNMKILMLGGNNI 123

  Fly   125 SSLG----AGLTQ---LDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEIL 182
            :.|.    .||.|   |.:..|.::.:|....|:|..||.|:|:.|:|..:|.|.|.|:..||:|
  Fly   124 TRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHENIFTGVPKLEML 188

  Fly   183 TLYENKITQIDPEAFRGLED----------HIKRLNLGGND---LTNIPQKALSILSTLKKLEIQ 234
            .|..|.:|.|.|.:.:.|.:          .:..|:|.|..   |.|...:.|.||.::.||:.:
  Fly   189 LLNGNPLTWIAPTSLKSLSNLRLLDMSNCGPLPDLSLPGAHTLILDNSGVQRLDILGSVHKLQAR 253

  Fly   235 ENKIRTISEGDFEGLQSLDSLILAHNMITT--VPANVFSHLTLLNSLELEGNKISVI-----DKD 292
            :|.|..|...|...:..||   |..|::|.  :| .:.:.:..|..|:|..|.|.:.     |..
  Fly   254 KNHITEIKLPDKSSVIELD---LHSNLLTATDIP-KLLTGMWRLQRLDLSENIIGIYAAAGSDNT 314

  Fly   293 AFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNI----NVLAEDAFTGFGDSLTFL 353
            :...:..||.|:.|..|::..:..::..|..||.|||...|.|    .|..::||     :|..|
  Fly   315 SELFILPNLMYMNLSANRLTRLHFDSPIPWERLTHLDASYNRIYAPAKVGIDEAF-----NLQSL 374

  Fly   354 NLQKNDIKVLPSLLFENLNSLETLNLQNNKLQ------------RIPQDIME------------- 393
            :|:.|.|.......::...||:.:.|.:||.|            .|..:::|
  Fly   375 HLEGNYINNFELTPWKPHPSLKEVALYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPT 439

  Fly   394 --PVI------------DTLRIIDITDNPLN 410
              |.|            ||.:.||...|||:
  Fly   440 CKPCIPDARDFPTSISADTNQTIDTKVNPLS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	6/19 (32%)
		LRR_RI	93..384	CDD:238064	85/322 (26%)
		leucine-rich repeat	107..129	CDD:275380	4/26 (15%)
		leucine-rich repeat	131..154	CDD:275380	7/25 (28%)
		LRR_8	154..214	CDD:290566	22/72 (31%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	9/33 (27%)
		leucine-rich repeat	204..227	CDD:275380	8/25 (32%)
		LRR_8	226..286	CDD:290566	16/61 (26%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	6/24 (25%)
		LRR_8	276..335	CDD:290566	18/63 (29%)
		leucine-rich repeat	276..300	CDD:275380	6/28 (21%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..349	CDD:275380	9/27 (33%)
		LRR_8	349..409	CDD:290566	20/98 (20%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380
		leucine-rich repeat	65..85	CDD:275380	4/17 (24%)
		LRR_8	87..147	CDD:290566	17/67 (25%)
		leucine-rich repeat	89..112	CDD:275380	8/30 (27%)
		leucine-rich repeat	113..136	CDD:275380	4/22 (18%)
		LRR_RI	<131..334	CDD:238064	58/206 (28%)
		leucine-rich repeat	137..160	CDD:275380	5/22 (23%)
		LRR_8	140..195	CDD:290566	20/54 (37%)
		leucine-rich repeat	161..184	CDD:275380	10/22 (45%)
		leucine-rich repeat	185..208	CDD:275380	9/22 (41%)
		leucine-rich repeat	209..246	CDD:275380	8/36 (22%)
		leucine-rich repeat	247..267	CDD:275380	6/19 (32%)
		leucine-rich repeat	268..292	CDD:275380	6/27 (22%)
		leucine-rich repeat	293..322	CDD:275380	6/28 (21%)
		leucine-rich repeat	395..406	CDD:275378	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100